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41. An Integrative Approach to Lung Cancer Therapy: Linking the TGF-β (+869 C/T) Polymorphism to a Structurally Validated Natural Inhibitor.
作者: Nawar Bahaa Abdulsahib.;Mohammed A Hameed.;Ragheed Hussam Yousif.;Majid Sakhi Jabir.
来源: Asian Pac J Cancer Prev. 2026年27卷4期1421-1428页
This study aimed to create a genetic and clinical roadmap for the TGF-β pathway in an Iraqi population, focusing on the TGF-β1 (+869 C/T) polymorphism.
42. DNA Alterations in the Upstream Region of Exon 1 of OSBPL10 in Northern Thai Patients with Diffuse Large B-Cell Lymphoma.
作者: Phuttirak Yimpak.;Adisak Tantiworawit.;Thanawat Rattanathammethee.;Teerada Daroontum.;Sirinda Aungsuchawan.;Kanokkan Bumroongkit.
来源: Asian Pac J Cancer Prev. 2026年27卷4期1389-1397页
Lymphoma is the most common hematologic malignancy in Thailand, with diffuse large B-cell lymphoma (DLBCL) being the predominant subtype. Early prognostic indicators are essential for guiding clinical decisions. Genetic alterations, particularly in regulatory regions, may serve as potential biomarkers. This study investigated sequence alterations upstream of exon 1 of the OSBPL10 gene and their clinical relevance in a Northern Thai DLBCL population.
43. A Network Meta-Analysis Comparing the Efficacy of Lenvatinib, Atezolizumab plus Bevacizumab, and Sorafenib in the Treatment of Unresectable Hepatocellular Carcinoma.
作者: Ni Putu Sri Indrani Remitha.;I Gede Aswin Parisya Sasmana.;I Komang Wira Ananta Kusuma.;Christo Timothy Mamangdean.;I Gede Putu Supadmanaba.;Dwijo Anargha Sindhughosa.;I Ketut Mariadi.
来源: Asian Pac J Cancer Prev. 2026年27卷4期1377-1388页
Globally, hepatocellular carcinoma (HCC) ranks as the third most common cause of cancer-related death. The five-year overall survival (OS) rate for patients with unresectable HCC is only 12%. Currently, systemic therapies have become the primary treatment options for unresectable hepatocellular carcinoma. Studies comparing the efficacy of first-line treatments including lenvatinib, atezolizumab plus bevacizumab, and sorafenib have shown inconsistent results. There remains a need for updated comparative evidence on cross-mechanism therapy regimens for unresectable disease, as existing findings are still not completely clear. This network meta-analysis aims to provide clearer insights into which treatment offers greater efficacy for patients with unresectable HCC.
44. Protein Expression of MAGEB2 in Normal Oral Mucosa, Oral Epithelial Dysplasia, and Oral Squamous Cell Carcinoma and Its Association with Clinicopathological Parameters.
作者: Noratikah Awang Hasyim.;Sathick Manzoor.;Gou Rean Wong.;Zuraiza Mohamad Zaini.;Rosnah Binti Zain.;Anand Ramanathan.
来源: Asian Pac J Cancer Prev. 2026年27卷4期1359-1367页
To compare the expression of the MAGEB2 antibody in normal oral mucosa (NOM), oral epithelial dysplasia (OED), and oral squamous cell carcinoma (OSCC) patients, and to evaluate the association of MAGEB2 expression with clinicopathological characteristics and overall survival in OSCC patients.
45. Therapeutic Targeting of S100A2 Enhances Chemotherapy Efficacy in vitro in Oral Cancer.
作者: Manish Kumar.;Chandra Prakash Prasad.;Chitrakshi Chopra.;Sonia Thapa.;Shyam Singh Chauhan.
