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164. Study on the diagnostic value of lipid and systemic inflammatory markers in colorectal adenomatous polyps and the construction of a diagnostic model.
Colorectal adenomatous polyps are well-recognized precancerous lesions of colorectal cancer. Early identification and clinial intervention are crucial for reducing the risk of colorectal cancer. This study aimed to systematically investigate the diagnostic value of lipid and systemic inflammatory markers in colorectal adenomatous polyps and to construct a predictive diagnostic model, thereby providing assistance for early clinical identification.
165. Prevalence, anatomic-pathologic findings, and associated factors of nontraumatic ileal perforations among patients with gut perforation: a multicenter cross-sectional study.
作者: Musa Abbas Waziri.;Akello Vivian.;Atwine Raymond.;Amagara Kyomukama Lauben.;Wandabwa Joel.;Musinguzi Edwin.;Awio John Peter.;Nyenke Basara Godfroy.;Kiyaka Sonye.;Fabrice Molle.;Franck Katembo Sikakulya.;Joshua Muhumuza.;Stephen Mbae Kithinji.;ByaMungu Pahari Kagenderezo.;Bienfait Mumbere Vahwere.
来源: BMC Gastroenterol. 2026年
Nontraumatic ileal perforation is a cause of obscure peritonitis characterized by severe toxicity and high mortality. This burden is disproportionately greater in LMICs due to poor hygiene practices, burden of HIV infection, and other comorbidities. This study aimed at determining the prevalence, anatomic-pathologic findings, and factors associated with nontraumatic ileal perforation a multicenter cross‑sectional study at 3 selected hospitals in Uganda.
166. Gastrointestinal bleeding in patients on venoarterial extracorporeal membrane oxygenation: a multicenter observational study.
作者: Zhongman Zhang.;Yi Zhu.;Gang Zhang.;XiaoDong You.;Yanbin Dong.;Deliang Hu.;Haijun Sun.;Wei Li.;Xufeng Chen.
来源: BMC Gastroenterol. 2026年26卷1期
Gastrointestinal (GI) bleeding is a common complication in patients treated with venoarterial extracorporeal membrane oxygenation (VA ECMO), yet comprehensive data on its epidemiology, clinical correlates, and prognostic implications remain inadequately characterized.
167. Knowledge, attitudes, and practices toward bowel preparation for sedation-assisted colonoscopy among patients with digestive disorders: a structural equation modeling analysis.
This study aims to assess the knowledge, attitudes, and practices (KAP) regarding bowel preparation prior to sedation-assisted colonoscopy among patients with digestive disorders.
168. Tumor mitochondrial respiration rather than glycolytic activity predicts recurrence in colorectal cancer: an ex vivo bioenergetic profiling study.
作者: Wei-En Hou.;Chun-Wei Chen.;Yu-De Chu.;Yang-Hsiang Lin.;Jy-Ming Chiang.;Siew-Na Lim.;Wey-Ran Lin.
来源: BMC Gastroenterol. 2026年
Metabolic reprogramming is a recognized hallmark of colorectal cancer (CRC), yet whether intratumoral bioenergetic capacity directly influences clinical outcomes remains unclear. In particular, the relative prognostic contributions of mitochondrial respiration and glycolytic activity to postoperative recurrence have not been systematically evaluated. This study aimed to determine whether tumor oxygen consumption rate (OCR) or extracellular acidification rate (ECAR), measured ex vivo by Seahorse bioenergetic assays, is associated with recurrence-free survival (RFS) and overall survival (OS) in patients with resected CRC.
169. Predisposing factors and histopathological changes in duodenogastric reflux: a retrospective case-control study.
作者: Ümit Karabulut.;Ramazan Yolaçan.;Berat Ebik.;Ahmet Yavuz.;Mustafa Zanyar Akkuzu.;Ferhat Bacaksiz.;Çiğdem Budak Ece.;Feyzullah Uçmak.
来源: BMC Gastroenterol. 2026年
Duodenogastric reflux (DGR), defined as the retrograde flow of duodenal contents into the stomach, has an incompletely understood pathophysiology. This study aimed to evaluate the relationship between DGR and clinical, endoscopic, histopathological, and laboratory parameters in dyspeptic patients, and to assess its association with Helicobacter pylori (H. pylori) infection, intestinal metaplasia, and potential risk factors.
170. Causal effects of cholelithiasis on hepatopancreatobiliary diseases: a multi-cohort Mendelian randomization study.
作者: Jiawei An.;Xue Li.;Yangsuolang Fu.;Huien Xie.;Kai Gao.;Fuhao Zeng.;Yao Wang.;Mingyan Zhu.;Yicheng Xiong.
来源: BMC Gastroenterol. 2026年
Cholelithiasis is commonly associated with multiple hepatopancreatobiliary diseases, yet whether these relationships reflect causal mechanisms or shared risk factors remains unclear.
171. Prognostic value of the systemic immune-inflammation index in gastrointestinal cancers treated with immune checkpoint inhibitors: a systematic review and meta-analysis.
Gastrointestinal (GI) cancers, including pancreatic, gastric, esophageal, colorectal, and hepatocellular carcinoma (HCC), have high mortality rates. Despite advances in immune checkpoint inhibitors (ICIs), treatment outcomes remain variable. Identifying reliable biomarkers, such as the systemic immune-inflammation index (SII), which combines platelet, neutrophil, and lymphocyte counts, could help optimize treatment strategies. Biologically, an elevated SII is thought to indicate a dominance of pro-tumor inflammation and a suppressed adaptive immune response, thereby potentially dampening the therapeutic efficacy of ICIs.
