19. Efficacy, Immunogenicity, and Safety of Modified mRNA Influenza Vaccine.
作者: David Fitz-Patrick.;Donald S McVinnie.;Lisa A Jackson.;Graham Crowther.;Anita Geevarughese.;Kevin D Cannon.;Lazaro M Garcia.;Yanely Pineiro Puebla.;Zhuobiao Yi.;Luke Cunliffe.;Alok Maniar.;Agnieszka M Zareba.;Claudia Ana Ianos.;Emily Gomme.;Kenneth Koury.;Pirada Suphaphiphat Allen.;Annaliesa S Anderson.;Alejandra Gurtman.;Kelly Lindert.; .
来源: N Engl J Med. 2025年393卷20期2001-2011页
Influenza remains a major health burden despite the use of licensed vaccines. Nucleoside-modified messenger RNA (modRNA) influenza vaccines have shown promising immunogenicity against influenza and an acceptable safety profile in a phase 1-2 trial.
20. A Multicomponent Intervention to Improve Maternal Infection Outcomes.
作者: David Lissauer.;Luis Gadama.;Catriona Waitt.;Sonia Whyte.;Girvan Burnside.;Aiswarya Anilkumar.;Regina Makuluni.;Peace Okwaro.;Liu Yang.;Peter Waitt.;Owen Musopole.;Rosemary Bilesi.;Bertha Maseko.;Joel Lwasa.;Richard Mugahi.;Charles Olaro.;Mohammed Lamorde.;Mirriam Makuta.;Chimwemwe Kachiwaya.;Tionge Mkandawire.;Adrian Malunga.;Nyadani Chitsulo.;Prisca Abitimo.;Tabitha Ayabo.;Andrew Weeks.;James Martin.;Karla Hemming.;Ioannis Gallos.;Edward J M Monk.;Jennifer Riches.;Chikondi Chapuma.;Judith Nanyondo S.;Fabiana Lorencatto.;Mark Monahan.;Benedetta Allegranzi.;Catherine Dunlop.;Lou Atkins.;Anna Rosala-Hallas.;Tracy Roberts.;Carrol Gamble.;Address Malata.;Nicola Desmond.;Edward Kommwa.;Abi Merriel.;William Parry-Smith.;Rebecca Smith.;Ivy Ndumu.;Eleanor Williams.;Bob Faque.;Gertrude Banda.;Alinane L Nyondo-Mipando.;Adelline Twimukye.;Tim Chater.;Aristotelis Diplas.;Vanessa Brizuela.;Joao Paulo Souza.;Jamie Rylance.;James Cheshire.;Lydia Hawker.;Arri Coomarasamy.;Mercedes Bonet.
来源: N Engl J Med. 2025年
Maternal infection and sepsis are major causes of maternal death and severe illness worldwide, particularly in low- and middle-income countries. Inconsistent implementation of evidence-based recommendations for infection prevention and management and delays in detection and treatment of maternal sepsis contribute to the number of preventable deaths.
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