来源: Asian Pac J Cancer Prev. 2026年27卷4期1351-1357页
Despite advancements in multimodal therapies, oral squamous cell carcinoma (OSCC) continues to exhibit poor clinical outcomes, particularly in advanced and recurrent cases. Recent studies have identified the calcium-binding protein S100A2 as a critical mediator of OSCC progression and resistance to therapy. Our prior work demonstrated that cytoplasmic overexpression of S100A2 in oral cancer patients is associated with tumor recurrence and reduced survival. Given its reported role in promoting epithelial-to-mesenchymal transition (EMT), cellular proliferation, and invasiveness, we investigated the in vitro functional impact of S100A2 inhibition in OSCC.
46. Molecular Insights into Identification of Natural AKT1/mTOR Signaling Inhibitors from Veratrum Viride-Derived Alkaloids for Breast Cancer Treatment: A Comprehensive Analysis Using Network Pharmacology, Molecular Docking, and Molecular Dynamics.
作者: Anu Priya Eswaran.;Selvaraj Jayaraman.;Sathan Raj Natarajan.;Vishnu Priya Veeraraghavan.
来源: Asian Pac J Cancer Prev. 2026年27卷4期1335-1350页
Breast cancer (BC) is a complex illness that affects millions of women globally. As its incidence rises, new treatment strategies are needed. Veratrum viride, a traditional medicinal herb, is known for its therapeutic potential, yet its molecular mechanism of action against BC remains unclear. The purpose of this preliminary investigation is to assess V. viride's anti-breast cancer potential by identifying its active compounds and using bioinformatics techniques to clarify their multi-target mechanisms.
47. Tumor Budding Significance as a Biomarker for Clinicopathology and Prognostic Evaluation in Gynecological Malignancy: A Bayesian Meta-Analysis.
作者: I Gede Wikania Wira Wiguna.;Ni Wayan Armerinayanti.;Christo Timothy Mamangdean.;Ngakan Putu Krishna Mahayana.;Putu Mirah Wahyu Subagia Putri.;Kadek Meryndha Kumala Tungga.;Artha Maressa Theodora Simanjuntak.;Frengki Prabowo Saputro Wijayanto.;Suparada Khanaruksombat.;I Gde Sastra Winata.
来源: Asian Pac J Cancer Prev. 2026年27卷4期1323-1334页
Tumor budding (TB) has been recommended as a marker for prognosis and therapeutic decision-making in various types of cancer, yet it has not been comprehensively studied in gynecological malignancies. This study aimed to evaluate the relationship between TB and clinicopathological features, as well as prognosis, in patients with gynecological malignancies, using a Bayesian meta-analysis design.
48. Prediction of Outcomes of Brain Irradiation in Correlation with Molecular Subtypes in Patients with Metastatic Breast Cancer.
作者: Ahmed Sohaib.;Mohamed Alhefny.;Mohamed Taher Amin.;Yostena Mekhail.
来源: Asian Pac J Cancer Prev. 2026年27卷4期1303-1311页
Brain metastases (BM) are a major complication in metastatic breast cancer, especially in HER2-positive and triple-negative subtypes. Despite advances in systemic therapy, BM remains associated with a poor prognosis and often requires radiotherapy. This study evaluates the outcomes of brain irradiation across subtypes and proposes a prognostic scoring system to guide treatment.
49. The Prognostic Impact of Supraclavicular Lymph Node Metastases in Lung Cancer: Do We Need a Modification of the Current Staging System?
作者: Ahmed Sohaib.;Hany F Sedeek.;Mahmoud El Madawie.;Naglaa Said Elabd.;Usama Abouelhassan.;Mohamed Alhefny.
来源: Asian Pac J Cancer Prev. 2026年27卷4期1295-1302页
The management of Stage IIIB non-small-cell lung cancer (NSCLC) is complex. The current staging system does not distinguish between ipsilateral and contralateral supraclavicular lymph node involvement, although this distinction may impact prognosis. This study investigates the differences in prognosis between these two presentations of N3 disease.
