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104. Safety, Efficacy, and Immunogenicity of a Salmonella Paratyphi A Vaccine.
作者: Naina McCann.;Margarete Paganotti Vicentine.;Narges Ebrahimi.;Melanie Greenland.;Brian Angus.;Andrea M Collins.;Thomas Darton.;Katherine Emary.;Saul N Faust.;Amy Flaxman.;Noshi Maria.;Christopher A Green.;Claudia Juarez Molina.;Ravindra Paidisetti.;Rajeka Lazarus.;Grace C Macaulay.;Florence McLean.;V Krishna Mohan.;M Gangadhara Naidu.;Maheshi N Ramasamy.;D Yogeswara Rao.;Nisha Singh.;Sophie Vernon.;Young Chan Kim.;Myron M Levine.;Xinxue Liu.;Andrew J Pollard.; .
来源: N Engl J Med. 2025年393卷17期1704-1714页
Salmonella enterica serovar Paratyphi A (also known as S. Paratyphi A) is responsible for more than 2 million cases of enteric fever annually. There are no licensed vaccines against S. Paratyphi A.
105. A Randomized Trial of Physical Therapy for Meniscal Tear and Knee Pain.
作者: Jeffrey N Katz.;Jamie E Collins.;Leslie Bisson.;Morgan H Jones.;James J Irrgang.;Faith Selzer.;Clare E Safran-Norton.;Kurt P Spindler.;Heidi Y Yang.;Swastina Shrestha.;Kim L Bennell.;James K Sullivan.;Melissa A Kluczynski.;Kaetlyn Arant.;Maame Opare-Addo.;Jamie L Huizinga.;Zoe Zimmerman.;Derek Sople.;Peter Tonsoline.;Madhuri Kale.;William M Wind.;Antonia F Chen.;Michael Freitas.;Bryson Lesniak.;Kelly Jordan.;Elizabeth G Matzkin.;Courtney Dawson.;Lutul Farrow.;Volker Musahl.;John J Leddy.;Scott D Martin.;Elena Losina.
来源: N Engl J Med. 2025年393卷17期1694-1703页
Physical therapy is routinely recommended for knee pain attributed to a degenerative meniscal tear, but its efficacy has not been established.
106. European Study of Prostate Cancer Screening - 23-Year Follow-up.
作者: Monique J Roobol.;Ivo I de Vos.;Marianne Månsson.;Rebecka A Godtman.;Kirsi M Talala.;Elly den Hond.;Vera Nelen.;Arnauld Villers.;Gregoire Poinas.;Maciej Kwiatkowski.;Stephen Wyler.;Franz Recker.;Donella Puliti.;Giuseppe Gorini.;Marco Zappa.;Alvaro Paez.;Marcos Lujan.;Chris H Bangma.;Teuvo Tammela.;Fritz H Schröder.;Sebastiaan Remmers.;Jonas Hugosson.;Anssi Auvinen.; .
来源: N Engl J Med. 2025年393卷17期1669-1680页
The European Randomized Study of Screening for Prostate Cancer (ERSPC) was initiated in 1993 to assess the effect of prostate-specific antigen (PSA) testing on prostate cancer mortality. Because deaths from prostate cancer are expected to rise worldwide owing to increased life expectancy and population growth, a final analysis of the long-term outcomes of prostate cancer screening is essential to understanding the benefits and harms of PSA testing.
107. Trastuzumab Deruxtecan plus Pertuzumab for HER2-Positive Metastatic Breast Cancer.
作者: Sara M Tolaney.;Zefei Jiang.;Qingyuan Zhang.;Romualdo Barroso-Sousa.;Yeon Hee Park.;Mothaffar F Rimawi.;Cristina Saura.;Andreas Schneeweiss.;Masakazu Toi.;Yee Soo Chae.;Yasemin Kemal.;Mukesh Chaudhari.;Mehmet A N Şendur.;Toshinari Yamashita.;Monica Casalnuovo.;Michael A Danso.;Jie Liu.;Jagdish Shetty.;Pia Herbolsheimer.;Sibylle Loibl.; .
