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581. Fish-Oil Supplementation and Cardiovascular Events in Patients Receiving Hemodialysis.
作者: Charmaine E Lok.;Michael Farkouh.;Brenda R Hemmelgarn.;Louise M Moist.;Kevan R Polkinghorne.;George Tomlinson.;Paul Tam.;Marcello Tonelli.;Jacob A Udell.; .
来源: N Engl J Med. 2026年394卷2期128-137页
Cardiovascular disease is the leading cause of death in patients receiving hemodialysis, yet effective preventive therapies remain limited. Supplementation with n-3 polyunsaturated fatty acids, especially eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), may have cardiovascular benefits in the general population, but efficacy among patients receiving hemodialysis is uncertain.
583. A Phase 3 Trial of Atacicept in Patients with IgA Nephropathy.
作者: Richard Lafayette.;Sean J Barbour.;Robert M Brenner.;Kirk N Campbell.;Tom Doan.;Necmi Eren.;Jürgen Floege.;Vivekanand Jha.;Beom Seok Kim.;Adrian Liew.;Bart Maes.;Atanu Pal.;Roberto Pecoits-Filho.;Richard K S Phoon.;Dana V Rizk.;Hitoshi Suzuki.;Vladimir Tesař.;Hernán Trimarchi.;Xuelian Wei.;Hong Zhang.;Jonathan Barratt.; .
来源: N Engl J Med. 2026年394卷7期647-657页
IgA nephropathy, the most common primary glomerulopathy worldwide, is a kidney disorder of B-cell origin characterized by mesangial accumulation of IgA-containing immune complexes. In at least 50% of patients, IgA nephropathy leads to kidney failure or death within 10 to 20 years after diagnosis. Atacicept is a native human transmembrane activator and calcium-modulator and cyclophilin-ligand interactor (TACI)-Fc fusion protein that inhibits two key immunoregulatory cytokines - B-cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL) - that are thought to be central to the pathophysiology of IgA nephropathy.
591. Cold Perfusion vs. Static Cold Storage of Deceased-Donor Kidneys - at 10 Years.
作者: Rianne Schutter.;Cyril Moers.;Ina Jochmans.;Anja Gallinat.;Andreas Paul.;Jürgen Treckmann.;Jacques Pirenne.;Diethard Monbaliu.;Agita Strelniece.;Ineke Tieken.;Serge Vogelaar.;Axel Rahmel.;Henri G D Leuvenink.;Rutger J Ploeg.; .
来源: N Engl J Med. 2025年393卷18期1859-1861页 598. Safety and Immunogenicity of an rVSV Lassa Fever Vaccine Candidate.
作者: Elissa Malkin.;Marija Zaric.;Mark Kieh.;Lindsey R Baden.;David Fitz-Patrick.;Arianna Marini.;Heejin Yun.;Peter Hayes.;Rachel Bromell.;Morolayo Ayorinde.;Natalia Fernandez.;Ruhani Varma.;Faith Sigei.;Matthew Ward.;Hema Pindolia.;Shayna Sewell.;Fahimah Amini.;Julie Blie.;Barthalomew Wilson.;Patrick Faley.;John McCullough.;Franklin Tokpah.;Cecelia Wisseh.;Elvis Towalid.;Swapnil Hadawale.;Eddy Sayeed.;Devin Hunt.;Nahid Keshavarzi.;Burc Barin.;Irina Maljkovic Berry.;Christopher L Parks.;Shobhna Gopal Truter.;Kathleen Walker.;Johan Vekemans.;Jennifer Lehrman.;Michelle Engelbrecht.;Mariette Malherbe.;Dagna Laufer.;Vincent Philiponis.;Elizabeth Higgs.;Gaudensia Mutua.;Patricia E Fast.;Swati B Gupta.; .
来源: N Engl J Med. 2025年393卷18期1807-1818页
No vaccine is currently available for Lassa fever, a viral hemorrhagic disease that is estimated to cause thousands of deaths each year in western Africa. A replication-competent recombinant vesicular stomatitis virus-vectored vaccine encoding a Lassa virus (LASV) glycoprotein complex, rVSVΔG-LASV-GPC, has been developed, but data on its safety and immunogenicity are limited.
599. Oral Icotrokinra for Plaque Psoriasis in Adults and Adolescents.
作者: Robert Bissonnette.;Jennifer Soung.;Adelaide A Hebert.;Andrew E Pink.;Andreas Pinter.;Angela Y Moore.;Yuling Shi.;Wen-Hui Wang.;Darryl P Toth.;Megan Miller-Kassamali.;Joseph Cafone.;Jingzhi Jiang.;Shu Li.;Cynthia M C DeKlotz.;Fabio Nunes.;Mark G Lebwohl.
来源: N Engl J Med. 2025年393卷18期1784-1795页
Icotrokinra, a targeted oral peptide that selectively binds the interleukin-23 receptor, is under investigation for the treatment of plaque psoriasis.
600. Ten-Year Survival after Postmastectomy Chest-Wall Irradiation in Breast Cancer.
作者: Ian H Kunkler.;Nicola S Russell.;Niall Anderson.;Richard Sainsbury.;J Michael Dixon.;David Cameron.;Juliette Loncaster.;Matthew Hatton.;Helen Westenberg.;Jackie Clarke.;Heather McCarty.;Rhun Evans.;Konstantinos Geropantas.;Virginia Wolstenholme.;Abdulla Alhasso.;Pamela Woodings.;Lisa Barraclough.;Neil Bayman.;Richard Welch.;Fidelis Muturi.;Tracy McEleney.;Jacqueline Burns.;Kathleen Riddle.;Eve Macdonald.;Joanna Dunlop.;Nicole Sergenson.;Geertjan van Tienhoven.;Karen J Taylor.;John M S Bartlett.;Tammy Piper.;Galina Velikova.;Edwin Aird.;Boon Chua.;Coen Hurkmans.;Karen Venables.;Linda J Williams.;Jeremy S Thomas.;Andrew M Hanby.;Marjory Maclennan.;Susan Cleator.;Eldo T Verghese.;Yexiong Li.;Shulian Wang.;Peter Canney.; .; .
来源: N Engl J Med. 2025年393卷18期1771-1783页
The role of postmastectomy chest-wall irradiation in patients with breast cancer classified as pN1 (with involvement of one to three axillary nodes) or pN0 (pathologically node negative) with additional risk factors is uncertain.
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