172. Efficacy of abdominal drainage in perforated appendicitis: a retrospective single-center study using AAST grading and inverse probability treatment weighting analysis.
作者: Chengzhi Wang.;Shikuan Li.;Hao Lu.;Hairui Liu.;Zongping Yu.;Shengqiang Wang.;Dawei Zhang.
来源: BMC Gastroenterol. 2026年
While routine use of abdominal drainage in cases of perforated appendicitis is not generally recommended, there exists a paucity of evidence regarding the detailed stratification of its necessity based on varying degrees of intraoperatively detected abdominal contamination. This study aimed to assess the relationship between abdominal drainage and postoperative outcomes in patients with perforated appendicitis, categorized according to AAST severity grades.
173. Prognostic nutritional index as a predictor of ursodeoxycholic acid response in primary biliary cholangitis: a retrospective study.
作者: Mengyao Zheng.;Hongtao Lei.;Haiyu He.;Yaqin Huang.;Huiling Zhu.;Huiying Lin.;Wen Fu.;Wenlin Tai.;Yan Wang.;Jinhui Yang.
来源: BMC Gastroenterol. 2026年
Primary Biliary Cholangitis (PBC) is an autoimmune hepatic disorder characterized by the progressive destruction of intrahepatic bile ducts. Ursodeoxycholic acid (UDCA) remains the primary treatment modality; however, a subset of patients exhibits non-responsiveness to UDCA therapy. The objective of this study is to investigate the association between the Prognostic Nutritional Index (PNI) and UDCA treatment non-responsiveness in individuals diagnosed with PBC.
174. Association of IL-10 promoter and IL-12 gene polymorphisms with the risk of symptomatic Helicobacter pylori infection.
作者: Pezhman Karami.;Sama Mokari.;Mohammad Yousef Alikhani.;Sima Kazemi.;Mina Mirzaei.;Alireza Soltanian.;Mohammad Ahmadyousefi.;Fereshteh Dehdar.;Alireza Rastgoo Haghi.;Ebrahim Azizi.
来源: BMC Gastroenterol. 2026年
The host's immune response to Helicobacter pylori (H. pylori) infection is largely determined by its cytokine profile. Genetic variations within crucial immunomodulatory genes, including those for interleukin-10 (IL-10) and interleukin-12 (IL-12), are thought to influence an individual's vulnerability to the infection and its clinical consequences by modifying cytokine production. Nonetheless, research data derived from diverse human populations continue to show inconsistent results.
175. Association between total body water and the risk of gastrointestinal symptoms: evidence from NHANES and Mendelian randomization analyses.
Total body water (TBW) is an important indicator of fluid homeostasis and is closely related to various metabolic and chronic diseases. However, the relationship between TBW and gastrointestinal symptoms (stomach or intestinal illness, SII) remains unclear. Most previous studies were observational and lacked causal inference. This study, based on data from the National Health and Nutrition Examination Survey (NHANES, 2001-2018) and combined with two-sample Mendelian randomization (MR), explored the nonlinear relationship and potential causal association between TBW and gastrointestinal symptoms from both epidemiological and genetic perspectives.
176. Endoscopic incision and debridement for presumed delayed postoperative anastomotic submucosal abscess of the rectum: a case report.
作者: Hai-Hua Zhou.;Jian-Ping Xu.;Shuai Yuan.;Ya-Mei Ma.;Sheng-Li Shi.;Wei Zhang.;Rui-Qiang Li.
来源: BMC Gastroenterol. 2026年
Anastomotic lesions after colorectal cancer surgery are uncommon and usually signify tumor recurrence or early complications. Delayed submucosal abscess occurring several years after curative resection is extremely rare. Due to the lack of specific clinical manifestations, imaging studies may mimic tumors or other subepithelial lesions, making the diagnosis challenging. Moreover, such lesions are located deep within the intestinal wall at the anastomotic site, which further complicates their management. Herein, we report a rare case of presumed delayed postoperative anastomotic submucosal abscess of the rectum successfully treated by endoscopic incision and debridement, highlighting diagnostic pitfalls and therapeutic feasibility.
177. Comparison of proton vs. photon radiotherapy for liver cancer: a meta-analysis.
To systematically evaluate the efficacy and safety of proton beam radiotherapy (PBT) compared with photon radiotherapy in the treatment of hepatocellular carcinoma (HCC), thereby providing evidence-based guidance for clinical decision-making in radiotherapy modality selection.
178. Epithelial FOXP3 Orchestrates O-Glycosylated IL6 Secretion to Drive Pancreatic Fibrocarcinogenesis.
作者: Ruining Gong.;Junjin Wang.;Minghan Ren.;Wenqing Zhang.;Shuai Ping.;Yaoyao Jing.;Ke Lei.;Qian Yu.;Leina Ma.;Chao Gao.;Chenyang Zhao.;Shunli Fu.;Yihai Xing.;Jing Xue.;Jigang Wang.;Hao Sun.;Jinsuo Chen.;Shugang Zhang.;Mingyang Liu.;Tiansuo Zhao.;Ashok Saluja.;Zhan Yang.;He Ren.
来源: Gastroenterology. 2026年
Pancreatic fibrosis characterizes pancreatic ductal adenocarcinoma, driving therapeutic resistance and organ failure. However, the mechanisms initiating fibrosis during early preneoplastic stages remain unclear. We investigated the role of the transcription factor FOXP3, unexpectedly identified within the epithelial cells of precancerous lesions.
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