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1. High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis: The D-Lay MS Randomized Clinical Trial.
作者: Eric Thouvenot.;David Laplaud.;Christine Lebrun-Frenay.;Nathalie Derache.;Emmanuelle Le Page.;Elisabeth Maillart.;Caroline Froment-Tilikete.;Giovanni Castelnovo.;Olivier Casez.;Marc Coustans.;Anne-Marie Guennoc.;Olivier Heinzlef.;Laurent Magy.;Chantal Nifle.;Xavier Ayrignac.;Agnès Fromont.;Nicolas Gaillard.;Nathalie Caucheteux.;Ivania Patry.;Jérôme De Sèze.;Romain Deschamps.;Pierre Clavelou.;Damien Biotti.;Gilles Edan.;William Camu.;Hanane Agherbi.;Dimitri Renard.;Christophe Demattei.;Pascale Fabbro-Peray.;Thibault Mura.;Manon Rival.; .
来源: JAMA. 2025年333卷16期1413-1422页
Vitamin D deficiency is a risk factor for multiple sclerosis (MS) and is associated with the risk of disease activity, but data on the benefits of supplementation are conflicting.
2. Effects of Combining Coronary Calcium Score With Treatment on Plaque Progression in Familial Coronary Artery Disease: A Randomized Clinical Trial.
作者: Nitesh Nerlekar.;Sheran A Vasanthakumar.;Kristyn Whitmore.;Cheng Hwee Soh.;Jasmine Chan.;Vinay Goel.;Jacqueline Ryan.;Catherine Jones.;Tony Stanton.;Geoffrey Mitchell.;Andrew Tonkin.;Gerald F Watts.;Stephen J Nicholls.;Thomas H Marwick.; .
来源: JAMA. 2025年333卷16期1403-1412页
Coronary artery calcium (CAC) scoring provides prognostic information, especially in patients at intermediate risk for coronary artery disease (CAD). However, the benefit of combining CAC score with a primary prevention strategy has not been tested in a randomized trial.
3. First-Line Sugemalimab Plus Chemotherapy for Advanced Gastric Cancer: The GEMSTONE-303 Randomized Clinical Trial.
作者: Xiaotian Zhang.;Jufeng Wang.;Gang Wang.;Yanqiao Zhang.;Qingxia Fan.;Chuangxin Lu.;Changlu Hu.;Meili Sun.;Yiye Wan.;Sanyuan Sun.;Junye Wang.;Li Zhang.;Yongqian Shu.;Jie Luo.;Dan Zhu.;Zhenwei Shen.;Sheng Yao.;Qingmei Shi.;Jason Yang.;Lin Shen.; .
来源: JAMA. 2025年333卷15期1305-1314页
Gastric cancer, including gastroesophageal junction cancer, is one of the most commonly diagnosed cancers worldwide, with high mortality. Sugemalimab is a fully human anti-programmed death-ligand 1 (PD-L1) antibody. The combination of sugemalimab and chemotherapy showed promising antitumor activity and safety in a phase 1b study among patients with treatment-naive, unresectable, locally advanced or metastatic gastric or gastroesophageal junction adenocarcinoma. This combination was further evaluated in the GEMSTONE-303 phase 3 trial.
4. Evaluation of a Clinical Decision Support System for Imaging Requests: A Cluster Randomized Clinical Trial.
作者: Stijntje W Dijk.;Claudia Wollny.;Joerg Barkhausen.;Olav Jansen.;Peter Mildenberger.;Moritz C Halfmann.;Jonas Stroeder.;Dimitris Rizopoulos.;M G Myriam Hunink.;Thomas Kroencke.
来源: JAMA. 2025年333卷14期1212-1221页
Given the widespread use of medical imaging, evaluating the effectiveness of interventions to improve appropriateness is crucial for optimizing health care resources and patient outcomes.
