6107. Risk for Arterial and Venous Thrombosis in Patients With Myeloproliferative Neoplasms: A Population-Based Cohort Study.
作者: Malin Hultcrantz.;Magnus Björkholm.;Paul W Dickman.;Ola Landgren.;Åsa R Derolf.;Sigurdur Y Kristinsson.;Therese M L Andersson.
来源: Ann Intern Med. 2018年168卷5期317-325页
Patients with myeloproliferative neoplasms (MPNs) are reported to be at increased risk for thrombotic events. However, no population-based study has estimated this excess risk compared with matched control participants.
6108. White Blood Cell BRCA1 Promoter Methylation Status and Ovarian Cancer Risk.
作者: Per E Lønning.;Elisabet O Berge.;Merete Bjørnslett.;Laura Minsaas.;Ranjan Chrisanthar.;Hildegunn Høberg-Vetti.;Cécile Dulary.;Florence Busato.;Silje Bjørneklett.;Christine Eriksen.;Reidun Kopperud.;Ulrika Axcrona.;Ben Davidson.;Line Bjørge.;Gareth Evans.;Anthony Howell.;Helga B Salvesen.;Imre Janszky.;Kristian Hveem.;Pål R Romundstad.;Lars J Vatten.;Jörg Tost.;Anne Dørum.;Stian Knappskog.
来源: Ann Intern Med. 2018年168卷5期326-334页
The role of normal tissue gene promoter methylation in cancer risk is poorly understood.
6112. Effect of Physical Activity on Frailty: Secondary Analysis of a Randomized Controlled Trial.
作者: Andrea Trombetti.;Mélany Hars.;Fang-Chi Hsu.;Kieran F Reid.;Timothy S Church.;Thomas M Gill.;Abby C King.;Christine K Liu.;Todd M Manini.;Mary M McDermott.;Anne B Newman.;W Jack Rejeski.;Jack M Guralnik.;Marco Pahor.;Roger A Fielding.; .
来源: Ann Intern Med. 2018年168卷5期309-316页
Limited evidence suggests that physical activity may prevent frailty and associated negative outcomes in older adults. Definitive data from large long-term randomized trials are lacking.
6113. Diagnosis of Venous Thromboembolism: 20 Years of Progress.
作者: Philip S Wells.;Ryma Ihaddadene.;Aoife Reilly.;Melissa Anne Forgie.
来源: Ann Intern Med. 2018年168卷2期131-140页
Many guidelines suggest incorporating clinical assessment, imaging, and D-dimer testing into diagnostic algorithms in patients with suspected deep venous thrombosis (DVT) and pulmonary embolism (PE). This special article reviews the evidence supporting the use of algorithms and their individual components for diagnosis of upper- and lower-extremity DVT and PE in adults, including pregnant women. The authors identified evidence through several electronic database searches to April 2017, evaluated the robustness of selected evidence, assessed whether diagnostic approaches that do not use algorithms are acceptable, and identified knowledge gaps that require further research.
6114. Device Closure Versus Medical Therapy Alone for Patent Foramen Ovale in Patients With Cryptogenic Stroke: A Systematic Review and Meta-analysis.
作者: Rahman Shah.;Mannu Nayyar.;Ion S Jovin.;Abdul Rashid.;Beatrix R Bondy.;Tai-Hwang M Fan.;Michael P Flaherty.;Sunil V Rao.
来源: Ann Intern Med. 2018年168卷5期335-342页
The optimal strategy for preventing recurrent stroke in patients with cryptogenic stroke and patent foramen ovale (PFO) is unknown.
6117. Percutaneous Closure Versus Medical Treatment in Stroke Patients With Patent Foramen Ovale: A Systematic Review and Meta-analysis.
作者: Salvatore De Rosa.;Horst Sievert.;Jolanda Sabatino.;Alberto Polimeni.;Sabato Sorrentino.;Ciro Indolfi.
来源: Ann Intern Med. 2018年168卷5期343-350页
New evidence emerged recently regarding the percutaneous closure of patent foramen ovale (PFO) to prevent recurrent stroke in patients with cryptogenic stroke.
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