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4022. Balanced crystalloid solution versus saline in deceased donor kidney transplantation (BEST-Fluids): a pragmatic, double-blind, randomised, controlled trial.
作者: Michael G Collins.;Magid A Fahim.;Elaine M Pascoe.;Carmel M Hawley.;David W Johnson.;Julie Varghese.;Laura E Hickey.;Philip A Clayton.;Kathryn B Dansie.;Rachael C McConnochie.;Liza A Vergara.;Charani Kiriwandeniya.;Donna Reidlinger.;Peter F Mount.;Laurence Weinberg.;Colin J McArthur.;P Toby Coates.;Zoltan H Endre.;David Goodman.;Kirsten Howard.;Martin Howell.;Jagadish S Jamboti.;John Kanellis.;Jerome M Laurence.;Wai H Lim.;Steven J McTaggart.;Philip J O'Connell.;Helen L Pilmore.;Germaine Wong.;Steven J Chadban.; .; .
来源: Lancet. 2023年402卷10396期105-117页
Delayed graft function (DGF) is a major adverse complication of deceased donor kidney transplantation. Intravenous fluids are routinely given to patients receiving a transplant to maintain intravascular volume and optimise graft function. Saline (0·9% sodium chloride) is widely used but might increase the risk of DGF due to its high chloride content. We aimed to test our hypothesis that using a balanced low-chloride crystalloid solution (Plasma-Lyte 148) instead of saline would reduce the incidence of DGF.
4024. Fruquintinib versus placebo in patients with refractory metastatic colorectal cancer (FRESCO-2): an international, multicentre, randomised, double-blind, phase 3 study.
作者: Arvind Dasari.;Sara Lonardi.;Rocio Garcia-Carbonero.;Elena Elez.;Takayuki Yoshino.;Alberto Sobrero.;James Yao.;Pilar García-Alfonso.;Judit Kocsis.;Antonio Cubillo Gracian.;Andrea Sartore-Bianchi.;Taroh Satoh.;Violaine Randrian.;Jiri Tomasek.;Geoff Chong.;Andrew Scott Paulson.;Toshiki Masuishi.;Jeremy Jones.;Tibor Csőszi.;Chiara Cremolini.;Francois Ghiringhelli.;Ardaman Shergill.;Howard S Hochster.;John Krauss.;Ali Bassam.;Michel Ducreux.;Anneli Elme.;Laurence Faugeras.;Stefan Kasper.;Eric Van Cutsem.;Dirk Arnold.;Shivani Nanda.;Zhao Yang.;William R Schelman.;Marek Kania.;Josep Tabernero.;Cathy Eng.; .
来源: Lancet. 2023年402卷10395期41-53页
There is a paucity of effective systemic therapy options for patients with advanced, chemotherapy-refractory colorectal cancer. We aimed to evaluate the efficacy and safety of fruquintinib, a highly selective and potent oral inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2, and 3, in patients with heavily pretreated metastatic colorectal cancer.
4025. Self-administered intranasal etripamil using a symptom-prompted, repeat-dose regimen for atrioventricular-nodal-dependent supraventricular tachycardia (RAPID): a multicentre, randomised trial.
作者: Bruce S Stambler.;A John Camm.;Marco Alings.;Paul Dorian.;Hein Heidbuchel.;Jaco Houtgraaf.;Peter R Kowey.;Jose L Merino.;Blandine Mondésert.;Jonathan P Piccini.;Sean D Pokorney.;Philip T Sager.;Atul Verma.;J Marcus Wharton.;David B Bharucha.;Francis Plat.;Silvia Shardonofsky.;Michael Chen.;James E Ip.; .
来源: Lancet. 2023年402卷10396期118-128页
Etripamil is a fast-acting, intranasally administered calcium-channel blocker in development for on-demand therapy outside a health-care setting for paroxysmal supraventricular tachycardia. We aimed to evaluate the efficacy and safety of etripamil 70 mg nasal spray using a symptom-prompted, repeat-dose regimen for acute conversion of atrioventricular-nodal-dependent paroxysmal supraventricular tachycardia to sinus rhythm within 30 min.
4028. Health outcomes of the G7 Hiroshima Summit: breaking the cycle of panic and neglect and achieving UHC.
作者: Satoshi Ezoe.;Jin Hashimoto.;Yuichiro Nishida.;Hokuto Namikawa.;Makiko Yoneda.;Satomi Ichino.;Sae Tanaka.;Takahiro Ohmori.;Maiko Oya.;Natsuko Hatano.;Eiji Hinoshita.;Keiichi Hara.;Naoki Ito.;Takeshi Akahori.
来源: Lancet. 2023年401卷10394期2091-2093页 |