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322. ACTA2 Pathogenic Variants Activating Heat Shock Factor 1 and Increasing Cholesterol Biosynthesis in Smooth Muscle Cells Predispose to Early Onset Atherosclerosis.
作者: Maura L Boerio.;Abhijnan Chattopadhyay.;Xue-Yan Duan.;Aamuktha Karla.;Ernesto Calderon Martinez.;Amelie Pinard.;Andrew K Morse.;Darshan Reddy.;Sree Dharma.;Walter Velasco-Torrez.;Julien Marcadier.;Siddharth K Prakash.;Sherene Shalhub.;Julie De Backer.;Richmond Jeremy.;Shaine A Morris.;Anji T Yetman.;Alan C Braverman.;Dianna M Milewicz.
来源: Circ Genom Precis Med. 2026年19卷1期e005169页
ACTA2 pathogenic variants predispose to thoracic aortic disease, and a subset of variants lead to early onset atherosclerotic cardiovascular disease (ASCVD). The molecular pathway linking misfolded SMA (α-smooth muscle actin) monomers to augmented atherosclerosis-associated smooth muscle cell phenotypic modulation can be modeled in vitro by stably expressing the ACTA2 p.R149C variant in Acta2-/- smooth muscle cells.
323. Fatal Steam Pop Complicating Investigational SESAME Transcatheter Myotomy Using Off-the-Shelf Equipment.
作者: Robert J Lederman.;Adam B Greenbaum.;Rim N Halaby.;Annette M Stine.;Jaffar M Khan.;Christopher G Bruce.;Toby Rogers.;Patrick T Gleason.;Ozlem Bilen.;Vasilis C Babaliaros.
来源: Circ Cardiovasc Interv. 2026年19卷2期e016252页 324. Impact of Restenosis Pattern on the Safety and Efficacy of Paclitaxel-Coated Balloon Versus Uncoated Balloon for Coronary In-Stent Restenosis.
作者: Dany Jacob.;Adam Salisbury.;J Aaron Grantham.;Richard Shlofmitz.;Jeffrey Moses.;William Bachinsky.;Suhail Dohad.;Steven Rudick.;Robert Stoler.;Brian K Jefferson.;William Nicholson.;John Altman.;Rafael Cavalcante.;Ajay J Kirtane.;Robert W Yeh.
来源: Circ Cardiovasc Interv. 2026年19卷2期e016018页 325. Connexin-43 Restoration Alleviates Desmosomal Arrhythmogenic Cardiomyopathy.
作者: Jing Zhang.;Fabian Zanella.;Matthew W Ellis.;William H Bradford.;Erika Joana Gutierrez-Lara.;Tsui-Min Wang.;Kyohei Fujita.;Charlize Duron.;Ioannis Karakikes.;Robert C Lyon.;Valeria Mezzano.;Jason D Roberts.;Cassiano Carromeu.;Yusu Gu.;Jody L Martin.;Alysson R Muotri.;Melvin Scheinman.;Kirk L Peterson.;Farah Sheikh.
来源: Circ Heart Fail. 2026年e013801页
Arrhythmogenic cardiomyopathy (ACM) is a fatal genetic heart disease primarily caused by mutations in desmosomal genes, leading to impaired cell-cell adhesion, ventricular arrhythmias, and progressive heart failure. Although gene therapy for specific ACM populations shows promise, it remains unclear whether mutation-agnostic pathways dysregulated across desmosomal mutations could be exploited for therapeutic intervention in this genetically broad and severe population. The reduction in expression of the ventricular gap junction protein Cx43 (connexin-43) is a common molecular alteration underlying desmosomal junctional deficits and arrhythmias, suggesting a potential common underlying mechanism and a therapeutic target for ACM. We hypothesized that restoration of Cx43 expression could be a mutation-agnostic intervention for ACM.
326. Phenotypic Severity of SCN5A-Related Bradycardia Is Independent of Dominant-Negative and Coupled Gating Effects.
作者: Ayami Tano.;Koichi Kato.;Kohei Yamauchi.;Hideyuki Jinzai.;Takafumi Iguchi.;Futoshi Toyoda.;Yuichi Baba.;Toru Kubo.;Seiko Ohno.;Takeru Makiyama.;Yoshihisa Nakagawa.;Minoru Horie.
来源: Circ Arrhythm Electrophysiol. 2026年19卷2期e014270页
Pathogenic SCN5A variants are associated with inherited arrhythmias such as long-QT syndrome, Brugada syndrome, and sick sinus syndrome. While Nav1.5, an α-subunit of the cardiac sodium channel encoded by SCN5A, has been considered to function as a monomer, recent studies reveal that a reduction of sodium current in wild-type Nav1.5 can be caused by dimerization with loss-of-function mutated Nav1.5 through dominant-negative effects. However, the clinical significance of the dominant-negative effect remains unclear.