50. The Combined Effects of Eleutherine bulbosa Ethanol Extract and Tamoxifen On Cox-2 Levels in a BaLB/c Mouse Breast Cancer Model.
作者: Dian Andriani.;Andi Nilawati Usman.;Risfah Yulianty.;Stang Stang.;Andi Aryandy.
来源: Asian Pac J Cancer Prev. 2026年27卷4期1277-1286页
Chronic inflammation and oxidative stress play important roles in breast cancer progression. Cyclooxygenase-2 (COX-2) is a major proinflammatory enzyme that is often overexpressed in tumor cells. Eleutherine bulbosa (Dayak onion) is a traditional Indonesian medicinal plant with antioxidant and anti-inflammatory properties. This study aimed to evaluate the effect of a combination of ethanol extract of E. bulbosa and tamoxifen on COX-2 levels in a 7,12-dimethylbenz[a]anthracene (DMBA)-induced BALB/c mouse model.
51. In Silico Identification of Hydroxyxanthone Derivatives as CDK2/EGFR Dual Inhibitor for Colorectal Cancer Treatment.
作者: Faris Hermawan.;Anita Dwi Puspitasari.;Lala Adetia Marlina.;Ervan Yudha.;Nela Fatmasari.;Lathifah Puji Hastuti.;Rissa Laila Vifta.
来源: Asian Pac J Cancer Prev. 2026年27卷4期1265-1276页
Both CDK2 (cyclin-dependent kinase 2) and EGFR (epidermal growth factor receptor) play significant roles in the development and progression of colorectal cancer. In vitro studies of several hydroxyxanthone derivatives for the treatment of WiDr cancer cell lines have revealed potential anticancer activity against colorectal cancer. The present study aims to identify hydroxyxanthone derivatives as potential drug candidates for colorectal cancer treatment through an in silico approach.
52. Comparative Performance Evaluation of GCN, GAT, and GraphSAGE Architectures for Drug-Gene Interaction Prediction in Ameloblastoma via MEK-Pathway Targeting.
作者: Nausathkhan Ubayathulla.;M R Muthusekar.;Pradeep Kumar Yadalam.
来源: Asian Pac J Cancer Prev. 2026年27卷4期1257-1264页
A key element of computational drug discovery is the precise prediction of drug-gene interactions, particularly when working with intricate biological systems where relational dependencies are essential. Because biological networks are graph-structured, traditional machine learning techniques frequently fall short. Graph Neural Networks (GNNs) have emerged as a viable approach for learning meaningful representations from this data type in response to this challenge. In this study, three state-of-the-art GNN architectures Graph Convolutional Networks (GCN), Graph Attention Networks (GAT), and GraphSAGE are comprehensively compared using a bipartite graph constructed from drug-target biochemical activity data.
53. The Interplay of PD-L1, Kynurenine Pathway, and Vitamin D Shapes an Immunosuppressive Microenvironment in Acute Myeloid Leukemia.
作者: Amit Choudhary.;Ramya Ramesh.;Rakhee Kar.;Prakash Babu Narasimhan.;Prasanth Ganesan.;Biswajit Dubashi.;Rajesh Ng.;Soundravally R.;Smita Kayal.
来源: Asian Pac J Cancer Prev. 2026年27卷4期1239-1248页
Acute myeloid leukemia (AML) is a genetically heterogeneous malignancy. However, the immune microenvironment-including immune checkpoint pathways and metabolic regulators also plays a pivotal role in disease progression.
54. Phytochemical Analysis and Apoptosis-Inducing Anticancer Activity of Buddleja polystachia Leaf Extract against HeLa Cell Lines.
作者: Amete Mehari A.;Zenebe Teka M.;Teklemichael Tesfey.;Guesh Mulaw.;Neelima Pantagada.;Kamalakar Konuku.;Naveen Kumar Ad.;Tekleweyni Tadege.;Krishna Chaithanya K.
