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3081. Clinical Guideline for Preimplantation Genetic Testing in Inherited Cardiac Diseases.
作者: Job A J Verdonschot.;Debby M E I Hellebrekers.;Vanessa P M van Empel.;Malou Heijligers.;Sonja de Munnik.;Edith Coonen.;Jos C M F Dreesen.;Arthur van den Wijngaard.;Han G Brunner.;Masoud Zamani Esteki.;Stephane R B Heymans.;Christine E M de Die-Smulders.;Aimée D C Paulussen.
来源: Circ Genom Precis Med. 2024年17卷2期e004416页
Preimplantation genetic testing (PGT) is a reproductive technology that selects embryos without (familial) genetic variants. PGT has been applied in inherited cardiac disease and is included in the latest American Heart Association/American College of Cardiology guidelines. However, guidelines selecting eligible couples who will have the strongest risk reduction most from PGT are lacking. We developed an objective decision model to select eligibility for PGT and compared its results with those from a multidisciplinary team.
3082. Two Facets of Shear Stress Post Drug Coating Balloon: Angiography Versus Optical Coherence Tomography Fusion Approach.
作者: Eric K W Poon.;Kai Ninomiya.;Shigetaka Kageyama.;Xiaojing Guo.;Bernhard Reimers.;Ryo Torii.;Jouke Dijkstra.;Christos V Bourantas.;Johan H C Reiber.;Peter Barlis.;Yoshinobu Onuma.;Patrick W Serruys.
来源: Circ Cardiovasc Imaging. 2024年17卷4期e016279页 3083. Atrial Septal Defect, Pulmonary Arterial Hypertension, and Diastolic Left Heart Failure: When 3 Players Come into the Game.
作者: Tobias Rutz.;John-David Aubert.;Maurice Beghetti.;Eric Eeckhout.;Olivier Muller.;Judith Bouchardy.;Patrick Yerly.
来源: Circ Heart Fail. 2024年17卷5期e010545页 3084. Reproductive Carrier Screening: Identifying Families at Risk for Familial Hypercholesterolemia in the United States.
作者: Vivienne Souter.;Emily Becraft.;Samantha Brummitt.;Bryan J Gall.;Brittany Prigmore.;Yang Wang.;Peter Benn.
来源: Circ Genom Precis Med. 2024年17卷2期e004457页
Familial hypercholesterolemia is a treatable genetic condition but remains underdiagnosed. We reviewed the frequency of pathogenic or likely pathogenic (P/LP) variants in the LDLR gene in female individuals receiving reproductive carrier screening.
3085. Regional Variation in Cardiovascular Genes Enables a Tractable Genome Editing Strategy.
作者: Vikki A Krysov.;Rachel H Wilson.;Nicholas S Ten.;Nathan Youlton.;Hannah N De Jong.;Shirley Sutton.;Yong Huang.;Chloe M Reuter.;Megan E Grove.;Matthew T Wheeler.;Euan A Ashley.;Victoria N Parikh.
来源: Circ Genom Precis Med. 2024年17卷2期e004370页
To realize the potential of genome engineering therapeutics, tractable strategies must be identified that balance personalized therapy with the need for off-the-shelf availability. We hypothesized that regional clustering of pathogenic variants can inform the design of rational prime editing therapeutics to treat the majority of genetic cardiovascular diseases with a limited number of reagents.
3086. Virus-Induced Acute Respiratory Distress Syndrome Causes Cardiomyopathy Through Eliciting Inflammatory Responses in the Heart.
作者: Jana Grune.;Geetika Bajpai.;Pervin Tülin Ocak.;Eva Kaufmann.;Kyle Mentkowski.;Steffen Pabel.;Nina Kumowski.;Fadi E Pulous.;Kim A Tran.;David Rohde.;Shuang Zhang.;Yoshiko Iwamoto.;Gregory R Wojtkiewicz.;Claudio Vinegoni.;Ursula Green.;Filip K Swirski.;James R Stone.;Jochen K Lennerz.;Maziar Divangahi.;Maarten Hulsmans.;Matthias Nahrendorf.
来源: Circulation. 2024年150卷1期49-61页
Viral infections can cause acute respiratory distress syndrome (ARDS), systemic inflammation, and secondary cardiovascular complications. Lung macrophage subsets change during ARDS, but the role of heart macrophages in cardiac injury during viral ARDS remains unknown. Here we investigate how immune signals typical for viral ARDS affect cardiac macrophage subsets, cardiovascular health, and systemic inflammation.
3087. PREVENT Equations: A New Era in Cardiovascular Disease Risk Assessment.
作者: Alexander C Razavi.;Payal Kohli.;Darren K McGuire.;Seth S Martin.;Tamar S Polonsky.;John W McEvoy.;Seamus P Whelton.;Roger S Blumenthal.
来源: Circ Cardiovasc Qual Outcomes. 2024年17卷4期e010763页 3090. Diagnostic Performance of Angiography-Derived Quantitative Flow Ratio in Complex Coronary Lesions.
作者: Xianpeng Wu.;Kan Wang.;Guohua Li.;Jie Wu.;Jun Jiang.;Feng Gao.;Lingjun Zhu.;Qiyuan Xu.;Xinhong Wang.;Mengxi Xu.;Hui Chen.;Longhui Ma.;Xianjun Han.;Nan Luo.;Shengxian Tu.;Jian'an Wang.;Xinyang Hu.