5. Simvastatin and Rifaximin in Decompensated Cirrhosis: A Randomized Clinical Trial.
作者: Elisa Pose.;César Jiménez.;Giacomo Zaccherini.;Daniela Campion.;Salvatore Piano.;Frank Erhard Uschner.;Koos de Wit.;Olivier Roux.;Kohilan Gananandan.;Wim Laleman.;Cristina Solé.;Sonia Alonso.;Berta Cuyàs.;Xavier Ariza.;Adrià Juanola.;Ann T Ma.;Laura Napoleone.;Jordi Gratacós-Ginès.;Marta Tonon.;Enrico Pompili.;Jordi Sánchez-Delgado.;Andrew S Allegretti.;Manuel Morales-Ruiz.;Marta Carol.;Martina Pérez-Guasch.;Núria Fabrellas.;Judit Pich.;Claudia Martell.;María Joyera.;Gemma Domenech.;José Ríos.;Ferrán Torres.;Miquel Serra-Burriel.;Rubén Hernáez.;Elsa Solà.;Isabel Graupera.;Hugh Watson.;Germán Soriano.;Rafael Bañares.;Rajeshwar P Mookerjee.;Claire Francoz.;Ulrich Beuers.;Jonel Trebicka.;Paolo Angeli.;Carlo Alessandria.;Paolo Caraceni.;Víctor M Vargas.;Juan G Abraldes.;Patrick S Kamath.;Pere Ginès.; .
来源: JAMA. 2025年333卷10期864-874页
There are no useful treatments to prevent the development of severe complications of liver cirrhosis. Simvastatin and rifaximin have shown beneficial effects in liver cirrhosis.
6. Palliative Care Program for Community-Dwelling Individuals With Dementia and Caregivers: The IN-PEACE Randomized Clinical Trial.
作者: Greg A Sachs.;Nina M Johnson.;Sujuan Gao.;Alexia M Torke.;Susan E Hickman.;Amy Pemberton.;Andrea Vrobel.;Minmin Pan.;Jennifer West.;Kurt Kroenke.
来源: JAMA. 2025年333卷11期962-971页
Care management benefits community-dwelling patients with dementia, but studies include few patients with moderate to severe dementia or from racial and ethnic minority populations, lack palliative care, and seldom reduce health care utilization.
7. Health System, Community-Based, or Usual Dementia Care for Persons With Dementia and Caregivers: The D-CARE Randomized Clinical Trial.
作者: David B Reuben.;Thomas M Gill.;Alan Stevens.;Jeff Williamson.;Elena Volpi.;Maya Lichtenstein.;Lee A Jennings.;Rebecca Galloway.;Jenny Summapund.;Katy Araujo.;David Bass.;Lisa Weitzman.;Zaldy S Tan.;Leslie Evertson.;Mia Yang.;Katherine Currie.;Aval-Na'Ree S Green.;Sybila Godoy.;Sitara Abraham.;Jordan Reese.;Rafael Samper-Ternent.;Roxana M Hirst.;Pamela Borek.;Peter Charpentier.;Can Meng.;James Dziura.;Yunshan Xu.;Eleni A Skokos.;Zili He.;Sherry Aiudi.;Peter Peduzzi.;Erich J Greene.; .
来源: JAMA. 2025年333卷11期950-961页
The effectiveness of different approaches to dementia care is unknown.
8. Negative Pressure Dressings to Prevent Surgical Site Infection After Emergency Laparotomy: The SUNRRISE Randomized Clinical Trial.
作者: .;Kristy Atherton.;James Brown.;Hamish Clouston.;Pete Coe.;Rui Duarte.;Nagendra N Dudi-Venkata.;Sarah Duff.;Natasha Egoroff.;Rebecca Fish.;James Glasbey.;Natalie Ives.;Manjinder Kaur.;Laura Magill.;Samir Mehta.;Thomas Pinkney.;Peter Pockney.;Toby Richards.;Tarik Sammour.;Hema Sekhar.;Yash Sinha.;Martyn Stott.;Richard Wilkin.
