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1. Global Effect of Modifiable Risk Factors on Cardiovascular Disease and Mortality.
作者: .;Christina Magnussen.;Francisco M Ojeda.;Darryl P Leong.;Jesus Alegre-Diaz.;Philippe Amouyel.;Larissa Aviles-Santa.;Dirk De Bacquer.;Christie M Ballantyne.;Antonio Bernabé-Ortiz.;Martin Bobak.;Hermann Brenner.;Rodrigo M Carrillo-Larco.;James de Lemos.;Annette Dobson.;Marcus Dörr.;Chiara Donfrancesco.;Wojciech Drygas.;Robin P Dullaart.;Gunnar Engström.;Marco M Ferrario.;Jean Ferrières.;Giovanni de Gaetano.;Uri Goldbourt.;Clicerio Gonzalez.;Guido Grassi.;Allison M Hodge.;Kristian Hveem.;Licia Iacoviello.;M Kamran Ikram.;Vilma Irazola.;Modou Jobe.;Pekka Jousilahti.;Pontiano Kaleebu.;Maryam Kavousi.;Frank Kee.;Davood Khalili.;Wolfgang Koenig.;Anna Kontsevaya.;Kari Kuulasmaa.;Karl J Lackner.;David M Leistner.;Lars Lind.;Allan Linneberg.;Thiess Lorenz.;Magnus Nakrem Lyngbakken.;Reza Malekzadeh.;Sofia Malyutina.;Ellisiv B Mathiesen.;Olle Melander.;Andres Metspalu.;J Jaime Miranda.;Marie Moitry.;Joseph Mugisha.;Mahdi Nalini.;Vijay Nambi.;Toshiharu Ninomiya.;Karen Oppermann.;Eleonora d'Orsi.;Andrzej Pająk.;Luigi Palmieri.;Demosthenes Panagiotakos.;Arokiasamy Perianayagam.;Annette Peters.;Hossein Poustchi.;Andrew M Prentice.;Eva Prescott.;Ulf Risérus.;Veikko Salomaa.;Susana Sans.;Satoko Sakata.;Ben Schöttker.;Aletta E Schutte.;Sadaf G Sepanlou.;Sanjib Kumar Sharma.;Jonathan E Shaw.;Leon A Simons.;Stefan Söderberg.;Abdonas Tamosiunas.;Barbara Thorand.;Hugh Tunstall-Pedoe.;Raphael Twerenbold.;Diego Vanuzzo.;Giovanni Veronesi.;Julia Waibel.;S Goya Wannamethee.;Masafumi Watanabe.;Philipp S Wild.;Yao Yao.;Yi Zeng.;Andreas Ziegler.;Stefan Blankenberg.
来源: N Engl J Med. 2023年389卷14期1273-1285页
Five modifiable risk factors are associated with cardiovascular disease and death from any cause. Studies using individual-level data to evaluate the regional and sex-specific prevalence of the risk factors and their effect on these outcomes are lacking.
2. 20-Year Risks of Breast-Cancer Recurrence after Stopping Endocrine Therapy at 5 Years.
作者: Hongchao Pan.;Richard Gray.;Jeremy Braybrooke.;Christina Davies.;Carolyn Taylor.;Paul McGale.;Richard Peto.;Kathleen I Pritchard.;Jonas Bergh.;Mitch Dowsett.;Daniel F Hayes.; .
来源: N Engl J Med. 2017年377卷19期1836-1846页
The administration of endocrine therapy for 5 years substantially reduces recurrence rates during and after treatment in women with early-stage, estrogen-receptor (ER)-positive breast cancer. Extending such therapy beyond 5 years offers further protection but has additional side effects. Obtaining data on the absolute risk of subsequent distant recurrence if therapy stops at 5 years could help determine whether to extend treatment.
3. Early, Goal-Directed Therapy for Septic Shock - A Patient-Level Meta-Analysis.
作者: .;Kathryn M Rowan.;Derek C Angus.;Michael Bailey.;Amber E Barnato.;Rinaldo Bellomo.;Ruth R Canter.;Timothy J Coats.;Anthony Delaney.;Elizabeth Gimbel.;Richard D Grieve.;David A Harrison.;Alisa M Higgins.;Belinda Howe.;David T Huang.;John A Kellum.;Paul R Mouncey.;Edvin Music.;Sandra L Peake.;Francis Pike.;Michael C Reade.;M Zia Sadique.;Mervyn Singer.;Donald M Yealy.
来源: N Engl J Med. 2017年376卷23期2223-2234页
After a single-center trial and observational studies suggesting that early, goal-directed therapy (EGDT) reduced mortality from septic shock, three multicenter trials (ProCESS, ARISE, and ProMISe) showed no benefit. This meta-analysis of individual patient data from the three recent trials was designed prospectively to improve statistical power and explore heterogeneity of treatment effect of EGDT.
4. Kidney-Failure Risk Projection for the Living Kidney-Donor Candidate.
作者: Morgan E Grams.;Yingying Sang.;Andrew S Levey.;Kunihiro Matsushita.;Shoshana Ballew.;Alex R Chang.;Eric K H Chow.;Bertram L Kasiske.;Csaba P Kovesdy.;Girish N Nadkarni.;Varda Shalev.;Dorry L Segev.;Josef Coresh.;Krista L Lentine.;Amit X Garg.; .
来源: N Engl J Med. 2016年374卷5期411-21页
Evaluation of candidates to serve as living kidney donors relies on screening for individual risk factors for end-stage renal disease (ESRD). To support an empirical approach to donor selection, we developed a tool that simultaneously incorporates multiple health characteristics to estimate a person's probable long-term risk of ESRD if that person does not donate a kidney.
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