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3961. Graft dysfunction in compassionate use of genetically engineered pig-to-human cardiac xenotransplantation: a case report.
作者: Muhammad M Mohiuddin.;Avneesh K Singh.;Linda Scobie.;Corbin E Goerlich.;Alison Grazioli.;Kapil Saharia.;Claire Crossan.;Allen Burke.;Cinthia Drachenberg.;Cihan Oguz.;Tianshu Zhang.;Billeta Lewis.;Alena Hershfeld.;Faith Sentz.;Ivan Tatarov.;Sarah Mudd.;Gheorghe Braileanu.;Kathryn Rice.;John F Paolini.;Kent Bondensgaard.;Todd Vaught.;Kasinath Kuravi.;Lori Sorrells.;Amy Dandro.;David Ayares.;Christine Lau.;Bartley P Griffith.
来源: Lancet. 2023年402卷10399期397-410页
A genetically engineered pig cardiac xenotransplantation was done on Jan 7, 2022, in a non-ambulatory male patient, aged 57 years, with end-stage heart failure, and on veno-arterial extracorporeal membrane oxygenation support, who was ineligible for an allograft. This report details our current understanding of factors important to the xenotransplantation outcome.
3962. Planned delivery or expectant management for late preterm pre-eclampsia in low-income and middle-income countries (CRADLE-4): a multicentre, open-label, randomised controlled trial.
作者: Alice Beardmore-Gray.;Nicola Vousden.;Paul T Seed.;Bellington Vwalika.;Sebastian Chinkoyo.;Victor Sichone.;Alexander B Kawimbe.;Umesh Charantimath.;Geetanjali Katageri.;Mrutyunjaya B Bellad.;Laxmikant Lokare.;Kasturi Donimath.;Shailaja Bidri.;Shivaprasad Goudar.;Jane Sandall.;Lucy C Chappell.;Andrew H Shennan.; .
来源: Lancet. 2023年402卷10399期386-396页
Pre-eclampsia is a leading cause of maternal and perinatal mortality. Evidence regarding interventions in a low-income or middle-income setting is scarce. We aimed to evaluate whether planned delivery between 34+ 0 and 36+ 6 weeks' gestation can reduce maternal mortality and morbidity without increasing perinatal complications in India and Zambia.
3977. Opioid analgesia for acute low back pain and neck pain (the OPAL trial): a randomised placebo-controlled trial.
作者: Caitlin M P Jones.;Richard O Day.;Bart W Koes.;Jane Latimer.;Chris G Maher.;Andrew J McLachlan.;Laurent Billot.;Sana Shan.;Chung-Wei Christine Lin.; .
来源: Lancet. 2023年402卷10398期304-312页
Opioid analgesics are commonly used for acute low back pain and neck pain, but supporting efficacy data are scarce. We aimed to investigate the efficacy and safety of a judicious short course of an opioid analgesic for acute low back pain and neck pain.
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