来源: JAMA. 2025年333卷10期853-863页
Patients undergoing unplanned abdominal surgical procedures are at increased risk of surgical site infection (SSI). It is not known if incisional negative pressure wound therapy (iNPWT) can reduce SSI rates in this setting.
9. Transanal vs Laparoscopic Total Mesorectal Excision and 3-Year Disease-Free Survival in Rectal Cancer: The TaLaR Randomized Clinical Trial.
作者: Ziwei Zeng.;Shuangling Luo.;Hong Zhang.;Miao Wu.;Dan Ma.;Quan Wang.;Ming Xie.;Qing Xu.;Jun Ouyang.;Yi Xiao.;Yongchun Song.;Bo Feng.;Qingwen Xu.;Yanan Wang.;Yi Zhang.;Lishuo Shi.;Li Ling.;Xingwei Zhang.;Liang Huang.;Zuli Yang.;Junsheng Peng.;Xiaojian Wu.;Donglin Ren.;Meijin Huang.;Ping Lan.;Jianping Wang.;Weidong Tong.;Mingyang Ren.;Huashan Liu.;Liang Kang.; .
来源: JAMA. 2025年333卷9期774-783页
Previous studies have demonstrated the advantages of short-term histopathological outcomes and complications associated with transanal total mesorectal excision (TME) compared with laparoscopic TME. However, the long-term oncological outcomes of transanal TME remain ambiguous. This study aims to compare 3-year disease-free survival of transanal TME with laparoscopic TME.
10. Palliative Care Initiated in the Emergency Department: A Cluster Randomized Clinical Trial.
作者: Corita R Grudzen.;Nina Siman.;Allison M Cuthel.;Oluwaseun Adeyemi.;Rebecca Liddicoat Yamarik.;Keith S Goldfeld.; .;Benjamin S Abella.;Fernanda Bellolio.;Sorayah Bourenane.;Abraham A Brody.;Lauren Cameron-Comasco.;Joshua Chodosh.;Julie J Cooper.;Ashley L Deutsch.;Marie Carmelle Elie.;Ahmed Elsayem.;Rosemarie Fernandez.;Jessica Fleischer-Black.;Mauren Gang.;Nicholas Genes.;Rebecca Goett.;Heather Heaton.;Jacob Hill.;Leora Horwitz.;Eric Isaacs.;Karen Jubanyik.;Sangeeta Lamba.;Katharine Lawrence.;Michelle Lin.;Caitlin Loprinzi-Brauer.;Troy Madsen.;Joseph Miller.;Ada Modrek.;Ronny Otero.;Kei Ouchi.;Christopher Richardson.;Lynne D Richardson.;Matthew Ryan.;Elizabeth Schoenfeld.;Matthew Shaw.;Ashley Shreves.;Lauren T Southerland.;Audrey Tan.;Julie Uspal.;Arvind Venkat.;Laura Walker.;Ian Wittman.;Erin Zimny.
来源: JAMA. 2025年333卷7期599-608页
The emergency department (ED) offers an opportunity to initiate palliative care for older adults with serious, life-limiting illness.
11. Intra-Arterial Tenecteplase Following Endovascular Reperfusion for Large Vessel Occlusion Acute Ischemic Stroke: The POST-TNK Randomized Clinical Trial.
