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82. Fructose drives colorectal cancer progression by regulating crosstalk between cancer-associated fibroblasts and tumour cells.
作者: Yanfen Cui.;Hui Liu.;Laoming Zhang.;He Zhang.;Zhaosong Wang.;Jiefu Wang.;Zhiyong Wang.;Lanlan Song.;Hui Guo.;Liming Liu.;Weijie Song.;Ruifang Niu.;Fei Zhang.
来源: Gut. 2025年
Fructose has been identified as a potential alternative energy source for cancer cells, facilitated by the fructose-specific transporter GLUT5. Elevated GLUT5 expression in cancer cells has been associated with increased tumour aggressiveness. However, the role of fructose in remodelling the tumour microenvironment, particularly in modulating cancer-associated fibroblast (CAF) behaviour, remains underexplored.
85. Disease-associated hepatocytes are predictive of outcomes and survival in MASLD beyond fibrosis staging.
作者: Rodrigo Carlessi.;Timothy James Kendall.;John K Olynyk.;Benjamin J Dwyer.;Michael C Wallace.;Jonathan A Fallowfield.;Janina Ee Tirnitz-Parker.
来源: Gut. 2025年 88. Screening and eradication of Helicobacter pylori for gastric cancer prevention: Taipei Global Consensus II.
作者: Jyh-Ming Liou.;Peter Malfertheiner.;Tzu-Chan Hong.;Hsiu-Chi Cheng.;Kentaro Sugano.;Shailja Shah.;Bor-Shyang Sheu.;Mei-Jyh Chen.;Tsung-Hsien Chiang.;Yi-Chu Chen.;Yoshio Yamaoka.;Sunny H Wong.;Chieh-Chang Chen.;Yeong Yeh Lee.;Duc Trong Quach.;Deng-Chyang Wu.;Ping-I Hsu.;Chun-Ying Wu.;Jeng-Yih Wu.;Jiing-Chyuan Luo.;Wei-Lun Chang.;Hong Lu.;Hidekazu Suzuki.;Hwoon-Yong Jung.;Varocha Mahachai.;Ratha-Korn Vilaichone.;Francis Mégraud.;Jaw-Town Lin.;Khay-Guan Yeoh.;Wai Keung Leung.;Emad M El-Omar.;Yi-Chia Lee.;Ming-Shiang Wu.; .
来源: Gut. 2025年74卷11期1767-1791页
To convene a global consensus on Helicobacter pylori (H pylori) screening and eradication strategies for gastric cancer prevention, identify key knowledge gaps and outline future research directions.
91. Bacteroides intestinalis mediates the sensitivity to irinotecan toxicity via tryptophan catabolites.
作者: Yuanlong Hou.;Hao Wu.;Zhuangyi Zhang.;Jie Wang.;Qifan Chen.;Chunang Lian.;Dandan He.;Ziguang Li.;Wei Wei.;Xin Lin.;Daming Sun.;Baoshan Cao.;Ting Xu.;Mingyuan Cai.;Guangji Wang.;Xueli Zhang.;Liping Duan.;Haiping Hao.;Xiao Zheng.
来源: Gut. 2025年
Late-onset diarrhoea remains a poorly managed concern for clinical irinotecan therapy. Although bacterial β-glucuronidases (β-GUS) mediated SN-38 production is prevailingly thought to mediate intestinal toxicity, β-GUS inhibitors confer limited benefits in the clinic.
93. Pathological tau propagation from the brain to the colon via the vagal efferent pathway in Alzheimer's disease.
作者: Hyunjung Choi.;Seok Beom Hong.;Hui-Wen Liu.;Hyeonggyu Song.;June-Hyun Jeong.;Kyusik Ahn.;SeongJun Kim.;Jaehoon Song.;Jong Won Han.;Dongjoon Lee.;Jinchul Ahn.;Min-Seon Kim.;Seok Chung.;Inhee Mook-Jung.
来源: Gut. 2025年
Alzheimer's disease (AD) is a neurodegenerative disorder marked by the accumulation of amyloid-β (Aβ) plaques and tau neurofibrillary tangles, leading to cognitive decline. Recent research has highlighted the involvement of the gut-brain axis (GBA) in AD progression, suggesting that the disease may also affect the gut.
