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4081. Genetic Burden of TNNI3K in Diagnostic Testing of Patients With Dilated Cardiomyopathy and Supraventricular Arrhythmias.
作者: Caroline Pham.;Karolina Andrzejczyk.;Sean J Jurgens.;Ronald Lekanne Deprez.;Kaylin C A Palm.;Alexa M C Vermeer.;Janneke Nijman.;Imke Christiaans.;Daniela Q C M Barge-Schaapveld.;Pascal F H M van Dessel.;Leander Beekman.;Seung Hoan Choi.;Steven A Lubitz.;Doris Skoric-Milosavljevic.;Lisa van den Bersselaar.;Philip R Jansen.;Jaël S Copier.;Patrick T Ellinor.;Arthur A M Wilde.;Connie R Bezzina.;Elisabeth M Lodder.
来源: Circ Genom Precis Med. 2023年16卷4期328-336页
Genetic variants in TNNI3K (troponin-I interacting kinase) have previously been associated with dilated cardiomyopathy (DCM), cardiac conduction disease, and supraventricular tachycardias. However, the link between TNNI3K variants and these cardiac phenotypes shows a lack of consensus concerning phenotype and protein function.
4082. Safety and Effectiveness of Pulsed Field Ablation to Treat Atrial Fibrillation: One-Year Outcomes From the MANIFEST-PF Registry.
作者: Mohit K Turagam.;Petr Neuzil.;Boris Schmidt.;Tobias Reichlin.;Kars Neven.;Andreas Metzner.;Jim Hansen.;Yuri Blaauw.;Philippe Maury.;Thomas Arentz.;Philipp Sommer.;Ante Anic.;Frédéric Anselme.;Serge Boveda.;Tom Deneke.;Stephan Willems.;Pepijn van der Voort.;Roland Tilz.;Moritoshi Funasako.;Daniel Scherr.;Reza Wakili.;Daniel Steven.;Josef Kautzner.;Johan Vijgen.;Pierre Jais.;Jan Petru.;Julian Chun.;Laurent Roten.;Anna Füting.;Marc D Lemoine.;Martin Ruwald.;Bart A Mulder.;Anne Rollin.;Heiko Lehrmann.;Thomas Fink.;Zrinka Jurisic.;Corentin Chaumont.;Raquel Adeliño.;Karin Nentwich.;Melanie Gunawardene.;Alexandre Ouss.;Christian-Hendrik Heeger.;Martin Manninger.;Jan-Eric Bohnen.;Arian Sultan.;Petr Peichl.;Pieter Koopman.;Nicolas Derval.;Thomas Kueffer.;Gilbert Rahe.;Vivek Y Reddy.
来源: Circulation. 2023年148卷1期35-46页
Pulsed field ablation is a novel nonthermal cardiac ablation modality using ultra-rapid electrical pulses to cause cell death by a mechanism of irreversible electroporation. Unlike the traditional ablation energy sources, pulsed field ablation has demonstrated significant preferentiality to myocardial tissue ablation, and thus avoids certain thermally mediated complications. However, its safety and effectiveness remain unknown in usual clinical care.
4083. INKILN is a Novel Long Noncoding RNA Promoting Vascular Smooth Muscle Inflammation via Scaffolding MKL1 and USP10.
作者: Wei Zhang.;Jinjing Zhao.;Lin Deng.;Nestor Ishimwe.;Jessica Pauli.;Wen Wu.;Shengshuai Shan.;Wolfgang Kempf.;Margaret D Ballantyne.;David Kim.;Qing Lyu.;Matthew Bennett.;Julie Rodor.;Adam W Turner.;Yao Wei Lu.;Ping Gao.;Mihyun Choi.;Ganesh Warthi.;Ha Won Kim.;Margarida M Barroso.;William B Bryant.;Clint L Miller.;Neal L Weintraub.;Lars Maegdefessel.;Joseph M Miano.;Andrew H Baker.;Xiaochun Long.
来源: Circulation. 2023年148卷1期47-67页
Activation of vascular smooth muscle cell (VSMC) inflammation is vital to initiate vascular disease. The role of human-specific long noncoding RNAs in VSMC inflammation is poorly understood.
4084. Retained Metabolic Flexibility of the Failing Human Heart.
作者: William D Watson.;Peregrine G Green.;Andrew J M Lewis.;Per Arvidsson.;Giovanni Luigi De Maria.;Håkan Arheden.;Einar Heiberg.;William T Clarke.;Christopher T Rodgers.;Ladislav Valkovič.;Stefan Neubauer.;Neil Herring.;Oliver J Rider.
