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4061. Strategies for Treatment of Annular Rupture Complicating Transcatheter Aortic Valve Implantation: A Retrospective Analysis of the Bern TAVI Registry.
作者: Daijiro Tomii.;Thomas Pilgrim.;Taishi Okuno.;Jonas Lanz.;Fabien Praz.;Stefan Stortecky.;Matthias Siepe.;Stephan Windecker.;David Reineke.
来源: Circ Cardiovasc Interv. 2023年16卷6期e012796页 4062. Bestrophin3 Deficiency in Vascular Smooth Muscle Cells Activates MEKK2/3-MAPK Signaling to Trigger Spontaneous Aortic Dissection.
作者: Ting-Ting Zhang.;Qing-Qing Lei.;Jie He.;Xin Guan.;Xin Zhang.;Ying Huang.;Zi-Yue Zhou.;Rui-Xin Fan.;Ting Wang.;Chen-Xi Li.;Jin-Yan Shang.;Zhuo-Miao Lin.;Wan-Li Peng.;Li-Kai Xia.;Yu-Ling He.;Chuan-Ying Hong.;Jing-Song Ou.;Rui-Ping Pang.;Xiao-Ping Fan.;Hui Huang.;Jia-Guo Zhou.
来源: Circulation. 2023年148卷7期589-606页
Aortic dissection (AD) is a fatal cardiovascular disorder without effective medications due to unclear pathogenic mechanisms. Bestrophin3 (Best3), the predominant isoform of bestrophin family in vessels, has emerged as critical for vascular pathological processes. However, the contribution of Best3 to vascular diseases remains elusive.
4063. Dapagliflozin Improves Heart Failure Symptoms and Physical Limitations Across the Full Range of Ejection Fraction: Pooled Patient-Level Analysis From DEFINE-HF and PRESERVED-HF Trials.
作者: Michael E Nassif.;Sheryl L Windsor.;Kensey Gosch.;Barry A Borlaug.;Mansoor Husain.;Silvio E Inzucchi.;Dalane W Kitzman.;Darren K McGuire.;Bertram Pitt.;Benjamin M Scirica.;Sanjiv J Shah.;Guillermo Umpierrez.;Bethany A Austin.;Sumant Lamba.;Taiyeb Khumri.;Kavita Sharma.;Mikhail N Kosiborod.
来源: Circ Heart Fail. 2023年16卷7期e009837页
Patients with heart failure (HF) have a high burden of symptoms and physical limitations, regardless of ejection fraction (EF). Whether the benefits of SGLT2 (sodium-glucose cotransporter-2) inhibitors on these outcomes vary across the full range of EF remains unclear.
4064. Natural History of Hypertrophic Cardiomyopathy in Noonan Syndrome With Multiple Lentigines.
作者: Emanuele Monda.;Aaron Prosnitz.;Rossella Aiello.;Michele Lioncino.;Gabrielle Norrish.;Martina Caiazza.;Fabrizio Drago.;Meaghan Beattie.;Marco Tartaglia.;Maria Giovanna Russo.;Steven D Colan.;Giulio Calcagni.;Bruce D Gelb.;Juan Pablo Kaski.;Amy E Roberts.;Giuseppe Limongelli.
来源: Circ Genom Precis Med. 2023年16卷4期350-358页
We aimed to examine clinical features and outcomes of consecutive molecularly characterized patients with Noonan syndrome with multiple lentigines and hypertrophic cardiomyopathy.
4065. Genetic Burden of TNNI3K in Diagnostic Testing of Patients With Dilated Cardiomyopathy and Supraventricular Arrhythmias.
作者: Caroline Pham.;Karolina Andrzejczyk.;Sean J Jurgens.;Ronald Lekanne Deprez.;Kaylin C A Palm.;Alexa M C Vermeer.;Janneke Nijman.;Imke Christiaans.;Daniela Q C M Barge-Schaapveld.;Pascal F H M van Dessel.;Leander Beekman.;Seung Hoan Choi.;Steven A Lubitz.;Doris Skoric-Milosavljevic.;Lisa van den Bersselaar.;Philip R Jansen.;Jaël S Copier.;Patrick T Ellinor.;Arthur A M Wilde.;Connie R Bezzina.;Elisabeth M Lodder.