来源: Circ Cardiovasc Imaging. 2024年17卷3期e016046页
Quantitative flow ratio derived from computed tomography angiography (CT-QFR) and invasive coronary angiography (Murray law-based quantitative flow ratio [μQFR]) are novel approaches enabling rapid computation of fractional flow reserve without the use of pressure guidewires and vasodilators. However, the feasibility and diagnostic performance of both CT-QFR and μQFR in evaluating complex coronary lesions remain unclear.
3091. Cardiac Magnetic Resonance to Predict Cardiac Mass Malignancy: The CMR Mass Score.
作者: Pasquale Paolisso.;Luca Bergamaschi.;Francesco Angeli.;Marta Belmonte.;Alberto Foà.;Lisa Canton.;Damiano Fedele.;Matteo Armillotta.;Angelo Sansonetti.;Francesca Bodega.;Sara Amicone.;Nicole Suma.;Emanuele Gallinoro.;Domenico Attinà.;Fabio Niro.;Paola Rucci.;Elisa Gherbesi.;Stefano Carugo.;Saima Musthaq.;Andrea Baggiano.;Anna Giulia Pavon.;Marco Guglielmo.;Edoardo Conte.;Daniele Andreini.;Gianluca Pontone.;Luigi Lovato.;Carmine Pizzi.
来源: Circ Cardiovasc Imaging. 2024年17卷3期e016115页
Multimodality imaging is currently suggested for the noninvasive diagnosis of cardiac masses. The identification of cardiac masses' malignant nature is essential to guide proper treatment. We aimed to develop a cardiac magnetic resonance (CMR)-derived model including mass localization, morphology, and tissue characterization to predict malignancy (with histology as gold standard), to compare its accuracy versus the diagnostic echocardiographic mass score, and to evaluate its prognostic ability.
3092. Long-Term Effects of Mavacamten on Electromechanical Dispersion and Deformation in Obstructive Hypertrophic Cardiomyopathy.
作者: Annamaria Del Franco.;Eszter Dalma Palinkas.;Clarissa C A Bellagamba.;Giulia Biagioni.;Mattia Zampieri.;Alberto Marchi.;Iacopo Olivotto.
来源: Circ Heart Fail. 2024年17卷3期e011188页 3094. Response by Amat-Santos et al to Letter Regarding Article, "Laser Coronary Atherectomy and Polymeric Coronary Wires in Uncrossable Lesions: a Word of Caution".
作者: Ignacio J Amat-Santos.;Giorgio Marengo.;Carlos Cortés.;Juan Pablo Sánchez-Luna.;Jose Carlos Gonzalez-Gutiérrez.;Javier Gómez Herrero.;Jorge Sanz-Sanchez.;Hipólito Gutiérrez.;Ana Serrador.;Alberto Campo.;Sara Blasco-Turrión.;Gabriele Gasparini.;J Alberto San Román.
来源: Circ Cardiovasc Interv. 2024年17卷3期e013996页 3095. Redo-TAVR Feasibility After SAPIEN 3 Stratified by Implant Depth and Commissural Alignment: A CT Simulation Study.
作者: Anoop N Koshy.;Gilbert H L Tang.;Sahil Khera.;Manish Vinayak.;Megan Berdan.;Sneha Gudibendi.;Amit Hooda.;Lucy Safi.;Stamatios Lerakis.;George D Dangas.;Samin K Sharma.;Annapoorna S Kini.;Parasuram Krishnamoorthy.
来源: Circ Cardiovasc Interv. 2024年17卷3期e013766页
Redo-transcatheter aortic valve replacement (TAVR) can pin the index transcatheter heart valve leaflets open leading to sinus sequestration and restricting coronary access. The impact of initial implant depth and commissural alignment on redo-TAVR feasibility is unclear. We sought to determine the feasibility of redo-TAVR and coronary access after SAPIEN 3 (S3) TAVR stratified by implant depth and commissural alignment.
3096. Transcatheter Patent Ductus Arteriosus Closure in Premature Infants: A Multicenter Retrospective Study Comparing Available Devices.
作者: Stephen T Dalby.;Kamel Shibbani.;Austin Mercadante.;Surendranath R Veeram Reddy.;Osamah Aldoss.;Brent M Gordon.;Howaida El-Said.;Bassel Mohammad Nijres.
来源: Circ Cardiovasc Interv. 2024年17卷3期e013723页 3097. Letter by Jurado-Román et al Regarding Article, "Laser Coronary Atherectomy and Polymeric Coronary Wires in Uncrossable Lesions: A Word of Caution".
作者: Alfonso Jurado-Román.;Piotr J Wacinski.;Mohaned Egred.; .
来源: Circ Cardiovasc Interv. 2024年17卷3期e013954页 3098. Impact of Incomplete Revascularization After PCI in Left Main Disease: The EXCEL Trial.
作者: Ziad A Ali.;Javier Jas Garcia.;Keyvan Karimi Galougahi.;Jennifer Horst.;Anthony Gallo.;Doosup Shin.;Ori Ben-Yehuda.;Shmuel Chen.;Björn Redfors.;Arie Pieter Kappetein.;Joseph F Sabik.;Patrick W Serruys.;Gregg W Stone.
来源: Circ Cardiovasc Interv. 2024年17卷3期e013192页
The importance of complete revascularization after percutaneous coronary intervention (PCI) in patients with left main coronary artery disease is uncertain. We investigated the clinical impact of complete revascularization in patients with left main coronary artery disease undergoing PCI in the EXCEL trial (Evaluation of XIENCE Versus Coronary Artery Bypass Surgery for Effectiveness of Left Main Revascularization).
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