来源: Circulation. 2023年148卷2期109-123页
The failing heart is traditionally described as metabolically inflexible and oxygen starved, causing energetic deficit and contractile dysfunction. Current metabolic modulator therapies aim to increase glucose oxidation to increase oxygen efficiency of adenosine triphosphate production, with mixed results.
4085. Shorter Door-to-Needle Times Are Associated With Better Outcomes After Intravenous Thrombolytic Therapy and Endovascular Thrombectomy for Acute Ischemic Stroke.
作者: Shumei Man.;Nicole Solomon.;Brian Mac Grory.;Brooke Alhanti.;Ken Uchino.;Jeffrey L Saver.;Eric E Smith.;Ying Xian.;Deepak L Bhatt.;Lee H Schwamm.;Muhammad Shazam Hussain.;Gregg C Fonarow.
来源: Circulation. 2023年148卷1期20-34页
Existing data and clinical trials could not determine whether faster intravenous thrombolytic therapy (IVT) translates into better long-term functional outcomes after acute ischemic stroke among those treated with endovascular thrombectomy (EVT). Patient-level national data can provide the required large population to study the associations between earlier IVT, versus later, with longitudinal functional outcomes and mortality in patients receiving IVT+EVT combined treatment.
4086. Rare Genetic Variants Associated With Sudden Cardiac Arrest in the Young: A Prospective, Population-Based Study.
作者: Lauri Holmstrom.;Ninad S Chaudhary.;Kotoka Nakamura.;Harpriya Chugh.;Audrey Uy-Evanado.;Faye Norby.;Ginger A Metcalf.;Vipin K Menon.;Bing Yu.;Eric Boerwinkle.;Sumeet S Chugh.;Zeynep Akdemir.;Evan P Kransdorf.
来源: Circ Genom Precis Med. 2023年16卷4期404-405页 4087. Right Ventricular Sarcomere Contractile Depression and the Role of Thick Filament Activation in Human Heart Failure With Pulmonary Hypertension.
作者: Vivek Jani.;M Imran Aslam.;Axel J Fenwick.;Weikang Ma.;Henry Gong.;Gregory Milburn.;Devin Nissen.;Ilton M Cubero Salazar.;Olivia Hanselman.;Monica Mukherjee.;Marc K Halushka.;Kenneth B Margulies.;Kenneth S Campbell.;Thomas C Irving.;David A Kass.;Steven Hsu.
来源: Circulation. 2023年147卷25期1919-1932页
Right ventricular (RV) contractile dysfunction commonly occurs and worsens outcomes in patients with heart failure with reduced ejection fraction and pulmonary hypertension (HFrEF-PH). However, such dysfunction often goes undetected by standard clinical RV indices, raising concerns that they may not reflect aspects of underlying myocyte dysfunction. We thus sought to characterize RV myocyte contractile depression in HFrEF-PH, identify those components reflected by clinical RV indices, and uncover underlying biophysical mechanisms.
4088. Prevalence of Pathogenic Variants in Dilated Cardiomyopathy-Associated Genes in Patients Evaluated for Cardiac Sarcoidosis.
作者: Nosheen Reza.;Michael G Levin.;Mahesh K Vidula.;Paco E Bravo.;Scott M Damrauer.;Marylyn D Ritchie.; .;C Anwar A Chahal.;Anjali Tiku Owens.
来源: Circ Genom Precis Med. 2023年16卷4期409-411页 4089. Combined Clinical, Molecular, and Muscle Biopsy Approach to Unveil Prevalence and Clinical Features of Rare Neuromuscular and Mitochondrial Diseases in Patients With Cardiomyopathies.
作者: Michele Lioncino.;Emanuele Monda.;Martina Caiazza.;Vincenzo Simonelli.;Claudia Nesti.;Alfredo Mauriello.;Alberta Budillon.;Alessandro Di Santo.;Giorgia Bruno.;Antonio Varone.;Vincenzo Nigro.;Filippo Maria Santorelli.;Giuseppe Pacileo.;Maria Giovanna Russo.;Giulia Frisso.;Simone Sampaolo.;Giuseppe Limongelli.
来源: Circ Genom Precis Med. 2023年16卷4期412-414页 4090. KIDS SAVE LIVES: Basic Life Support Education for Schoolchildren: A Narrative Review and Scientific Statement From the International Liaison Committee on Resuscitation.