来源: Circ Genom Precis Med. 2023年16卷4期328-336页
Genetic variants in TNNI3K (troponin-I interacting kinase) have previously been associated with dilated cardiomyopathy (DCM), cardiac conduction disease, and supraventricular tachycardias. However, the link between TNNI3K variants and these cardiac phenotypes shows a lack of consensus concerning phenotype and protein function.
4066. Safety and Effectiveness of Pulsed Field Ablation to Treat Atrial Fibrillation: One-Year Outcomes From the MANIFEST-PF Registry.
作者: Mohit K Turagam.;Petr Neuzil.;Boris Schmidt.;Tobias Reichlin.;Kars Neven.;Andreas Metzner.;Jim Hansen.;Yuri Blaauw.;Philippe Maury.;Thomas Arentz.;Philipp Sommer.;Ante Anic.;Frédéric Anselme.;Serge Boveda.;Tom Deneke.;Stephan Willems.;Pepijn van der Voort.;Roland Tilz.;Moritoshi Funasako.;Daniel Scherr.;Reza Wakili.;Daniel Steven.;Josef Kautzner.;Johan Vijgen.;Pierre Jais.;Jan Petru.;Julian Chun.;Laurent Roten.;Anna Füting.;Marc D Lemoine.;Martin Ruwald.;Bart A Mulder.;Anne Rollin.;Heiko Lehrmann.;Thomas Fink.;Zrinka Jurisic.;Corentin Chaumont.;Raquel Adeliño.;Karin Nentwich.;Melanie Gunawardene.;Alexandre Ouss.;Christian-Hendrik Heeger.;Martin Manninger.;Jan-Eric Bohnen.;Arian Sultan.;Petr Peichl.;Pieter Koopman.;Nicolas Derval.;Thomas Kueffer.;Gilbert Rahe.;Vivek Y Reddy.
来源: Circulation. 2023年148卷1期35-46页
Pulsed field ablation is a novel nonthermal cardiac ablation modality using ultra-rapid electrical pulses to cause cell death by a mechanism of irreversible electroporation. Unlike the traditional ablation energy sources, pulsed field ablation has demonstrated significant preferentiality to myocardial tissue ablation, and thus avoids certain thermally mediated complications. However, its safety and effectiveness remain unknown in usual clinical care.
4067. INKILN is a Novel Long Noncoding RNA Promoting Vascular Smooth Muscle Inflammation via Scaffolding MKL1 and USP10.
作者: Wei Zhang.;Jinjing Zhao.;Lin Deng.;Nestor Ishimwe.;Jessica Pauli.;Wen Wu.;Shengshuai Shan.;Wolfgang Kempf.;Margaret D Ballantyne.;David Kim.;Qing Lyu.;Matthew Bennett.;Julie Rodor.;Adam W Turner.;Yao Wei Lu.;Ping Gao.;Mihyun Choi.;Ganesh Warthi.;Ha Won Kim.;Margarida M Barroso.;William B Bryant.;Clint L Miller.;Neal L Weintraub.;Lars Maegdefessel.;Joseph M Miano.;Andrew H Baker.;Xiaochun Long.
来源: Circulation. 2023年148卷1期47-67页
Activation of vascular smooth muscle cell (VSMC) inflammation is vital to initiate vascular disease. The role of human-specific long noncoding RNAs in VSMC inflammation is poorly understood.
4068. Retained Metabolic Flexibility of the Failing Human Heart.
作者: William D Watson.;Peregrine G Green.;Andrew J M Lewis.;Per Arvidsson.;Giovanni Luigi De Maria.;Håkan Arheden.;Einar Heiberg.;William T Clarke.;Christopher T Rodgers.;Ladislav Valkovič.;Stefan Neubauer.;Neil Herring.;Oliver J Rider.
