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3722. Associations of Apixaban Dose With Safety and Effectiveness Outcomes in Patients With Atrial Fibrillation and Severe Chronic Kidney Disease.
作者: Yunwen Xu.;Alexander R Chang.;Lesley A Inker.;Mara McAdams-DeMarco.;Morgan E Grams.;Jung-Im Shin.
来源: Circulation. 2023年148卷19期1445-1454页
Recommendations for apixaban dosing on the basis of kidney function are inconsistent between the US Food and Drug Administration and European Medicines Agency for patients with atrial fibrillation. Optimal apixaban dosing in chronic kidney disease remains unknown.
3723. Changes in Cardiovascular Spending, Care Utilization, and Clinical Outcomes Associated With Participation in Bundled Payments for Care Improvement - Advanced.
作者: Sukruth A Shashikumar.;Jie Zheng.;E John Orav.;Arnold M Epstein.;Karen E Joynt Maddox.
来源: Circulation. 2023年148卷14期1074-1083页
Bundled Payments for Care Improvement - Advanced (BPCI-A) is a Medicare initiative that aims to incentivize reductions in spending for episodes of care that start with a hospitalization and end 90 days after discharge. Cardiovascular disease, an important driver of Medicare spending, is one of the areas of focus BPCI-A. It is unknown whether BPCI-A is associated with spending reductions or quality improvements for the 3 cardiovascular medical events or 5 cardiovascular procedures in the model.
3724. Clonal Hematopoiesis in Clinical and Experimental Heart Failure With Preserved Ejection Fraction.
作者: Jesse D Cochran.;Yoshimitsu Yura.;Mark C Thel.;Heather Doviak.;Ariel H Polizio.;Yuka Arai.;Yohei Arai.;Keita Horitani.;Eunbee Park.;Nicholas W Chavkin.;Anupreet Kour.;Soichi Sano.;Nitin Mahajan.;Megan Evans.;Mahalia Huba.;Nadia Martinez Naya.;Hanna Sun.;Young Ho Ban.;Karen K Hirschi.;Stefano Toldo.;Antonio Abbate.;Todd E Druley.;Frederick L Ruberg.;Mathew S Maurer.;Justin A Ezekowitz.;Jason R B Dyck.;Kenneth Walsh.
来源: Circulation. 2023年148卷15期1165-1178页
Clonal hematopoiesis (CH), which results from an array of nonmalignant driver gene mutations, can lead to altered immune cell function and chronic disease, and has been associated with worse outcomes in patients with heart failure (HF) with reduced ejection fraction. However, the role of CH in the prognosis of HF with preserved ejection fraction (HFpEF) has been understudied. This study aimed to characterize CH in patients with HFpEF and elucidate its causal role in a murine model.
3725. Low-Cost High-Throughput Genotyping for Diagnosing Familial Hypercholesterolemia.
作者: Shirin Ibrahim.;Jeroen van Rooij.;Annemieke J M H Verkerk.;Jard de Vries.;Linda Zuurbier.;Joep Defesche.;Jorge Peter.;Willemijn A M Schonck.;Bahar Sedaghati-Khayat.;G Kees Hovingh.;André G Uitterlinden.;Erik S G Stroes.;Laurens F Reeskamp.
来源: Circ Genom Precis Med. 2023年16卷5期462-469页
Familial hypercholesterolemia (FH) is a common but underdiagnosed genetic disorder characterized by high low-density lipoprotein cholesterol levels and premature cardiovascular disease. Current sequencing methods to diagnose FH are expensive and time-consuming. In this study, we evaluated the accuracy of a low-cost, high-throughput genotyping array for diagnosing FH.
3726. Long-Term Effects of Pulmonary Endarterectomy on Right Ventricular Stiffness and Fibrosis in Chronic Thromboembolic Pulmonary Hypertension.
作者: Natalia J Braams.;Azar Kianzad.;Jessie van Wezenbeek.;Jeroen N Wessels.;Samara M A Jansen.;Stine Andersen.;Anco Boonstra.;Esther J Nossent.;J Tim Marcus.;Ahmed A Bayoumy.;Clarissa Becher.;Marie-José Goumans.;Asger Andersen.;Anton Vonk Noordegraaf.;Frances S de Man.;Harm Jan Bogaard.;Lilian J Meijboom.
来源: Circ Heart Fail. 2023年16卷10期e010336页
Surgical removal of thromboembolic material by pulmonary endarterectomy (PEA) leads within months to the improvement of right ventricular (RV) function in the majority of patients with chronic thromboembolic pulmonary hypertension. However, RV mass does not always normalize. It is unknown whether incomplete reversal of RV remodeling results from extracellular matrix expansion (diffuse interstitial fibrosis) or cellular hypertrophy, and whether residual RV remodeling relates to altered diastolic function.
3727. Contiguous Gene Deletion of Chromosome 15q25.2q25.3 in Biallelic ALPK3-Related Cardiomyopathy: Novel Insights Into Phenotypic Presentation and Variant Spectrum.
作者: Laura A Grutters.;Jolien S Klein Wassink-Ruiter.;Trijnie Dijkhuizen.;Hessel P Nijenhuis.;Jan D H Jongbloed.;Johanna C Herkert.
来源: Circ Genom Precis Med. 2023年16卷5期493-495页 3728. Cost-Effectiveness of Vericiguat in Patients With Heart Failure With Reduced Ejection Fraction: The VICTORIA Randomized Clinical Trial.
作者: Derek S Chew.;Yanhong Li.;Robert Bigelow.;Patricia A Cowper.;Kevin J Anstrom.;Melanie R Daniels.;Linda Davidson-Ray.;Adrian F Hernandez.;Christopher M O'Connor.;Paul W Armstrong.;Daniel B Mark.; .
