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4304. Prevalence of Diabetes and Cardiovascular Risk in the Middle East and Africa: Primary Results of the PACT-MEA Study.
作者: Subodh Verma.;Naji Alamuddin.;Fatheya Alawadi.;Hessa Alkandari.;Wael Almahmeed.;Samir H Assaad-Khalil.;Jihad Haddad.;Lise Lotte N Husemoen.;Landman Lombard.;Rayaz A Malik.;Emel Mashaki Ceyhan.;Hani Sabbour.;Gamze Tombak.;Gourav Yadav.;Sam Salek.
来源: Circulation. 2023年147卷16期1251-1255页 4305. Pulsed Field Ablation for the Treatment of Atrial Fibrillation: PULSED AF Pivotal Trial.
作者: Atul Verma.;David E Haines.;Lucas V Boersma.;Nitesh Sood.;Andrea Natale.;Francis E Marchlinski.;Hugh Calkins.;Prashanthan Sanders.;Douglas L Packer.;Karl-Heinz Kuck.;Gerhard Hindricks.;Birce Onal.;Jeffrey Cerkvenik.;Hiroshi Tada.;David B DeLurgio.; .
来源: Circulation. 2023年147卷19期1422-1432页
Pulsed field ablation uses electrical pulses to cause nonthermal irreversible electroporation and induce cardiac cell death. Pulsed field ablation may have effectiveness comparable to traditional catheter ablation while preventing thermally mediated complications.
4307. Application of 3-Dimensional Fetal Echocardiography in the Detection of Hidden Extended Ventricular Septal Defect.
作者: Gioia Mastromoro.;Valerio Romano.;Riccardo Riccardi.;Luigi Orfeo.;Gerardo Piacentini.
来源: Circ Cardiovasc Imaging. 2023年16卷7期594-596页 4308. Disruption of Phosphodiesterase 3A Binding to SERCA2 Increases SERCA2 Activity and Reduces Mortality in Mice With Chronic Heart Failure.
作者: Jonas Skogestad.;Ingrid Albert.;Karina Hougen.;Gustav B Lothe.;Marianne Lunde.;Olav Søvik Eken.;Ioanni Veras.;Ngoc Trang Thi Huynh.;Mira Børstad.;Serena Marshall.;Xin Shen.;William E Louch.;Emma Louise Robinson.;Joseph C Cleveland.;Amrut V Ambardekar.;Jessica A Schwisow.;Eric Jonas.;Ana I Calejo.;Jens Preben Morth.;Kjetil Taskén.;Arne Olav Melleby.;Per Kristian Lunde.;Ivar Sjaastad.;Cathrine Rein Carlson.;Jan Magnus Aronsen.
来源: Circulation. 2023年147卷16期1221-1236页
Increasing SERCA2 (sarco[endo]-plasmic reticulum Ca2+ ATPase 2) activity is suggested to be beneficial in chronic heart failure, but no selective SERCA2-activating drugs are available. PDE3A (phosphodiesterase 3A) is proposed to be present in the SERCA2 interactome and limit SERCA2 activity. Disruption of PDE3A from SERCA2 might thus be a strategy to develop SERCA2 activators.
4309. Patient Characteristics, Outcomes, and Effects of Dapagliflozin According to the Duration of Heart Failure: A Prespecified Analysis of the DELIVER Trial.
作者: Toru Kondo.;Karola S Jering.;C Jan Willem Borleffs.;Rudolf A de Boer.;Brian L Claggett.;Akshay S Desai.;Dan Dobreanu.;Silvio E Inzucchi.;Adrian F Hernandez.;Stefan P Janssens.;Pardeep S Jhund.;Mikhail N Kosiborod.;Carolyn S P Lam.;Anna Maria Langkilde.;Felipe A Martinez.;Magnus Petersson.;Pham Nguyen Vinh.;Muthiah Vaduganathan.;Scott D Solomon.;John J V McMurray.
来源: Circulation. 2023年147卷14期1067-1078页
How patient characteristics and outcomes vary according to the duration of heart failure (HF) is unknown in individuals with mildly reduced or preserved ejection fraction. We compared these, and the efficacy and safety of dapagliflozin, according to the time from diagnosis of HF in a prespecified analysis of the DELIVER trial (Dapagliflozin Evaluation to Improve the Lives of Patients With Preserved Ejection Fraction Heart Failure).
4310. Exposure to Arterial Hyperoxia During Extracorporeal Membrane Oxygenator Support and Mortality in Patients With Cardiogenic Shock.
作者: Jacob C Jentzer.;P Elliott Miller.;Carlos Alviar.;Suraj Yalamuri.;J Kyle Bohman.;Joseph E Tonna.