94. Immunosuppressive contribution of tumour-infiltrating B cells in human intrahepatic cholangiocarcinoma and their role in chemoimmunotherapy outcome.
作者: Giulia Milardi.;Barbara Franceschini.;Chiara Camisaschi.;Simone Puccio.;Guido Costa.;Cristiana Soldani.;Paolo Uva.;Davide Cangelosi.;Roberta Carriero.;Luca Lambroia.;Antonella Cammarota.;Giulio Lodetti-Zangrandi.;Ines Malenica.;Marco Erreni.;Ilaria Montali.;Tiziano Lottini.;Chiara Raggi.;Paolo Kunderfranco.;Michela Anna Polidoro.;Alessio Aghemo.;Rita Balsano.;Tiziana Pressiani.;Salvatore Piscuoglio.;Luca Di Tommaso.;Guido Torzilli.;Lorenza Rimassa.;Enrico Lugli.;Barbara Cassani.;Ana Lleo.
来源: Gut. 2025年
Intrahepatic cholangiocarcinoma (iCCA) is a highly aggressive biliary tract cancer with a poor prognosis and a complex tumour microenvironment (TME) that remains poorly understood.
95. Global consensus statement on the management of pregnancy in inflammatory bowel disease.
作者: Uma Mahadevan.;Cynthia H Seow.;Edward L Barnes.;María Chaparro.;Emma Flanagan.;Sonia Friedman.;Mette Julsgaard.;Sunanda Kane.;Siew Ng.;Joana Torres.;Gillian Watermeyer.;Jesus Yamamoto-Furusho.;Christopher Robinson.;Susan Fisher.;Phil Anderson.;Richard Gearry.;Dana Duricova.;Marla Dubinsky.;Millie Long.; .
来源: Gut. 2025年
Pregnancy can be a complex and risk filled event for women with inflammatory bowel disease (IBD). High-quality studies in this population are lacking, with limited data on medications approved to treat IBD during pregnancy. For patients, limited knowledge surrounding pregnancy impacts pregnancy rates, medication adherence, and outcomes. Limited provider knowledge leads to highly varied practices in care affected by local dogma, available resources, individual interpretation of the literature, and fear of harming the fetus. The variations in guidelines by different societies and countries reflect this and lead to confusion for physicians and patients alike. The Global Consensus Consortium is a group of 39 IBD and content experts and 7 patient advocates from 6 continents who convened to review and assess current data and come to an agreement on best practices based on these data.
97. Outcome of a FODMAP restriction diet with subsequent blinded reintroduction in functional dyspepsia/postprandial distress syndrome.
作者: Karen Van den Houte.;Bert Broeders.;Joran Tóth.;Karen Routhiaux.;Zoë Mariën.;Jasmien Van den Bergh.;Julie Vanderstappen.;Nelle Pauwels.;Ann Meulemans.;Christophe Matthys.;Tim Vanuytsel.;Florencia Carbone.;Jan Tack.
来源: Gut. 2025年
Recent studies have shown increased duodenal mucosal permeability as a possible key player in the pathophysiology of functional dyspepsia (FD). Adverse reaction to nutrients is an important candidate underlying mechanism. Intragastric infusion of fermentable oligo-, di-, monosaccharides and polyols (FODMAPs) induced symptoms reminiscent of FD with a rapid onset.
100. Smoking affects gut immune system of patients with inflammatory bowel diseases by modulating metabolomic profiles and mucosal microbiota.
作者: Eiji Miyauchi.;Takashi Taida.;Kan Uchiyama.;Yumiko Nakanishi.;Tamotsu Kato.;Shigeo Koido.;Nobuo Sasaki.;Toshifumi Ohkusa.;Nobuhiro Sato.;Hiroshi Ohno.
来源: Gut. 2025年
The aetiology and pathogenesis of IBD are intricate, involving genetic and environmental factors. Notably, cigarette smoking has contrasting effects, being detrimental to Crohn's disease (CD) and beneficial to UC. However, the mechanisms underlying these opposite effects remain unclear.
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