作者: Jiacheng Huang.;Jie Yang.;Chang Liu.;Linyu Li.;Dahong Yang.;Changwei Guo.;Guoyong Zeng.;Jiaxing Song.;Jinfu Ma.;Xu Xu.;Xiaolei Shi.;Shihai Yang.;Wenzhe Sun.;Zhixi Wang.;Yufeng Tang.;Maojun Jiang.;Li Wang.;Xiangping Cheng.;Jun Luo.;Peiyang Zhou.;Xing Fang.;Guangsen Cheng.;Zhongfan Ruan.;Jinglun Li.;Jincheng Liu.;Bo Lei.;Yaoyu Tian.;Xiaolin Tan.;Guangxiong Yuan.;Jian Wang.;Xinyuan Huang.;Shengling Deng.;Zhenglong Jin.;Xin Zou.;Jie Zhang.;Daoyou Cheng.;Xiaojun Luo.;Jiasheng Liao.;Jian Miao.;Zhenqiang Li.;Yaxuan Sun.;Guohui Jiang.;Deyan Kong.;Shuyu Jiang.;Zhiyuan Wang.;Duolao Wang.;Johannes Kaesmacher.;Thanh N Nguyen.;Raul G Nogueira.;Jeffrey L Saver.;Yangmei Chen.;Wenjie Zi.; .
来源: JAMA. 2025年333卷7期579-588页
The impact of adjunctive intra-arterial tenecteplase administration following near-complete to complete reperfusion by endovascular thrombectomy (EVT) for acute ischemic stroke is unknown.
12. Intra-Arterial Urokinase After Endovascular Reperfusion for Acute Ischemic Stroke: The POST-UK Randomized Clinical Trial.
作者: Chang Liu.;Changwei Guo.;Fengli Li.;Nizhen Yu.;Jiacheng Huang.;Zhouzhou Peng.;Weilin Kong.;Jiaxing Song.;Xiang Liu.;Shitao Fan.;Chengsong Yue.;Boyu Chen.;Chong Zheng.;Xingyun Yuan.;Jian Sheng.;Youlin Wu.;Bo Sun.;Zengqiang Zhao.;Minzhen Zhu.;Ling Han.;Qiang Shi.;Zhongbin Xia.;Xianjin Shang.;Fengguang Li.;Rongzong Li.;Feixue Yue.;Shunfu Jiang.;Dengwen Song.;Min Song.;Yuanjun Shan.;Chawen Ding.;Li Yao.;Yong Yang.;Junbin Chen.;Wencheng He.;Feibao Pan.;Wensheng Zhang.;Tieying Cai.;Shibo Han.;Wei Li.;Gongbo Li.;Chen Gong.;Liping Huang.;Cheng Huang.;Duolao Wang.;Johannes Kaesmacher.;Thanh N Nguyen.;Raul G Nogueira.;Jeffrey L Saver.;Wenjie Zi.;Yangmei Chen.;Qingwu Yang.; .
来源: JAMA. 2025年333卷7期589-598页
Persisting or new thrombi in the distal arteries and the microcirculation have been reported to limit the benefits of successful endovascular thrombectomy for patients with acute ischemic stroke. It remains uncertain whether intra-arterial thrombolysis by urokinase following near-complete to complete reperfusion by thrombectomy improves outcomes among patients with ischemic stroke due to large vessel occlusion.