来源: N Engl J Med. 2025年
Trastuzumab deruxtecan has shown efficacy in patients with previously treated human epidermal growth factor receptor 2 (HER2)-positive advanced or metastatic breast cancer. The efficacy and safety of trastuzumab deruxtecan in patients with no previous therapy for HER2-positive advanced or metastatic breast cancer are unclear.
108. Updated Evidence for Covid-19, RSV, and Influenza Vaccines for 2025-2026.
作者: Jake Scott.;Michael S Abers.;Harleen K Marwah.;Nicole C McCann.;Eric A Meyerowitz.;Aaron Richterman.;Derek F Fleming.;Elise J Holmes.;Leah E Moat.;Sydney G Redepenning.;Emily A Smith.;Clare J Stoddart.;Maria E Sundaram.;Angela K Ulrich.;Christopher Alba.;Cory J Anderson.;Meredith K Arpey.;Ethan Borre.;Joseph Ladines-Lim.;Angela J Mehr.;Katherine Rich.;Corey Watts.;Nicole E Basta.;Jana Jarolimova.;Rochelle P Walensky.;Caitlin M Dugdale.
来源: N Engl J Med. 2025年
Changes in the vaccine advisory process in the United States have disrupted immunization guidance, which reinforces the need for independent evidence review to inform decisions regarding immunization for respiratory viruses during the 2025-2026 season.
110. A Pragmatic Trial of Glucocorticoids for Community-Acquired Pneumonia.
作者: Ruth K Lucinde.;Henry Gathuri.;Paul Mwaniki.;Benedict Orindi.;Edwin O Otieno.;Stella Mwakio.;Lillian Mulemi.;Lynda Isaaka.;Jimmy Shangala.;Metrine Saisi.;Elizabeth Isinde.;Irene N Oginga.;Alvin W Wachira.;Evans Manuthu.;Hazel Kariuki.;Patrick Asaava.;Jared Nyikuli.;Cyprian Wekesa.;Amos Otedo.;Hannah Bosire.;Steve B Okoth.;Winston Ongalo.;David M Mukabi.;Wilberforce Lusamba.;Beatrice Muthui.;Isaac Adembesa.;Caroline Mithi.;Mohammed Sood.;Nadia A Aliyan.;Bernard Gituma.;Matiko G Matiko.;Charles A Omondi.;Loice A Ombajo.;Nicholas Kirui.;Lucy Ochola.;Abdirahman I Abdi.;Eunice W Kagucia.;Mike English.;Mainga Hamaluba.;Isabella Ochola-Oyier.;Dorcas Kamuya.;Philip Bejon.;Edwine Barasa.;Ambrose Agweyu.;Samuel Akech.;Anthony O Etyang.
来源: N Engl J Med. 2025年
Adjunctive glucocorticoids may reduce mortality among patients with severe community-acquired pneumonia (CAP) in well-resourced settings. Whether these drugs are beneficial in low-resource settings with limited diagnostic and treatment facilities is unclear.
112. Deferring Arterial Catheterization in Critically Ill Patients with Shock.
作者: Grégoire Muller.;Damien Contou.;Stephan Ehrmann.;Maëlle Martin.;Pascal Andreu.;Toufik Kamel.;Florence Boissier.;Marie-Ange Azais.;Alexandra Monnier.;Sylvie Vimeux.;Amélie Chenal.;Mai-Anh Nay.;Charlotte Salmon Gandonnière.;Jean-Baptiste Lascarrou.;Jean-Baptiste Roudaut.;Gaëtan Plantefève.;Bruno Giraudeau.;Karim Lakhal.;Elsa Tavernier.;Thierry Boulain.; .
来源: N Engl J Med. 2025年393卷19期1875-1888页
In patients with shock, whether noninvasive blood-pressure monitoring is an effective alternative to the recommended use of an arterial catheter is uncertain.