来源: Circulation. 2023年148卷14期1087-1098页
The VICTORIA trial (Vericiguat Global Study in Subjects With Heart Failure With Reduced Ejection Fraction) demonstrated that, in patients with high-risk heart failure, vericiguat reduced the primary composite outcome of cardiovascular death or heart failure hospitalization relative to placebo. The hazard ratio for all-cause mortality was 0.95 (95% CI, 0.84-1.07). In a prespecified analysis, treatment effects varied substantially as a function of baseline NT-proBNP (N-terminal pro-B-type natriuretic peptide) levels, with survival benefit for vericiguat in the lower NT-proBNP quartiles (hazard ratio, 0.82 [95% CI, 0.69-0.97]) and no benefit in the highest NT-proBNP quartile (hazard ratio, 1.14 [95% CI, 0.95-1.38]). An economic analysis was a major secondary objective of the VICTORIA research program.
3729. DMD-Associated Dilated Cardiomyopathy: Genotypes, Phenotypes, and Phenocopies.
作者: Renee Johnson.;Robyn Otway.;Ephrem Chin.;Claire Horvat.;Monique Ohanian.;Jon A L Wilcox.;Zheng Su.;Priscilla Prestes.;Andrei Smolnikov.;Magdalena Soka.;Guanglan Guo.;Emma Rath.;Samya Chakravorty.;Lukasz Chrzanowski.;Christopher S Hayward.;Anne M Keogh.;Peter S Macdonald.;Eleni Giannoulatou.;Alex C Y Chang.;Emily C Oates.;Fadi Charchar.;Jonathan G Seidman.;Christine E Seidman.;Madhuri Hegde.;Diane Fatkin.
来源: Circ Genom Precis Med. 2023年16卷5期421-430页
Variants in the DMD gene, that encodes the cytoskeletal protein, dystrophin, cause a severe form of dilated cardiomyopathy (DCM) associated with high rates of heart failure, heart transplantation, and ventricular arrhythmias. Improved early detection of individuals at risk is needed.
3731. Letter by Zhu et al Regarding Article, "Disruption of Phosphodiesterase 3A Binding to SERCA2 Increases SERCA2 Activity and Reduces Mortality in Mice With Chronic Heart Failure".3732. Response by Aronsen et al to Letter Regarding Article, "Disruption of Phosphodiesterase 3A Binding to SERCA2 Increases SERCA2 Activity and Reduces Mortality in Mice With Chronic Heart Failure".
作者: Jan Magnus Aronsen.;Jonas Skogestad.;Ingrid Albert.;Arne Olav Melleby.;Cathrine R Carlson.
来源: Circulation. 2023年148卷10期857-858页 3736. Classification and Predictors of Right Ventricular Functional Recovery in Pulmonary Arterial Hypertension.
作者: Franz P Rischard.;Roberto J Bernardo.;Rebecca R Vanderpool.;Deborah H Kwon.;Tushar Acharya.;Margaret M Park.;Austin Katrynuik.;Michael Insel.;Saad Kubba.;Roberto Badagliacca.;A Brett Larive.;Robert Naeije.;Joe G N Garcia.;Gerald J Beck.;Serpil C Erzurum.;Robert P Frantz.;Paul M Hassoun.;Anna R Hemnes.;Nicholas S Hill.;Evelyn M Horn.;Jane A Leopold.;Erika B Rosenzweig.;W H Wilson Tang.;Jennifer D Wilcox.
来源: Circ Heart Fail. 2023年16卷10期e010555页
Normative changes in right ventricular (RV) structure and function have not been characterized in the context of treatment-associated functional recovery (RV functional recovery [RVFnRec]). The aim of this study is to assess the clinical relevance of a proposed RVFnRec definition.
3738. Feasibility of Simultaneous Quantification of Myocardial and Renal Perfusion With Cardiac Positron Emission Tomography.
作者: Jenifer M Brown.;Mi-Ae Park.;Marie Foley Kijewski.;Brittany N Weber.;Yihe Yang.;Laurel Martell.;Anna Perillo.;Leanne Barrett.;Sean Parks.;Jon Hainer.;Sharmila Dorbala.;Ron Blankstein.;Marcelo F Di Carli.
来源: Circ Cardiovasc Imaging. 2023年16卷9期e015324页
Given the central importance of cardiorenal interactions, mechanistic tools for evaluating cardiorenal physiology are needed. In the heart and kidneys, shared pathways of neurohormonal activation, hypertension, and vascular and interstitial fibrosis implicate the relevance of systemic vascular health. The availability of a long axial field of view positron emission tomography (PET)/computed tomography (CT) system enables simultaneous evaluation of cardiac and renal blood flow.
3739. Defining Demographic-specific Coronary Artery Calcium Percentiles in the Population Aged ≥75: The ARIC Study and MESA.
作者: Frances M Wang.;Miguel Cainzos-Achirica.;Shoshana H Ballew.;Josef Coresh.;Aaron R Folsom.;Candace M Howard.;Wendy S Post.;Lynne E Wagenknecht.;Matthew J Budoff.;Michael J Blaha.;Kunihiro Matsushita.
来源: Circ Cardiovasc Imaging. 2023年16卷9期e015145页
Current clinical guidelines recommend a coronary artery calcium (CAC) score of 100 Agatston Units or demographic-specific 75th percentile as high-risk thresholds for guiding atherosclerotic cardiovascular disease preventive therapy. Meanwhile, low CAC can help derisk individuals who may safely defer statin therapy. However, limited data from the early 2000s, including just 208 older Black individuals, inform CAC percentiles for adults aged 75 to 85 years, and none have been established in adults aged ≥85 years. This study aims to characterize the distribution of CAC and establish demographic-specific CAC percentiles in the population aged ≥75 years.
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