13. Oral Glucose-Lowering Agents vs Insulin for Gestational Diabetes: A Randomized Clinical Trial.
作者: Doortje Rademaker.;Leon de Wit.;Ruben G Duijnhoven.;Daphne N Voormolen.;Ben Willem Mol.;Arie Franx.;J Hans DeVries.;Rebecca C Painter.;Bas B van Rijn.; .;Sarah E Siegelaar.;Bettina M C Akerboom.;Rosalie M Kiewiet-Kemper.;Marion A L Verwij-Didden.;Fahima Assouiki.;Simone M Kuppens.;Mirjam M Oosterwerff.;Eva Stekkinger.;Mattheus J M Diekman.;Tatjana E Vogelvang.;Gerdien Belle-van Meerkerk.;Sander Galjaard.;Koen Verdonk.;Annemiek Lub.;Tamira K Klooker.;Ineke Krabbendam.;Jeroen P H van Wijk.;Anjoke J M Huisjes.;Thomas van Bemmel.;Remco G W Nijman.;Annewieke W van den Beld.;Wietske Hermes.;Solrun Johannsson-Vidarsdottir.;Anneke G Vlug.;Remke C Dullemond.;Henrique J Jansen.;Marieke Sueters.;Eelco J P de Koning.;Judith O E H van Laar.;Pleun Wouters-van Poppel.;Inge M Evers.;Marina E Sanson-van Praag.;Eline S van den Akker.;Catherine B Brouwer.;Brenda B Hermsen.;Ralph Scholten.;Rick I Meijer.;Marsha van Leeuwen.;Johanna A M Wijbenga.;Lia D E Wijnberger.;Arianne C van Bon.;Flip W van der Made.;Silvia A Eskes.;Mirjam Zandstra.;William H van Houtum.;Babette A M Braams-Lisman.;Catharina R G M Daemen-Gubbels.;Janna W Nijkamp.;Harold W de Valk.;Maurice G A J Wouters.;Richard G IJzerman.;Irwin Reiss.;Joris A M van der Post.;Judith E Bosmans.
来源: JAMA. 2025年333卷6期470-478页
Metformin and glyburide monotherapy are used as alternatives to insulin in managing gestational diabetes. Whether a sequential strategy of these oral agents results in noninferior perinatal outcomes compared with insulin alone is unknown.
14. Camrelizumab vs Placebo in Combination With Chemotherapy as Neoadjuvant Treatment in Patients With Early or Locally Advanced Triple-Negative Breast Cancer: The CamRelief Randomized Clinical Trial.
作者: Li Chen.;Hui Li.;Hao Zhang.;Huawei Yang.;Jun Qian.;Zhihua Li.;Yu Ren.;Shu Wang.;Peifen Fu.;Hongjian Yang.;Yunjiang Liu.;Jing Sun.;Jianyun Nie.;Ruiwen Lei.;Yongzhong Yao.;Anqin Zhang.;Shouman Wang.;Xiaopeng Ma.;Zhong Ouyang.;Hongwei Yang.;Song-Yang Wu.;Shuo-Wen Cao.;Kun Wang.;Aimei Jiang.;Quchang Ouyang.;Da Pang.;Limin Wei.;Xiaoming Zha.;Yu Shen.;Xiangwen Qu.;Fei Wu.;Xiaoyu Zhu.;Zhonghua Wang.;Lei Fan.;Zhi-Ming Shao.
来源: JAMA. 2025年333卷8期673-681页
Preferred neoadjuvant strategies for early or locally advanced triple-negative breast cancer include a 4-drug chemotherapy regimen containing anthracyclines, cyclophosphamide, taxanes, and platinum. Blockade of the programmed death receptor 1/ligand-1 (PD-1/PD-L1) pathway may improve efficacy of classic neoadjuvant chemotherapy. Camrelizumab, an anti-PD-1 antibody, has showed antitumor activity in advanced triple-negative breast cancer.
15. Active Monitoring With or Without Endocrine Therapy for Low-Risk Ductal Carcinoma In Situ: The COMET Randomized Clinical Trial.
作者: E Shelley Hwang.;Terry Hyslop.;Thomas Lynch.;Marc D Ryser.;Anna Weiss.;Anna Wolf.;Kelsey Norris.;Meredith Witten.;Lars Grimm.;Stuart Schnitt.;Sunil Badve.;Rachel Factor.;Elizabeth Frank.;Deborah Collyar.;Desiree Basila.;Donna Pinto.;Mark A Watson.;Robert West.;Louise Davies.;Jenny L Donovan.;Ayako Shimada.;Yutong Li.;Yan Li.;Antonia V Bennett.;Shoshana Rosenberg.;Jeffrey Marks.;Eric Winer.;Marc Boisvert.;Armando Giuliano.;Kelsey E Larson.;Kathleen Yost.;Priscilla F McAuliffe.;Amy Krie.;Nina Tamirisa.;Lisa A Carey.;Alastair M Thompson.;Ann H Partridge.; .
