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3921. The role of high serum triglyceride levels on pancreatic necrosis development and related complications.
作者: Nils Jimmy Hidalgo.;Elizabeth Pando.;Piero Alberti.;Rodrigo Mata.;Nair Fernandes.;Montse Adell.;Sara Villasante.;Laia Blanco.;Joaquim Balsells.;Ramon Charco.
来源: BMC Gastroenterol. 2023年23卷1期51页
The relevance of elevated serum triglyceride (TG) levels in the early stages of acute pancreatitis (AP) not induced by hypertriglyceridemia (HTG) remains unclear. Our study aims to determine the role of elevated serum TG levels at admission in developing pancreatic necrosis.
3922. Interactive training versus self-driven training in the prediction of colorectal polyp histology by trainees using the NICE classification.
The COVID-19 pandemic has impacted endoscopic training of the Narrow Band Imaging International Colorectal Endoscopic (NICE) classification, which could accurately predict pathology of colorectal polyps. This study aimed to evaluate the diagnostic performance by trainees of self-driven training vs. interactive training in the prediction of colorectal polyp histology.
3923. Correction: Experimental non-alcoholic fatty liver disease causes regional liver functional deficits as measured by the capacity for galactose metabolism while whole liver function is preserved.
作者: Peter Lykke Eriksen.;Karen Louise Thomsen.;Stephen Hamilton-Dutoit.;Hendrik Vilstrup.;Michael Sørensen.
来源: BMC Gastroenterol. 2023年23卷1期49页 3924. ARL9 is upregulated and serves as a biomarker for a poor prognosis in colon adenocarcinoma.
作者: Hai-Deng Yang.;Xiu-Xiu Jin.;Bin-Bin Gu.; Yu-Zhang.;Dan Li.;Ling-Ling Yan.
来源: BMC Gastroenterol. 2023年23卷1期48页
ARL9 is a newly identified member of the ARF family, and the clinical significance of ARL9 in colon adenocarcinoma is unknown. In this study, we aimed to explore the expression of ARL9 mRNA in colon adenocarcinoma, and its effect on the prognosis of patients with colon adenocarcinoma.
3925. AGA Clinical Practice Guideline on the Role of Biomarkers for the Management of Ulcerative Colitis.
作者: Siddharth Singh.;Ashwin N Ananthakrishnan.;Nghia H Nguyen.;Benjamin L Cohen.;Fernando S Velayos.;Jennifer M Weiss.;Shahnaz Sultan.;Shazia M Siddique.;Jeremy Adler.;Karen A Chachu.; .
来源: Gastroenterology. 2023年164卷3期344-372页
Biomarkers are used frequently for noninvasive monitoring and treatment decision making in the management of patients with ulcerative colitis (UC). This American Gastroenterological Association (AGA) guideline is intended to support practitioners in decisions about the use of biomarkers for the management of UC.
3927. Randomized Placebo-Controlled Phase 3 Trial of Vibrating Capsule for Chronic Constipation.
作者: Satish S C Rao.;Eamonn M M Quigley.;William D Chey.;Amol Sharma.;Anthony J Lembo.
来源: Gastroenterology. 2023年164卷7期1202-1210.e6页
Despite therapeutic advances, effective treatments for chronic constipation remain an unmet need. The vibrating capsule is a nonpharmacologic, orally ingested, programmable capsule that vibrates intraluminally to induce bowel movements. We aimed to determine the efficacy and safety of the vibrating capsule in patients with chronic constipation.
3928. Frequency, outcomes, and need for intervention in stricturing gastrointestinal tuberculosis: a systematic review and meta-analysis.
作者: Anuraag Jena.;Ritin Mohindra.;Kirtan Rana.;Pardhu B Neelam.;Dhuni Chand Thakur.;Harjeet Singh.;Pankaj Gupta.;Vikas Suri.;Vishal Sharma.
来源: BMC Gastroenterol. 2023年23卷1期46页
Gastrointestinal strictures impact clinical presentation in abdominal tuberculosis and are associated with significant morbidity.
3929. The global, regional, and national burden of appendicitis in 204 countries and territories, 1990-2019: a systematic analysis from the Global Burden of Disease Study 2019.
作者: Linjing Guan.;Zhen Liu.;Guangdong Pan.;Bulin Zhang.;Yongrong Wu.;Tao Gan.;Guoqing Ouyang.