来源: Circ Heart Fail. 2023年16卷4期e010328页
Exposure to hyperoxia, a high arterial partial pressure of oxygen (PaO2), may be associated with worse outcomes in patients receiving extracorporeal membrane oxygenator (ECMO) support. We examined hyperoxia in the Extracorporeal Life Support Organization Registry among patients receiving venoarterial ECMO for cardiogenic shock.
4311. Comparison of 3- to 6-Month Versus 12-Month Dual Antiplatelet Therapy After Coronary Intervention Using the Contemporary Drug-Eluting Stents With Ultrathin Struts: The HOST-IDEA Randomized Clinical Trial.
作者: Jung-Kyu Han.;Doyeon Hwang.;Seokhun Yang.;Sang-Hyeon Park.;Jeehoon Kang.;Han-Mo Yang.;Kyung Woo Park.;Hyun-Jae Kang.;Bon-Kwon Koo.;Seung-Ho Hur.;Weon Kim.;Seok Yeon Kim.;Sang-Hyun Park.;Seung Hwan Han.;Sang-Hyun Kim.;Sanghoon Shin.;Yong Hoon Kim.;Kyungil Park.;Namho Lee.;Seung Jin Lee.;Jin Won Kim.;Hyo-Soo Kim.
来源: Circulation. 2023年147卷18期1358-1368页
Limited data are available on short-term dual antiplatelet therapy (DAPT) after percutaneous coronary intervention using third-generation drug-eluting stents with ultrathin struts and advanced polymer technology. We investigated whether 3- to 6-month DAPT was noninferior to 12-month DAPT after implantation of drug-eluting stents with ultrathin struts and advanced polymer technology.
4312. Eliminating Medication Copayments for Low-Income Older Adults at High Cardiovascular Risk: A Randomized Controlled Trial.
作者: David J T Campbell.;Chad Mitchell.;Brenda R Hemmelgarn.;Marcello Tonelli.;Peter Faris.;Jianguo Zhang.;Ross T Tsuyuki.;Jane Fletcher.;Flora Au.;Scott Klarenbach.;Derek V Exner.;Braden J Manns.; .
来源: Circulation. 2023年147卷20期1505-1514页
One in eight people with heart disease has poor medication adherence that, in part, is related to copayment costs. This study tested whether eliminating copayments for high-value medications among low-income older adults at high cardiovascular risk would improve clinical outcomes.
4313. Cluster Randomized Trial of a Personalized Clinical Decision Support Intervention to Improve Statin Prescribing in Patients With Atherosclerotic Cardiovascular Disease.
作者: Salim S Virani.;David J Ramsey.;Dax Westerman.;Mark K Kuebeler.;Liang Chen.;Julia M Akeroyd.;Glenn T Gobbel.;Christie M Ballantyne.;Laura A Petersen.;Alexander Turchin.;Michael E Matheny.
来源: Circulation. 2023年147卷18期1411-1413页 4314. Effect of Electronic Nudges on Influenza Vaccination Rate in Older Adults With Cardiovascular Disease: Prespecified Analysis of the NUDGE-FLU Trial.
作者: Daniel Modin.;Niklas Dyrby Johansen.;Muthiah Vaduganathan.;Ankeet S Bhatt.;Simin Gharib Lee.;Brian L Claggett.;Erica L Dueger.;Sandrine I Samson.;Matthew M Loiacono.;Lars Køber.;Scott D Solomon.;Pradeesh Sivapalan.;Jens Ulrik Stæhr Jensen.;Cyril Jean-Marie Martel.;Palle Valentiner-Branth.;Tyra Grove Krause.;Tor Biering-Sørensen.
来源: Circulation. 2023年147卷18期1345-1354页
Influenza vaccines have been demonstrated to effectively reduce the incidence of influenza infection and potentially associated risks of cardiovascular events in patients with cardiovascular disease (CVD). Despite strong guideline and public health endorsements, global influenza vaccination rates in patients with CVD are highly variable. This prespecified analysis of NUDGE-FLU (Nationwide Utilization of Danish Government Electronic Letter System for Increasing Influenza Vaccine Uptake) examined the effect of digital behavioral nudges on influenza vaccine uptake based on the presence of CVD.
4315. Self-Management Support Using Advertising Principles for Older Adults With Low Income at High Cardiovascular Risk: A Randomized Controlled Trial.
作者: David J T Campbell.;Marcello Tonelli.;Brenda R Hemmelgarn.;Peter Faris.;Jianguo Zhang.;Flora Au.;Ross T Tsuyuki.;Chad Mitchell.;Raj Pannu.;Tavis Campbell.;Noah Ivers.;Jane Fletcher.;Derek V Exner.;Braden J Manns.; .