327. ECG-Based Prediction of Shock-Refractory Ventricular Fibrillation During Resuscitation Without Interrupting CPR.
作者: Jason Coult.;Julia A King.;Heemun Kwok.;J Nathan Kutz.;Jennifer Blackwood.;Patrick M Boyle.;Cindy H Hsu.;Mohamud R Daya.;Nicholas J Johnson.;Peter J Kudenchuk.;Thomas D Rea.
来源: Circ Arrhythm Electrophysiol. 2026年19卷2期e014558页 328. Arctic Front Advance Versus POLARx Cryoablation System for Pulmonary Vein Isolation in Patients With Atrial Fibrillation: A Single-Center Randomized Controlled Trial.
作者: David Ferreira.;Jovita Dwivedi.;Stephen Brienesse.;Michael M Malaty.;Kerissa Govender.;Natasha Trevaskis.;Byron Hughes.;Aaron L Sverdlov.;Nicholas Collins.;Andrew Boyle.;Gwilym M Morris.;Malcolm Barlow.;Nicholas Jackson.
来源: Circ Arrhythm Electrophysiol. 2026年19卷2期e014446页 329. Association of Statin Discontinuation in Pregnancy With Maternal Cardiovascular Health and Birth Outcomes: A Nationwide Cohort Study.
作者: Yongtai Cho.;Danbee Kang.;HyunJoo Lim.;Hyesung Lee.;Eun-Young Choi.;Ju-Young Shin.;Ki Hong Choi.
来源: Circulation. 2026年153卷7期504-515页
Discontinuing statin therapy before pregnancy remains challenging, especially in high-risk women. We evaluated the risks of maternal cardiovascular, gestational, and fetal outcomes associated with continuing versus discontinuing statin therapy before the last menstrual period (LMP).
334. Multipopulation Genome-Wide Association Study Identifies Novel Loci for Bicuspid Aortic Valve and Reveals Shared Genetic Architecture With Aortopathies.
作者: Francisca Bermudez.;Gabrielle Shakt.;Annie Bowles.;Patrick Alba.;Tia Dinatale.;Kyong Mi Chang.;Philip S Tsao.;Julie Lynch.;Daniel Dochtermann.;Saiju Pyarajan.;Aeron Small.;Michael G Levin.;Scott M Damrauer.
来源: Circ Genom Precis Med. 2026年19卷1期e005491页 335. Association Between the 2022 AHA/ACC/HFSA Heart Failure Staging and Cardiovascular and Kidney Outcomes in Patients With Diabetes and Kidney Disease: A Post Hoc Analysis of the SCORED Randomized Controlled Trial.
作者: Ayodele Odutayo.;Deepak L Bhatt.;Vikas S Sridhar.;Michael Szarek.;Christopher P Cannon.;Lawrence A Leiter.;Darren K McGuire.;Julia B Lewis.;Renato D Lopes.;Benjamin M Scirica.;Kausik K Ray.;Michael J Davies.;Phillip Banks.;Manon Girard.;Subodh Verma.;Jacob A Udell.;Bertram Pitt.;Ph Gabriel Steg.;David Z I Cherney.
来源: Circ Heart Fail. 2026年19卷3期e013054页
The 2022 American Heart Association/American College of Cardiology/Heart Failure Society of America heart failure (HF) classification incorporates cardiac biomarkers to identify early risk of HF. The HF stages may also guide the prognosis and management of cardiovascular and kidney-related events.
336. Proteomics Profiling Reveals Circulating Biomarkers and Dysregulated Pathways in Transthyretin Amyloid Cardiomyopathy.
作者: Ree Lu.;Ani Nalbandian.;Keitaro Akita.;Sergio Teruya.;Dimitrios Bampatsias.;Alfonsina Mirabal Santos.;Mathew S Maurer.;Yuichi J Shimada.
来源: Circ Heart Fail. 2026年19卷2期e013220页
Transthyretin amyloid cardiomyopathy (ATTR-CM) causes a restrictive cardiomyopathy resulting in heart failure (HF). Signaling pathways associated with ATTR-CM are not well defined. The purpose of this study was to identify signaling pathways that are dysregulated in ATTR-CM compared with controls.
337. Proteomic Signatures of Cardiac Dysfunction Among People With Diabetes: The Atherosclerosis Risk in Communities Study.
作者: Justin B Echouffo-Tcheugui.;Chiadi E Ndumele.;Jingsha Chen.;Mary R Rooney.;Keenan A Walker.;Pascal Schlosser.;Kuni Matsushita.;Morgan E Grams.;Christie C Ballantyne.;Ron C Hoogeveen.;Eric Boerwinkle.;Bing Yu.;Amil M Shah.;Ruth F Dubin.;Rajat Deo.;Yue Ren.;Jerome I Rotter.;Kent D Taylor.;Wendy S Post.;Peter Ganz.;Elizabeth Selvin.;Josef Coresh.
来源: Circ Heart Fail. 2026年19卷3期e013171页
To investigate the proteomic signatures of heart failure (HF) in diabetes. The underlying mechanisms of the elevated risk of HF in diabetes are unknown.
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