来源: BMC Gastroenterol. 2023年23卷1期44页
Appendicitis is the most common abdominal surgical emergency worldwide, and its burden has been changing. We report the level and trends of appendicitis prevalence, and incidence; and years lived with disability (YLD) in 204 countries and territories from 1990 to 2019, based on data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019.
3930. Personalized colorectal cancer screening: study protocol of a mixed-methods study on the effectiveness of tailored intervals based on prior f-Hb concentration in a fit-based colorectal cancer screening program (PERFECT-FIT).
作者: Emilie C H Breekveldt.;Esther Toes-Zoutendijk.;Lucie de Jonge.;Manon C W Spaander.;Evelien Dekker.;Folkert J van Kemenade.;Anneke J van Vuuren.;Christian R B Ramakers.;Iris D Nagtegaal.;Monique E van Leerdam.;Iris Lansdorp-Vogelaar.
来源: BMC Gastroenterol. 2023年23卷1期45页
In 2014, the national population-based colorectal cancer (CRC) screening program was implemented in the Netherlands. Biennial fecal immunochemical testing (FIT) for hemoglobin (Hb) is used at a cut-off of 47 µg Hb per gram feces. The CRC screening program successfully started, with high participation rates and yield of screening. Now that the program has reached a steady state, there is potential to further optimize the program. Previous studies showed that prior fecal Hb (f-Hb) concentrations just below the FIT cut-off are associated with a higher risk for detection of advanced neoplasia (AN) at subsequent screening rounds. We aim to achieve a better balance between the harms and benefits of CRC screening by offering participants tailored invitation intervals based on prior f-Hb concentrations after negative FIT.
3931. Hydroxyphenylpyruvate Dioxygenase Is a Metabolic Immune Checkpoint for UTX-deficient Colorectal Cancer.
作者: ZunGuo Du.;JunHui Su.;ShengLi Lin.;Tao Chen.;WenChao Gao.;MengHui Wang.;YueHeng Li.;Dong Wei.;ZhiQian Hu.;ChunFang Gao.;QingQuan Li.
来源: Gastroenterology. 2023年164卷7期1165-1179.e13页
Aberrant epigenetic events mediated by histone methyltransferases and demethylases contribute to malignant progression of colorectal cancer (CRC). However, the role of the histone demethylase ubiquitously transcribed tetratricopeptide repeat on chromosome X (UTX) in CRC remains poorly understood.
3934. Pancreatic Cancer: Changing Epidemiology and New Approaches to Risk Assessment, Early Detection, and Prevention.
Pancreatic cancer usually results in poor survival with limited options for treatment, as most affected individuals present with advanced disease. Early detection of preinvasive pancreatic neoplasia and identifying molecular therapeutic targets provide opportunities for extending survival. Although screening for pancreatic cancer is currently not recommended for the general population, emerging evidence indicates that pancreatic surveillance can improve outcomes for individuals in certain high-risk groups. Changes in the epidemiology of pancreatic cancer, experience from pancreatic surveillance, and discovery of novel biomarkers provide a roadmap for new strategies for pancreatic cancer risk assessment, early detection, and prevention.
3937. A comprehensive computational analysis to explore the importance of SIGLECs in HCC biology.
作者: Senbang Yao.;Wenjun Chen.;Tingting Chen.;He Zuo.;Ziran Bi.;Xiuqing Zhang.;Lulian Pang.;Yanyan Jing.;Xiangxiang Yin.;Huaidong Cheng.
来源: BMC Gastroenterol. 2023年23卷1期42页
Hepatocellular carcinoma (HCC) is an aggressive, malignant cancer with a complex pathogenesis. However, effective therapeutic targets and prognostic biomarkers are limited. Sorafenib provides delaying cancer progression and survival improvement in advanced HCC. But despite 10 years of research on the clinical application of sorafenib, predictive markers for its therapeutic effect are lacking.
3940. RNA Sequencing Identifies Frequent Mitogen-activated Protein Kinase-associated Fusion Genes in Intraductal Tubulopapillary Neoplasms of the Pancreas.
作者: Jae W Lee.;Ralph H Hruban.;Lodewijk A A Brosens.;Vincenzo Condello.;Marina N Nikiforova.;Aatur D Singhi.; .
来源: Gastroenterology. 2023年164卷7期1310-1313.e6页 |