作者: Daniel C Schroeder.;Federico Semeraro.;Robert Greif.;Janet Bray.;Peter Morley.;Michael Parr.;Naomi Kondo Nakagawa.;Taku Iwami.;Simon-Richard Finke.;Carolina Malta Hansen.;Andrew Lockey.;Marina Del Rios.;Farhan Bhanji.;Comilla Sasson.;Stephen M Schexnayder.;Tommaso Scquizzato.;Wolfgang A Wetsch.;Bernd W Böttiger.; .
来源: Circulation. 2023年147卷24期1854-1868页
Basic life support education for schoolchildren has become a key initiative to increase bystander cardiopulmonary resuscitation rates. Our objective was to review the existing literature on teaching schoolchildren basic life support to identify the best practices to provide basic life support training in schoolchildren.
4092. Transcatheter Mitral Valve Replacement Versus Medical Therapy for Secondary Mitral Regurgitation: A Propensity Score-Matched Comparison.
作者: Sebastian Ludwig.;Lenard Conradi.;David J Cohen.;Augustin Coisne.;Andrea Scotti.;William T Abraham.;Walid Ben Ali.;Zhipeng Zhou.;Yanru Li.;Saibal Kar.;Alison Duncan.;D Scott Lim.;Marianna Adamo.;Björn Redfors.;David W M Muller.;John G Webb.;Anna S Petronio.;Hendrik Ruge.;Georg Nickenig.;Lars Sondergaard.;Matti Adam.;Damiano Regazzoli.;Andrea Garatti.;Tobias Schmidt.;Martin Andreas.;Gry Dahle.;Thomas Walther.;Joerg Kempfert.;Gilbert H L Tang.;Simon Redwood.;Maurizio Taramasso.;Fabien Praz.;Neil Fam.;Nicolas Dumonteil.;Jean-François Obadia.;Ralph Stephan von Bardeleben.;Tanja K Rudolph.;Michael J Reardon.;Marco Metra.;Paolo Denti.;Michael J Mack.;Jörg Hausleiter.;Federico M Asch.;Azeem Latib.;JoAnn Lindenfeld.;Thomas Modine.;Gregg W Stone.;Juan F Granada.; .
来源: Circ Cardiovasc Interv. 2023年16卷6期e013045页
Transcatheter mitral valve replacement (TMVR) is an emerging therapeutic alternative for patients with secondary mitral regurgitation (MR). Outcomes of TMVR versus guideline-directed medical therapy (GDMT) have not been investigated for this population. This study aimed to compare clinical outcomes of patients with secondary MR undergoing TMVR versus GDMT alone.
4094. Correlation Between Fontan Pathway Diameter and Inferior-Superior Vena Cava Gradients in Adults Undergoing Exercise Catheterization.
作者: William R Miranda.;C Charles Jain.;Luke J Burchill.;Allison K Cabalka.;Donald J Hagler.;Christopher J Francois.;Heidi M Connolly.;Alexander C Egbe.
来源: Circ Cardiovasc Interv. 2023年16卷5期e012493页 4096. Clinical Presentation and Medium-Term Outcomes of Children With Anomalous Aortic Origin of the Left Coronary Artery: High-Risk Features Beyond Interarterial Course.
作者: Tam T Doan.;J Kevin Wilkes.;Dana L Reaves O'Neal.;Carlos Bonilla-Ramirez.;Shagun Sachdeva.;Prakash Masand.;Carlos M Mery.;Ziyad Binsalamah.;Jeffrey S Heinle.;Silvana Molossi.
来源: Circ Cardiovasc Interv. 2023年16卷5期e012635页
Anomalous aortic origin of the left coronary artery (AAOLCA) confers a rare, but significant, risk of sudden cardiac death in children. Surgery is recommended for interarterial AAOLCA, and other subtypes considered benign. We aimed to determine the clinical characteristics and outcomes of 3 AAOLCA subtypes.
4097. Transcatheter Aortic Valve Replacement in Patients With Reduced Ejection Fraction and Nonsevere Aortic Stenosis.
作者: Sebastian Ludwig.;Niklas Schofer.;Mohamed Abdel-Wahab.;Marina Urena.;Guillaume Jean.;Matthias Renker.;Christian W Hamm.;Holger Thiele.;Bernard Iung.;Joris F Ooms.;Maya Wiessman.;Nils S B Mogensen.;Benjamin Longère.;Nils Perrin.;Walid Ben Ali.;Augustin Coisne.;Jordi S Dahl.;Nicolas M Van Mieghem.;Ran Kornowski.;Won-Keun Kim.;Marie-Annick Clavel.