来源: Circulation. 2023年148卷2期109-123页
The failing heart is traditionally described as metabolically inflexible and oxygen starved, causing energetic deficit and contractile dysfunction. Current metabolic modulator therapies aim to increase glucose oxidation to increase oxygen efficiency of adenosine triphosphate production, with mixed results.
4069. Shorter Door-to-Needle Times Are Associated With Better Outcomes After Intravenous Thrombolytic Therapy and Endovascular Thrombectomy for Acute Ischemic Stroke.
作者: Shumei Man.;Nicole Solomon.;Brian Mac Grory.;Brooke Alhanti.;Ken Uchino.;Jeffrey L Saver.;Eric E Smith.;Ying Xian.;Deepak L Bhatt.;Lee H Schwamm.;Muhammad Shazam Hussain.;Gregg C Fonarow.
来源: Circulation. 2023年148卷1期20-34页
Existing data and clinical trials could not determine whether faster intravenous thrombolytic therapy (IVT) translates into better long-term functional outcomes after acute ischemic stroke among those treated with endovascular thrombectomy (EVT). Patient-level national data can provide the required large population to study the associations between earlier IVT, versus later, with longitudinal functional outcomes and mortality in patients receiving IVT+EVT combined treatment.
4070. Rare Genetic Variants Associated With Sudden Cardiac Arrest in the Young: A Prospective, Population-Based Study.
作者: Lauri Holmstrom.;Ninad S Chaudhary.;Kotoka Nakamura.;Harpriya Chugh.;Audrey Uy-Evanado.;Faye Norby.;Ginger A Metcalf.;Vipin K Menon.;Bing Yu.;Eric Boerwinkle.;Sumeet S Chugh.;Zeynep Akdemir.;Evan P Kransdorf.
来源: Circ Genom Precis Med. 2023年16卷4期404-405页 4071. Right Ventricular Sarcomere Contractile Depression and the Role of Thick Filament Activation in Human Heart Failure With Pulmonary Hypertension.
作者: Vivek Jani.;M Imran Aslam.;Axel J Fenwick.;Weikang Ma.;Henry Gong.;Gregory Milburn.;Devin Nissen.;Ilton M Cubero Salazar.;Olivia Hanselman.;Monica Mukherjee.;Marc K Halushka.;Kenneth B Margulies.;Kenneth S Campbell.;Thomas C Irving.;David A Kass.;Steven Hsu.
来源: Circulation. 2023年147卷25期1919-1932页
Right ventricular (RV) contractile dysfunction commonly occurs and worsens outcomes in patients with heart failure with reduced ejection fraction and pulmonary hypertension (HFrEF-PH). However, such dysfunction often goes undetected by standard clinical RV indices, raising concerns that they may not reflect aspects of underlying myocyte dysfunction. We thus sought to characterize RV myocyte contractile depression in HFrEF-PH, identify those components reflected by clinical RV indices, and uncover underlying biophysical mechanisms.
4072. Prevalence of Pathogenic Variants in Dilated Cardiomyopathy-Associated Genes in Patients Evaluated for Cardiac Sarcoidosis.
作者: Nosheen Reza.;Michael G Levin.;Mahesh K Vidula.;Paco E Bravo.;Scott M Damrauer.;Marylyn D Ritchie.; .;C Anwar A Chahal.;Anjali Tiku Owens.
来源: Circ Genom Precis Med. 2023年16卷4期409-411页 4073. Combined Clinical, Molecular, and Muscle Biopsy Approach to Unveil Prevalence and Clinical Features of Rare Neuromuscular and Mitochondrial Diseases in Patients With Cardiomyopathies.
作者: Michele Lioncino.;Emanuele Monda.;Martina Caiazza.;Vincenzo Simonelli.;Claudia Nesti.;Alfredo Mauriello.;Alberta Budillon.;Alessandro Di Santo.;Giorgia Bruno.;Antonio Varone.;Vincenzo Nigro.;Filippo Maria Santorelli.;Giuseppe Pacileo.;Maria Giovanna Russo.;Giulia Frisso.;Simone Sampaolo.;Giuseppe Limongelli.