114. Selective Decontamination of the Digestive Tract during Ventilation in the ICU.
作者: .;Brian H Cuthbertson.;Laurent Billot.;Marion K Campbell.;Nick Daneman.;Joshua S Davis.;Anthony Delaney.;Anthony Devaux.;Niall D Ferguson.;Simon R Finfer.;Robert Fowler.;Anthony C Gordon.;Naomi E Hammond.;Gail Klein.;Qiang Li.;John Marshall.;Sharon Micallef.;Srinivas Murthy.;Jayanthi Mysore.;Chinmayi Naik.;Chandni Patel.;Ruxandra Pinto.;Louise Rose.;Ian M Seppelt.;Balasubramanian Venkatesh.;Paul J Young.;John A Myburgh.
来源: N Engl J Med. 2025年
Whether selective decontamination of the digestive tract (SDD) reduces mortality among patients undergoing mechanical ventilation and whether it adversely affects microbial ecology in the intensive care unit (ICU) remain unclear. In an earlier analysis of data from Australia, SDD did not result in a lower incidence of in-hospital death than standard care, but data from the full international trial are needed.
115. Immediate or Deferred Nonculprit-Lesion PCI in Myocardial Infarction.
作者: Robin Nijveldt.;Michael Maeng.;Casper W H Beijnink.;Jan J Piek.;Rasha K Al-Lamee.;Luís Raposo.;Sergio Bravo Baptista.;Javier Escaned.;Justin Davies.;Igor Klem.;Bahram Yosofi.;Robert-Jan M van Geuns.;Christian A Frederiksen.;Lars Jakobsen.;Abdelilah El Barzouhi.;Dirk J van der Heijden.;Mustafa Ilhan.;Saman Rasoul.;Stijn Brinckman.;Colette Saraber.;Daniel A Jones.;Steffen E Petersen.;Tomaž Podlesnikar.;Matjaž Bunc.;Marcel A M Beijk.;Lieuwe H Piers.;Johannes B van Rees.;Henry Seligman.;Graham Cole.;Juan F Iglesias.;Sophie Degrauwe.;Arnoud W J van 't Hof.;Erik Lipsic.;Gabija Pundziute-do Prado.;Pairoj Chattranukulchai.;José F Rodríguez-Palomares.;Johannes Rigger.;Martijn Meuwissen.;Lennaert Kleijn.;Bruno Pereira.;Lorenzo Monti.;René J van der Schaaf.;Juan Sanchis.;Guido Belli.;Jan G P Tijssen.;Troels Thim.;Niels van Royen.; .
来源: N Engl J Med. 2025年
The preferred timing of treatment of nonculprit lesions in patients with ST-segment elevation myocardial infarction (STEMI) remains uncertain. A comparison of immediate percutaneous coronary intervention (PCI) guided by instantaneous wave-free ratio (iFR) and deferred PCI guided by cardiac stress magnetic resonance imaging (MRI) in patients with STEMI and multivessel disease is warranted.
116. Transcatheter or Surgical Aortic-Valve Replacement in Low-Risk Patients at 7 Years.
作者: Martin B Leon.;Michael J Mack.;Philippe Pibarot.;Rebecca T Hahn.;Vinod H Thourani.;S H Kodali.;Philippe Généreux.;Samir R Kapadia.;David J Cohen.;Stuart J Pocock.;Yiran Zhang.;Molly Szerlip.;Julien Ternacle.;S Chris Malaisrie.;Howard C Herrmann.;Wilson Y Szeto.;Mark J Russo.;Vasilis Babaliaros.;Tamim Nazif.;John G Webb.;Raj R Makkar.; .
来源: N Engl J Med. 2025年
Five-year data from the PARTNER 3 trial showed that among low-risk patients with severe, symptomatic aortic stenosis, outcomes were similar among patients who had undergone transcatheter aortic-valve replacement (TAVR) and those who had undergone surgical aortic-valve replacement. Longer-term assessments of clinical outcomes and valve durability are needed.
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