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6762. Intradiscal Glucocorticoid Injection for Patients With Chronic Low Back Pain Associated With Active Discopathy: A Randomized Trial.
作者: Christelle Nguyen.;Isabelle Boutron.;Gabriel Baron.;Katherine Sanchez.;Clémence Palazzo.;Raphaël Benchimol.;Guillaume Paris.;Étienne James-Belin.;Marie-Martine Lefèvre-Colau.;Johann Beaudreuil.;Jean-Denis Laredo.;Anne Béra-Louville.;Anne Cotten.;Jean-Luc Drapé.;Antoine Feydy.;Philippe Ravaud.;François Rannou.;Serge Poiraudeau.
来源: Ann Intern Med. 2017年166卷8期547-556页
Active discopathy is associated with a specific phenotype of chronic low back pain (LBP). Local inflammation has a role in active discopathy-associated symptoms.
6763. Oral Direct-Acting Agent Therapy for Hepatitis C Virus Infection: A Systematic Review.
作者: Oluwaseun Falade-Nwulia.;Catalina Suarez-Cuervo.;David R Nelson.;Michael W Fried.;Jodi B Segal.;Mark S Sulkowski.
来源: Ann Intern Med. 2017年166卷9期637-648页
Rapid improvements in hepatitis C virus (HCV) therapy have led to the approval of multiple oral direct-acting antiviral (DAA) regimens by the U.S. Food and Drug Administration (FDA) for treatment of chronic HCV infection.
6764. Clinical Trials of Therapeutics for the Prevention of Congenital Zika Virus Disease: Challenges and Potential Solutions.
作者: Alex P Salam.;Amanda Rojek.;Jake Dunning.;Peter W Horby.
来源: Ann Intern Med. 2017年166卷10期725-732页
Zika virus (ZIKV) infection in pregnancy is associated with adverse fetal outcomes, such as microcephaly and other congenital malformations. No therapeutic options are available to pregnant women with ZIKV infection to prevent these effects. Drug trials in pregnancy raise several scientific, ethical, and logistic challenges, which are compounded further in ZIKV because of limited knowledge of the disease pathophysiology and a product development pipeline in its infancy. We evaluate the major challenges in choosing therapeutics to prevent congenital ZIKV disease and conducting clinical trials of these treatments, with a focus on preventing congenital central nervous system malformations. These challenges must be characterized and planned for now so that clinical trials can progress expediently and effectively in the future.
6766. Survival Comparison of Patients With Cystic Fibrosis in Canada and the United States: A Population-Based Cohort Study.
作者: Anne L Stephenson.;Jenna Sykes.;Sanja Stanojevic.;Bradley S Quon.;Bruce C Marshall.;Kristofer Petren.;Josh Ostrenga.;Aliza K Fink.;Alexander Elbert.;Christopher H Goss.
来源: Ann Intern Med. 2017年166卷8期537-546页
In 2011, the median age of survival of patients with cystic fibrosis reported in the United States was 36.8 years, compared with 48.5 years in Canada. Direct comparison of survival estimates between national registries is challenging because of inherent differences in methodologies used, data processing techniques, and ascertainment bias.
6768. Pharmacologic Therapy for Type 2 Diabetes: Synopsis of the 2017 American Diabetes Association Standards of Medical Care in Diabetes.
作者: James J Chamberlain.;William H Herman.;Sandra Leal.;Andrew S Rhinehart.;Jay H Shubrook.;Neil Skolnik.;Rita Rastogi Kalyani.
来源: Ann Intern Med. 2017年166卷8期572-578页
The American Diabetes Association (ADA) annually updates the Standards of Medical Care in Diabetes to provide clinicians, patients, researchers, payers, and other interested parties with evidence-based recommendations for the diagnosis and management of patients with diabetes.
6769. Cytokine Inhibition in Patients With Chronic Fatigue Syndrome: A Randomized Trial.
作者: Megan E Roerink.;Sebastian J H Bredie.;Michael Heijnen.;Charles A Dinarello.;Hans Knoop.;Jos W M Van der Meer.
来源: Ann Intern Med. 2017年166卷8期557-564页
Interleukin-1 (IL-1), an important proinflammatory cytokine, is suspected to play a role in chronic fatigue syndrome (CFS).
6780. Atrial Fibrillation.
This issue provides a clinical overview of atrial fibrillation, focusing on diagnosis, treatment, and practice improvement. The content of In the Clinic is drawn from the clinical information and education resources of the American College of Physicians (ACP), including MKSAP (Medical Knowledge and Self-Assessment Program). Annals of Internal Medicine editors develop In the Clinic in collaboration with the ACP's Medical Education and Publishing divisions and with the assistance of additional science writers and physician writers.
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