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141. Epidemiologic transition of biliary tract cancers in an endemic region of Korea: insights from a regional cancer center cohort.
Biliary tract cancers (BTCs) in East Asia have traditionally been linked to inflammation-related etiologies. However, metabolic risk factors are increasingly contributing to BTC development. Temporal trends in BTC epidemiology remain underexplored in the Korean population. This study aimed to review 13-year trends in BTCs, focusing on metabolic and inflammatory comorbidities, in a southeastern Korean cancer center historically characterized by a high incidence of inflammation-related BTCs.
143. Comparison of the efficacy of transarterial chemoembolization combined with radiofrequency ablation or sintilimab and bevacizumab for unresectable hepatocellular carcinoma.145. Creatinine-to-body weight ratio as an independent predictor of hepatic steatosis severity in metabolic dysfunction-associated steatotic liver disease: a cross-sectional study.
作者: Xiaoning Sun.;Xiaozhong Wang.;Ayesha Younas.;Shuanghu Wang.;Muhammad Sohail.;Jiaojian Lv.;Zuxiu Huang.;Yunxiao Liu.
来源: BMC Gastroenterol. 2026年 146. Long-term clinical outcomes of gastric mucosa-associated lymphoid tissue lymphoma: a retrospective study in regions with a high prevalence of Helicobacter pylori infection.
作者: Jin Won Kim.;Dong-Han Yeom.;Seon-Young Park.;Seung-Young Seo.;Hye-Su You.;Ga-Ram You.;Byung-Chul Jin.;Jung-In Lee.;Young-Dae Kim.;Suck-Chei Choi.;Wan-Sik Lee.;Sung Sun Kim.
来源: BMC Gastroenterol. 2026年 148. Gastrointestinal bleeding risk in cirrhotic portal vein thrombosis: focus on thrombus extension to superior mesenteric vein.
作者: Sa Lv.;Hui Feng.;Tianjiao Xu.;Hua Tian.;Haibo Wang.;Dongze Li.;Shaoli You.;Bing Zhu.
来源: BMC Gastroenterol. 2026年
Portal vein thrombosis (PVT) is a prevalent cirrhosis complication linked to gastrointestinal bleeding. This study aims to assess correlations between PVT classification and the risk of bleeding in patients with cirrhotic PVT.
149. Explainable machine learning predicts mortality in critically ill patients with nonvariceal upper gastrointestinal bleeding: a MIMIC-IV study with external validation.
作者: Jialin Lu.;Chuting Yu.;Hangbang Li.;Qiuxin Li.;Ye Gao.;Wei Wang.;Luowei Wang.
来源: BMC Gastroenterol. 2026年 154. Targeting APE1-Redox Function Reverses SOX9-mediated Chemoresistance in Esophageal Adenocarcinoma.
作者: Heng Lu.;Farah Ballout.;Lei Chen.;Dunfa Peng.;Zheng Chen.;Mohammed Soutto.;Longlong Cao.;Krishnapriya Thangaretnam.;Ravindran Caspa Gokulan.;Timothy C Wang.;Jianwen Que.;Silvia Giordano.;Mary Kay Washington.;Xi Steven Chen.;Xiaodian Sun.;Yuguang Ban.;Oliver Gene McDonald.;Alexander Zaika.;Wael El-Rifai.
来源: Gastroenterology. 2026年
Gastroesophageal reflux disease is the leading risk factor for esophageal adenocarcinoma (EAC), a malignancy that exhibits marked resistance to chemotherapy and results in poor clinical outcomes. This study aims to define and overcome the mechanisms underlying chemoresistance in EAC to enable the development of novel therapeutic strategies.
155. From Gut Feeling to Gray Matter: Mapping Defecation Urgency in Irritable Bowel Syndrome.
作者: Nawroz Barazanji.;Jenny Sjödahl.;Gustav Orell.;Myria Evripidou.;Mary Adjeiwaah.;Adriane Icenhour.;Peter Lundberg.;Susanna Walter.
来源: Gastroenterology. 2026年
Defecation urgency is a common and highly distressing symptom in patients with irritable bowel syndrome (IBS), but its definition remains insufficiently clear. We aimed to compare different measures of urgency, real-life and rectal sensation thresholds, their clinical and neural correlates.
159. Acinar Metaplastic Cells Generate Semi-Homogeneous Niches and Interact With Immune Cells.
作者: Sebastian Arcila-Barrera.;Oshri Yosefov-Levi.;Yehuda Shovman.;Yi Sun.;Cheng-Yi Chen.;Jiang He.;Lior Lubek.;Benjamin Glaser.;Sharona Tornovsky-Babeay.;Karine A Atlan.;Oren Parnas.
来源: Gastroenterology. 2026年
Metaplasia is the first stage in cell transformation that can lead to malignancy. Acinar metaplastic cells form premalignant lesions that have the potential to become invasive and develop into a deadly pancreatic ductal adenocarcinoma. We and others previously showed that acinar metaplastic cells are heterogeneous and include 7 distinct subtypes. The distribution of metaplastic cell types across lesions, their interactions with one another, and their crosstalk with stromal and immune cells remain largely unknown.
160. Activation of the Integrin αV-YAP-CTGF Axis in Liver Sinusoidal Endothelial Cells Promotes Liver Fibrogenesis, Leading to Portal Hypertension and Liver Carcinogenesis in Congestive Hepatopathy.
作者: Seiya Kato.;Hayato Hikita.;Osamu Tsukamoto.;Katsuhiko Sato.;Kohei Kamizono.;Yoichi Sasaki.;Kenji Fukumoto.;Yuta Myojin.;Kazuhiro Murai.;Yuki Tahata.;Yuki Makino.;Yoshinobu Saito.;Takahiro Kodama.;Daisuke Motooka.;Shogo Kobayashi.;Hideki Yokoi.;Masashi Mukoyama.;Yoshiaki Kubota.;Tomohide Tatsumi.;Hidetoshi Eguchi.;Tetsuo Takehara.
来源: Gastroenterology. 2026年
Chronic liver congestion progresses to liver fibrosis, eventually leading to cirrhosis and cancer. This study aimed to elucidate the mechanism of congestive hepatopathy (CH), focusing on liver sinusoidal endothelial cells (LSECs).
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