3641. Efficacy and safety of the neonatal Fc receptor inhibitor efgartigimod in adults with primary immune thrombocytopenia (ADVANCE IV): a multicentre, randomised, placebo-controlled, phase 3 trial.
作者: Catherine M Broome.;Vickie McDonald.;Yoshitaka Miyakawa.;Monica Carpenedo.;David J Kuter.;Hanny Al-Samkari.;James B Bussel.;Marie Godar.;Jaume Ayguasanosa.;Kristof De Beuf.;Francesco Rodeghiero.;Marc Michel.;Adrian Newland.; .
来源: Lancet. 2023年402卷10413期1648-1659页
Primary immune thrombocytopenia is an autoimmune disorder mediated partly by platelet autoantibodies, resulting in thrombocytopenia, bleeding, and constitutional symptoms. Efgartigimod, a first-in-class novel human IgG1 Fc fragment, binds the neonatal Fc receptor with high affinity and thus reduces serum IgG concentrations, including autoantibodies. The objective of this study was to evaluate the efficacy and safety of efgartigimod in adults with persistent and chronic primary immune thrombocytopenia.
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