来源: Circ Genom Precis Med. 2023年16卷4期412-414页 4074. KIDS SAVE LIVES: Basic Life Support Education for Schoolchildren: A Narrative Review and Scientific Statement From the International Liaison Committee on Resuscitation.
作者: Daniel C Schroeder.;Federico Semeraro.;Robert Greif.;Janet Bray.;Peter Morley.;Michael Parr.;Naomi Kondo Nakagawa.;Taku Iwami.;Simon-Richard Finke.;Carolina Malta Hansen.;Andrew Lockey.;Marina Del Rios.;Farhan Bhanji.;Comilla Sasson.;Stephen M Schexnayder.;Tommaso Scquizzato.;Wolfgang A Wetsch.;Bernd W Böttiger.; .
来源: Circulation. 2023年147卷24期1854-1868页
Basic life support education for schoolchildren has become a key initiative to increase bystander cardiopulmonary resuscitation rates. Our objective was to review the existing literature on teaching schoolchildren basic life support to identify the best practices to provide basic life support training in schoolchildren.
4076. Transcatheter Mitral Valve Replacement Versus Medical Therapy for Secondary Mitral Regurgitation: A Propensity Score-Matched Comparison.
作者: Sebastian Ludwig.;Lenard Conradi.;David J Cohen.;Augustin Coisne.;Andrea Scotti.;William T Abraham.;Walid Ben Ali.;Zhipeng Zhou.;Yanru Li.;Saibal Kar.;Alison Duncan.;D Scott Lim.;Marianna Adamo.;Björn Redfors.;David W M Muller.;John G Webb.;Anna S Petronio.;Hendrik Ruge.;Georg Nickenig.;Lars Sondergaard.;Matti Adam.;Damiano Regazzoli.;Andrea Garatti.;Tobias Schmidt.;Martin Andreas.;Gry Dahle.;Thomas Walther.;Joerg Kempfert.;Gilbert H L Tang.;Simon Redwood.;Maurizio Taramasso.;Fabien Praz.;Neil Fam.;Nicolas Dumonteil.;Jean-François Obadia.;Ralph Stephan von Bardeleben.;Tanja K Rudolph.;Michael J Reardon.;Marco Metra.;Paolo Denti.;Michael J Mack.;Jörg Hausleiter.;Federico M Asch.;Azeem Latib.;JoAnn Lindenfeld.;Thomas Modine.;Gregg W Stone.;Juan F Granada.; .
来源: Circ Cardiovasc Interv. 2023年16卷6期e013045页
Transcatheter mitral valve replacement (TMVR) is an emerging therapeutic alternative for patients with secondary mitral regurgitation (MR). Outcomes of TMVR versus guideline-directed medical therapy (GDMT) have not been investigated for this population. This study aimed to compare clinical outcomes of patients with secondary MR undergoing TMVR versus GDMT alone.
4078. Correlation Between Fontan Pathway Diameter and Inferior-Superior Vena Cava Gradients in Adults Undergoing Exercise Catheterization.
作者: William R Miranda.;C Charles Jain.;Luke J Burchill.;Allison K Cabalka.;Donald J Hagler.;Christopher J Francois.;Heidi M Connolly.;Alexander C Egbe.
来源: Circ Cardiovasc Interv. 2023年16卷5期e012493页 4080. Clinical Presentation and Medium-Term Outcomes of Children With Anomalous Aortic Origin of the Left Coronary Artery: High-Risk Features Beyond Interarterial Course.
作者: Tam T Doan.;J Kevin Wilkes.;Dana L Reaves O'Neal.;Carlos Bonilla-Ramirez.;Shagun Sachdeva.;Prakash Masand.;Carlos M Mery.;Ziyad Binsalamah.;Jeffrey S Heinle.;Silvana Molossi.
来源: Circ Cardiovasc Interv. 2023年16卷5期e012635页
Anomalous aortic origin of the left coronary artery (AAOLCA) confers a rare, but significant, risk of sudden cardiac death in children. Surgery is recommended for interarterial AAOLCA, and other subtypes considered benign. We aimed to determine the clinical characteristics and outcomes of 3 AAOLCA subtypes.
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