来源: Asian Pac J Cancer Prev. 2026年27卷4期1201-1210页
Cervical cancer is the second leading cause of mortality in women globally, with its incidence increasing due to multidrug resistance (MDR) and adverse side effects associated with chemotherapeutic agents. Hence, this study was carried out to investigate the selective cytotoxicity and apoptotic induction potential of Buddleja polystachya leaf diethyl ether (BPL-DE) extract on cervical cancer HeLa cell lines.
55. Tumor Lysis Syndrome in Lung Cancer Patients: A Review of the Literature.
作者: Zohair Siddiqui.;Andrew R Schab.;Awais Paracha.;Ali Abid.;Kasem Rifai.;Mahalia Huba.;Maha Arshad.;Maria Paracha.;Umar Durrani.;Hari Nair.;Bilawal Ahmed.
来源: Asian Pac J Cancer Prev. 2026年27卷4期1179-1188页
Tumor lysis syndrome (TLS) in patients with lung cancer (LC) is poorly characterized, due to its predominance in hematologic malignancies, creating a gap in both recognition and management strategies.
56. Performance of [68Ga]Ga-FAPI PET in Breast, Ovarian, and Cervical Cancers: A Systematic Review and Meta-Analysis.
作者: Madina Gabdullina.;Akmaral Ainakulova.;Umut Elboga.;Indira Karibayeva.;Galymzhan Alisherov.;Zhanar Zhakenova.;Jandos Amankulov.;Zhamilya Zholdybay.
来源: Asian Pac J Cancer Prev. 2026年27卷4期1161-1170页
This meta-analysis aims to evaluate the diagnostic efficacy of [68Ga]Ga-FAPI PET imaging in breast, ovarian, and cervical cancers by conducting a systematic review of the existing literature.
57. Chemotherapy Supports Cancer Cell Dissemination in a Melanoma Preclinical Model.
The aim of the study was to determine how the chemotherapeutic alkylating agent dacarbazine, together with the application of the miR-204-5p mimic in vivo, affects the presence of disseminated melanoma cells in distant organs - the lungs and liver.
58. Tailoring Management for Invasive Lobular Carcinoma: Imaging, Surgical Treatment, and Systemic Therapy Considerations.
作者: Rita A Mukhtar.;Matthew F Covington.;Kristina Fanucci.;Rinath Jeselsohn.
来源: Am Soc Clin Oncol Educ Book. 2026年46卷3期e520848页
Invasive lobular carcinoma (ILC) represents the most common special subtype of breast cancer. Studies show challenges with imaging, surgical therapy, and systemic therapy selection, arguing for the need for improved treatment personalization for this histologic subtype of breast cancer. While standard imaging tools have decreased sensitivity for ILC, newer imaging approaches may be more effective in both early and advanced disease settings. Surgical treatment is notable for high rate of positive margins and need for more extensive surgery; this may be mitigated by improved imaging and incorporation of particular techniques. While endocrine therapy remains the mainstay of treatment for most patients with ILC, the unique molecular characteristics of this tumor type may provide targets for new therapeutic approaches. The preponderance of data supports the need for ILC specific studies and trials.
59. IgD Multiple Myeloma: a Rare and Aggressive Entity: Report of Three Clinical Cases and Review of the Literature.
作者: El Mostafa Chachi.;Mounya Bouabdellah.;Sakina Derbal.;Fatiha El Oufir.;Nadia Safir.;Laila Benchekroun.
来源: Clin Lab. 2026年72卷3期
IgD multiple myeloma is an exceptionally rare subtype, accounting for less than 2% of all multiple myeloma cases.
60. Persistent Elevation of β-hCG Levels in a Patient with Primary Malignant Giant Cell Tumor of Bone: a Case Report and Literature Review.
Beta-human chorionic gonadotropin (β-hCG) is commonly used in pregnancy detection and as a tumor marker for reproductive system cancers.
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