来源: Circulation. 2023年147卷20期1492-1504页
Self-management education and support (SMES) interventions have modest effects on intermediate outcomes for those at risk of cardiovascular disease, but few studies have measured or demonstrated an effect on clinical end points. Advertising for commercial products is known to influence behavior, but advertising principles are not typically incorporated into SMES design.
4317. On-Site Computed Tomography-Derived Fractional Flow Reserve to Guide Management of Patients With Stable Coronary Artery Disease: The TARGET Randomized Trial.
作者: Junjie Yang.;Dongkai Shan.;Xi Wang.;Xiaoqing Sun.;Meihua Shao.;Kan Wang.;Yueying Pan.;Zhiqiang Wang.;U Joseph Schoepf.;Rock H Savage.;Mei Zhang.;Mei Dong.;Lei Xu.;Yujie Zhou.;Xiang Ma.;Xinyang Hu.;Liming Xia.;Hesong Zeng.;Zinuan Liu.;Yundai Chen.
来源: Circulation. 2023年147卷18期1369-1381页
Computed tomography-derived fractional flow reserve (CT-FFR) using on-site machine learning enables identification of both the presence of coronary artery disease and vessel-specific ischemia. However, it is unclear whether on-site CT-FFR improves clinical or economic outcomes when compared with the standard of care in patients with stable coronary artery disease.
4318. Novel Calmodulin Variant p.E46K Associated With Severe Catecholaminergic Polymorphic Ventricular Tachycardia Produces Robust Arrhythmogenicity in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
作者: Jingshan Gao.;Takeru Makiyama.;Yuta Yamamoto.;Takuya Kobayashi.;Hisaaki Aoki.;Thomas L Maurissen.;Yimin Wuriyanghai.;Asami Kashiwa.;Tomohiko Imamura.;Takanori Aizawa.;Hai Huang.;Hirohiko Kohjitani.;Misato Nishikawa.;Kazuhisa Chonabayashi.;Megumi Fukuyama.;Hiromi Manabe.;Kouichi Nakau.;Tsutomu Wada.;Koichi Kato.;Futoshi Toyoda.;Yoshinori Yoshida.;Naomasa Makita.;Knut Woltjen.;Seiko Ohno.;Nagomi Kurebayashi.;Takashi Murayama.;Takashi Sakurai.;Minoru Horie.;Takeshi Kimura.
来源: Circ Arrhythm Electrophysiol. 2023年16卷3期e011387页
CaM (calmodulin) is a ubiquitously expressed, multifunctional Ca2+ sensor protein that regulates numerous proteins. Recently, CaM missense variants have been identified in patients with malignant inherited arrhythmias, such as long QT syndrome and catecholaminergic polymorphic ventricular tachycardia (CPVT). However, the exact mechanism of CaM-related CPVT in human cardiomyocytes remains unclear. In this study, we sought to investigate the arrhythmogenic mechanism of CPVT caused by a novel variant using human induced pluripotent stem cell (iPSC) models and biochemical assays.
4319. Association of Predicted Damaging De Novo Variants on Ventricular Function in Individuals With Congenital Heart Disease.
作者: Matthew J Lewis.;Alexander Hsieh.;Lu Qiao.;Renjie Tan.;Brigitte Kazzi.;Alexandra Channing.;Emily L Griffin.;Vaidehi Jobanputra.;Jennifer Su.;Chowdhury Shahryar.;Lazaros Kochilas.;J William Gaynor.;Teresa Lee.;Elizabeth Goldmuntz.;Mark Russell.;Seema Mital.;Martin Tristani.;Martina Brueckner.;Jane Newburger.;Yufeng Shen.;Wendy K Chung.
来源: Circ Genom Precis Med. 2023年16卷2期e003900页 4320. Modeling of the Tricuspid Valve and Right Ventricle in Hypoplastic Left Heart Syndrome With a Fontan Circulation.
作者: Hannah H Nam.;Maura Flynn.;Andras Lasso.;Christian Herz.;Patricia Sabin.;Yan Wang.;Alana Cianciulli.;Chad Vigil.;Jing Huang.;Jared Vicory.;Beatriz Paniagua.;David Allemang.;David J Goldberg.;Mohammed Nuri.;Meryl S Cohen.;Gabor Fichtinger.;Matthew A Jolley.
来源: Circ Cardiovasc Imaging. 2023年16卷3期e014671页
In hypoplastic left heart syndrome, tricuspid regurgitation (TR) is associated with circulatory failure and death. We hypothesized that the tricuspid valve (TV) structure of patients with hypoplastic left heart syndrome with a Fontan circulation and moderate or greater TR differs from those with mild or less TR, and that right ventricle volume is associated with TV structure and dysfunction.
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