来源: JAMA. 2025年333卷11期972-980页
Active monitoring for low-risk ductal carcinoma in situ (DCIS) of the breast has been proposed as an alternative to guideline-concordant care, but the safety of this approach is unknown.
16. Early Restrictive vs Liberal Oxygen for Trauma Patients: The TRAUMOX2 Randomized Clinical Trial.
作者: Tobias Arleth.;Josefine Baekgaard.;Volkert Siersma.;Andreas Creutzburg.;Felicia Dinesen.;Oscar Rosenkrantz.;Johan Heiberg.;Dan Isbye.;Søren Mikkelsen.;Peter M Hansen.;Stine T Zwisler.;Søren Darling.;Louise B Petersen.;Maria C R Mørkeberg.;Mikkel Andersen.;Christian Fenger-Eriksen.;Peder T Bach.;Mark G Van Vledder.;Esther M M Van Lieshout.;Niki A Ottenhof.;Iscander M Maissan.;Dennis Den Hartog.;Wolf E Hautz.;Dominik A Jakob.;Manuela Iten.;Matthias Haenggi.;Roland Albrecht.;Jochen Hinkelbein.;Markus Klimek.;Lars S Rasmussen.;Jacob Steinmetz.; .
来源: JAMA. 2025年333卷6期479-489页
Early administration of supplemental oxygen for all severely injured trauma patients is recommended, but liberal oxygen treatment has been associated with increased risk of death and respiratory complications.
17. Electronic Sepsis Screening Among Patients Admitted to Hospital Wards: A Stepped-Wedge Cluster Randomized Trial.
作者: Yaseen M Arabi.;Abdulmohsen Alsaawi.;Mohammed Alzahrani.;Ali M Al Khathaami.;Raed H AlHazme.;Abdullah Al Mutrafy.;Ali Al Qarni.;Ramesh Kumar Vishwakarma.;Rasha Al Anazi.;Eman Al Qasim.;Sheryl Ann Abdukahil.;Fawaz K Al-Rabeah.;Huda Al Ghamdi.;Abdulaleem Alatassi.;Hasan M Al-Dorzi.;Fahad Al-Hameed.;Razan Babakr.;Abdulaziz A Alghamdi.;Salih Bin Salih.;Ahmad Alharbi.;Mufareh Edah AlKatheri.;Hani Mustafa.;Saad Al-Qahtani.;Shaher Al Qahtani.;Nahar Alselaim.;Nabiha Tashkandi.;Ali H Alyami.;Zeyad Alyousef.;Omar AlDibasi.;Abdul Hadi Al-Qahtani.;Abdulaziz Aldawood.;Angela Caswell.;Nouf Al Ayadhi.;Hadeel Al Rehaili.;Ahmed Al Arfaj.;Hatami Al Mubarak.;Turki Alwasaidi.;Saleh Zahrani.;Yousef Alalawi.;Abdulrahman Alhadab.;Tariq Nasser.;Tagwa Omer.;Sameera M Al Johani.;Abdulaziz Alajlan.;Musharaf Sadat.;Mohammed Alzunitan.;Saad Al Mohrij.; .
来源: JAMA. 2025年333卷9期763-773页
Sepsis screening is recommended among hospitalized patients but is supported by limited evidence of effectiveness.
18. High-Flow Nasal Oxygen vs Noninvasive Ventilation in Patients With Acute Respiratory Failure: The RENOVATE Randomized Clinical Trial.
