Overlap in routine laboratory profiles complicates differential diagnosis of rheumatic diseases, particularly seronegative spondyloarthritis. We examined whether models trained on routine labs reproduce diagnostic assignment patterns and yield calibrated, explainable probabilities.

Genetic predisposition increases the risk of gout, while walking activity may reduce it. We evaluated whether genetic predisposition modifies the association between walking activity and gout risk.

To evaluate sex-based differences in clinical presentation, vascular phenotype, diagnostic approaches, treatment, adverse events and outcomes among patients with giant cell arteritis (GCA).

Polyarteritis nodosa (PAN) is a rare necrotizing vasculitis occurring alone or associated with other conditions, including VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome and chronic myelomonocytic leukaemia (CMML). We aimed to compare the presentation and outcomes of VEXAS- or CMML-associated PAN (VEXAS-PAN and CMML-PAN) with those of primary PAN.

Fibromyalgia (FM) is a complex, chronic syndrome characterized by widespread musculoskeletal pain and cognitive difficulties. Occupational and psychosocial stressors may contribute to the development and exacerbation of FM symptoms. This cross-sectional study was conducted to determine the prevalence of FM symptoms and associated factors among students and faculty at Umm Al Qura University in Saudi Arabia.

(1) Update data on work participation among patients with SSc followed in a multidisciplinary setting at a Belgian reference centre; (2) Investigate associations between work outcomes, personal, disease-related and contextual factors.

Osteoarthritis (OA) is the most prevalent chronic musculoskeletal disease. Early identification of individuals at risk of knee structural progression is essential for targeted interventions. This study aimed to develop and validate a machine/deep learning (ML/DL)-based prognostic model for knee OA progression using serum metabolomics.

Sjögren’s disease (SjD) is a multifaceted, systemic autoimmune disease with substantial clinical heterogeneity. The objective of this study was to conduct a qualitative expert opinion exercise to explore how SjD is assessed, evaluated and managed in international clinical practice.

Glucocorticoid pulse therapy is commonly prescribed by rheumatologists worldwide for a wide variety of serious and potentially life-threatening diseases. Pulse therapy also has the potential to lower the cumulative glucocorticoid burden, which has already been proven in systemic lupus erythematosus and giant cell arteritis. The standard practice in rheumatology is to administer this therapy intravenously, but current literature suggests that oral methylprednisolone is a non-inferior option for clinical outcomes and safety. Integrating oral methylprednisolone pulse therapy into rheumatological practice might have considerable benefits, not only for patients but also for society as a whole. In this Viewpoint, we provide a review of oral methylprednisolone pulse therapy covering pharmacology, safety, patient preference, sustainability, and its possible use in rheumatology practice. We aim to increase awareness among rheumatologists of the potential use of oral glucocorticoid pulse therapy as this modest change in clinical practice has major benefits.

Cerebral small vessel disease (CSVD) imposes a significant burden on patients with systemic lupus erythematosus (SLE) and adversely impacts their health.