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1127. Epidemiological and clinical features of mpox during the clade Ib outbreak in South Kivu, Democratic Republic of the Congo: a prospective cohort study.
作者: Isabel Brosius.;Emmanuel Hasivirwe Vakaniaki.;Guy Mukari.;Papy Munganga.;Jean Claude Tshomba.;Elise De Vos.;Eugene Bangwen.;Yves Mujula.;Achilleas Tsoumanis.;Christophe Van Dijck.;Aimé Alengo.;Léandre Mutimbwa-Mambo.;Franklin Mweshi Kumbana.;Jenestin Babingwa Munga.;Divin Mazambi Mambo.;James Wakilongo Zangilwa.;Steeven Bilembo Kitwanda.;Sarah Houben.;Nicole A Hoff.;Jean-Claude Makangara-Cigolo.;Eddy Kinganda-Lusamaki.;Martine Peeters.;Anne W Rimoin.;Jason Kindrachuk.;Nicola Low.;Patrick D M C Katoto.;Espoir Bwenge Malembaka.;John H Amuasi.;Olivier Tshiani-Mbaya.;Dally Muamba Kambaji.;Richard Kojan.;Cris Kacita.;Daniel Mukadi-Bamuleka.;Steve Ahuka-Mundeke.;Koen Vercauteren.;Tony Wawina-Bokalanga.;Jean-Jacques Muyembe-Tamfum.;Sabin Sabiti Nundu.;Laurens Liesenborghs.;Placide Mbala-Kingebeni.
来源: Lancet. 2025年405卷10478期547-559页
Clade Ib, a new strain of clade I monkeypox virus, emerged in eastern DR Congo, sparking an international outbreak. Comprehensive studies are needed to assess its transmission dynamics and clinical presentation.
1134. Nivolumab plus ipilimumab versus nivolumab in microsatellite instability-high metastatic colorectal cancer (CheckMate 8HW): a randomised, open-label, phase 3 trial.
作者: Thierry André.;Elena Elez.;Heinz-Josef Lenz.;Lars Henrik Jensen.;Yann Touchefeu.;Eric Van Cutsem.;Rocio Garcia-Carbonero.;David Tougeron.;Guillermo Ariel Mendez.;Michael Schenker.;Christelle de la Fouchardiere.;Maria Luisa Limon.;Takayuki Yoshino.;Jin Li.;Jose Luis Manzano Mozo.;Laetitia Dahan.;Giampaolo Tortora.;Myriam Chalabi.;Eray Goekkurt.;Maria Ignez Braghiroli.;Rohit Joshi.;Timucin Cil.;Francine Aubin.;Elvis Cela.;Tian Chen.;Ming Lei.;Lixian Jin.;Steven I Blum.;Sara Lonardi.
来源: Lancet. 2025年405卷10476期383-395页
CheckMate 8HW prespecified dual primary endpoints, assessed in patients with centrally confirmed microsatellite instability-high or mismatch repair-deficient status: progression-free survival with nivolumab plus ipilimumab compared with chemotherapy as first-line therapy and progression-free survival with nivolumab plus ipilimumab compared with nivolumab alone, regardless of previous systemic treatment for metastatic disease. In our previous report, nivolumab plus ipilimumab showed superior progression-free survival versus chemotherapy in first-line microsatellite instability-high or mismatch repair-deficient metastatic colorectal cancer in the CheckMate 8HW trial. Here, we report results from the prespecified interim analysis for the other primary endpoint of progression-free survival for nivolumab plus ipilimumab versus nivolumab across all treatment lines.
1140. Life expectancy losses in the Gaza Strip during the period October, 2023, to September, 2024.
作者: Michel Guillot.;Mohammed Draidi.;Valeria Cetorelli.;José H C Monteiro Da Silva.;Ismail Lubbad.
来源: Lancet. 2025年405卷10477期478-485页
In the context of the ongoing war in the Gaza Strip, the Gaza Health Ministry (GHM) has reported 45 936 fatalities and more than 10 000 individuals missing or under the rubble for the period Oct 7, 2023, to Jan 8, 2025. The scope of this death count is difficult to fully interpret because it does not account for the size and age distribution of the Gaza Strip population. Moreover, the quality of this death count has been questioned. In this study, we evaluated the quality of the GHM death count by comparing GHM data against register data, and we estimated life expectancy losses in the Gaza Strip for the period October, 2023, to September, 2024, ie, the first 12 months of the war.
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