作者: .;Israel S Maia.;Letícia Kawano-Dourado.;Lucas Tramujas.;Neymar Elias de Oliveira.;Rafael Naoki Souza.;Dhaisi Faustino Signorini.;Mariangela Pimentel Pincelli.;Cássio Luis Zandonai.;Regiane Tamires Blasius.;Fabrício Freires.;Vanessa Marques Ferreira.;Marcelo Luz Pereira Romano.;Mieko Claudia Miura.;Caroline Maschio de Censo.;Eliana Bernadete Caser.;Betania Silva.;Daniela Correia Santos Bonomo.;Jussara Alencar Arraes.;Meton Soares de Alencar Filho.;Jacques Gabriel Álvares Horta.;Déborah Campos Oliveira.;Emerson Boschi.;Rafael Lessa Costa.;Glauco Adrieno Westphal.;Juliano Ramos.;Fábio Holanda Lacerda.;Conrado Roberto Hoffmann Filho.;Bruno Valle Pinheiro.;Leonardo Bugarin de Andrade Neumamm.;Mário Roberto Rezende Guimarães Júnior.;Davi Tamamaru de Souza.;Juliana Carvalho Ferreira.;Louis Nakayama Ohe.;Daniel Almeida Schettini.;Marlus Muri Thompson.;Maria Cristina França de Oliveira.;Viviane Cordeiro Veiga.;Karina L Negrelli.;Renato H N Santos.;Lucas Damiani.;Rodrigo M Gurgel.;Samara P C Gomes.;Lucas M Lima.;Tamiris A Miranda.;Ligia N Laranjeira.;Pedro Gabriel Melo de Barros E Silva.;Flávia R Machado.;Mark Fitzgerald.;Anna Bosse.;Joe Marion.;Carlos Roberto Ribeiro Carvalho.;Laurent Brochard.;Roger J Lewis.;Alexandre Biasi Cavalcanti.
来源: JAMA. 2025年333卷10期875-890页
High-flow nasal oxygen (HFNO) and noninvasive ventilation (NIV) are commonly used respiratory support therapies for patients with acute respiratory failure (ARF).
19. Biomarker-Guided Antibiotic Duration for Hospitalized Patients With Suspected Sepsis: The ADAPT-Sepsis Randomized Clinical Trial.
作者: Paul Dark.;Anower Hossain.;Daniel F McAuley.;David Brealey.;Gordon Carlson.;Jonathan C Clayton.;Timothy W Felton.;Belinder K Ghuman.;Anthony C Gordon.;Thomas P Hellyer.;Nazir I Lone.;Uzma Manazar.;Gillian Richards.;Iain J McCullagh.;Ronan McMullan.;James J McNamee.;Hannah C McNeil.;Paul R Mouncey.;Micheal J Naisbitt.;Robert J Parker.;Ruth L Poole.;Anthony J Rostron.;Mervyn Singer.;Matt D Stevenson.;Tim S Walsh.;Ingeborg D Welters.;Tony Whitehouse.;Simon Whiteley.;Peter Wilson.;Keith K Young.;Gavin D Perkins.;Ranjit Lall.; .
来源: JAMA. 2025年333卷8期682-693页
For hospitalized critically ill adults with suspected sepsis, procalcitonin (PCT) and C-reactive protein (CRP) monitoring protocols can guide the duration of antibiotic therapy, but the evidence of the effect and safety of these protocols remains uncertain.
20. Personalized Patient Data and Behavioral Nudges to Improve Adherence to Chronic Cardiovascular Medications: A Randomized Pragmatic Trial.
作者: P Michael Ho.;Thomas J Glorioso.;Larry A Allen.;Richard Blankenhorn.;Russell E Glasgow.;Gary K Grunwald.;Amber Khanna.;David J Magid.;Joel C Marrs.;Sylvie Novins-Montague.;Steven Orlando.;Pamela Peterson.;Mary E Plomondon.;Lisa M Sandy.;Joseph J Saseen.;Katy E Trinkley.;Shawni Vaughn.;Joy Waughtal.;Sheana Bull.
来源: JAMA. 2025年333卷1期49-59页
Poor medication adherence is common. Text messaging is increasingly used to change patient behavior but often not rigorously tested.
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