来源: Circ Cardiovasc Interv. 2023年16卷5期e012768页
The potential benefit of transcatheter aortic valve replacement (TAVR) in patients with nonsevere aortic stenosis (AS) and heart failure is controversial. This study aimed to assess outcomes of patients with nonsevere low-gradient AS (LGAS) and reduced left ventricular ejection fraction undergoing TAVR or medical management.
4098. Antithrombotic Management After Left Atrial Appendage Closure: Current Evidence and Future Perspectives.
作者: Jules Mesnier.;Pedro Cepas-Guillén.;Xavier Freixa.;Eduardo Flores-Umanzor.;Kim Hoang Trinh.;Gilles O'Hara.;Josep Rodés-Cabau.
来源: Circ Cardiovasc Interv. 2023年16卷5期e012812页
Left atrial appendage closure is an alternative to chronic oral anticoagulation to prevent embolic events related to nonvalvular atrial fibrillation. After device implantation, antithrombotic treatment is prescribed to prevent device-related thrombosis, a dreadful complication associated with an increased risk of ischemic events. However, the optimal antithrombotic treatment after left atrial appendage closure, effective on both device-related thrombus prevention and bleeding risk mitigation, remains to be determined. In more than 10 years experience with left atrial appendage closure, a wide range of antithrombotic treatments have been used, mostly in observational studies. In this review, we analyzed the body of evidence for each antithrombotic regimen after left atrial appendage closure to provide tools to guide the physician choice and describe future perspectives in the field.
4099. Transcatheter Aortic Valve Replacement and Impact of Subclinical Leaflet Thrombosis in Low-Risk Patients: LRT Trial 4-Year Outcomes.
作者: Ron Waksman.;Sukhdeep Bhogal.;Paul Gordon.;Afshin Ehsan.;Sean R Wilson.;Robert Levitt.;Puja Parikh.;Thomas Bilfinger.;Nicholas Hanna.;Maurice Buchbinder.;Federico M Asch.;Francis Y Kim.;Gaby Weissman.;Itsik Ben-Dor.;Christian C Shults.;Syed Ali.;Joseph A Sutton.;Corey Shea.;Cheng Zhang.;Hector M Garcia-Garcia.;Lowell F Satler.;Toby Rogers.
来源: Circ Cardiovasc Interv. 2023年16卷5期e012655页
The LRT trial (Low-Risk Transcatheter Aortic Valve Replacement [TAVR]) demonstrated the safety and feasibility of TAVR in low-risk patients, with excellent 1- and 2-year outcomes. The objective of the current study is to provide the overall clinical outcomes and the impact of 30-day hypoattenuated leaflet thickening (HALT) on structural valve deterioration at 4 years.
4100. Target Lesion Revascularization After Intravascular Ultrasound-Guided Percutaneous Coronary Intervention.
作者: Ko Yamamoto.;Hiroki Shiomi.;Takeshi Morimoto.;Akiyoshi Miyazawa.;Hiroki Watanabe.;Masahiro Natsuaki.;Hirotoshi Watanabe.;Kyohei Yamaji.;Masanobu Ohya.;Sunao Nakamura.;Satoru Mitomo.;Satoru Suwa.;Takenori Domei.;Shojiro Tatsushima.;Koh Ono.;Hiroki Sakamoto.;Kiyotaka Shimamura.;Masataka Shigetoshi.;Ryoji Taniguchi.;Yuji Nishimoto.;Hideki Okayama.;Kensho Matsuda.;Takafumi Yokomatsu.;Masahiro Muto.;Ren Kawaguchi.;Koichi Kishi.;Mitsuyoshi Hadase.;Tsutomu Fujita.;Yasunori Nishida.;Masami Nishino.;Hiromasa Otake.;Nobuhiro Suematsu.;Tsuneki Ajimi.;Kengo Tanabe.;Mitsuru Abe.;Kiyoshi Hibi.;Kazushige Kadota.;Kenji Ando.;Takeshi Kimura.; .
来源: Circ Cardiovasc Interv. 2023年16卷5期e012922页
Several stent expansion criteria derived from the intravascular ultrasound (IVUS) evaluation have been proposed to predict future clinical outcomes, but optimal stent expansion criteria as a guide during percutaneous coronary intervention (PCI) are still controversial. There are no studies evaluating the utility of stent expansion criteria along with the clinical and procedural factors in predicting target lesion revascularization (TLR) after contemporary IVUS-guided PCI.
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