444. In PAH with high risk for death, sotatercept reduced a composite of death, lung transplantation, or PAH hospitalization >24 h at 9 mo.
GIM/FP/GP: [Formula: see text] Pulmonology: [Formula: see text].
448. Nonpharmacologic and Pharmacologic Treatments of Adults in the Acute Phase of Major Depressive Disorder: A Living Clinical Guideline From the American College of Physicians (Version 1, Update Alert 3).
作者: Amir Qaseem.;Douglas K Owens.;Itziar Etxeandia-Ikobaltzeta.;J Thomas Cross.;Jennifer Yost.;Carolyn J Crandall.; .;Ethan M Balk.;Nick Fitterman.;Matthew Gibson.;Johanna Lewis.;Matthew C Miller.;Adam J Obley.;Katherine A Schmidt.;Paul G Shekelle.;Jeffrey A Tice.;Kate Carroll.;Curtis S Harrod.;Tatyana Shamliyan.;Chelsea Vigna.; .
来源: Ann Intern Med. 2025年178卷9期1-3页 449. In adults with active cancer and VTE, extended reduced-dose apixaban was noninferior to full-dose apixaban for VTE recurrence at 1 y.
GIM/FP/GP: [Formula: see text] Oncology: [Formula: see text] Hematology: [Formula: see text].
450. In insulin-treated T2D, automated insulin delivery reduced HbA1c without increasing hypoglycemic events vs. usual care at 13 wk.
GIM/FP/GP: [Formula: see text] Endocrinology: [Formula: see text].
451. After PCI with DES followed by DAPT, clopidogrel reduced MACCE vs. aspirin monotherapy at 2 y in patients with high risk for recurrence.
GIM/FP/GP: [Formula: see text] Cardiology: [Formula: see text].
452. Engineering Infection Controls to Reduce Indoor Transmission of Respiratory Infections : A Scoping Review.
作者: Amiran Baduashvili.;Lewis Radonovich.;Louis Leslie.;Stephanie Pease.;Claire Brickson.;Leela Chockalingam.;Natalie Banacos.;Beret Fitzgerald.;Jeffrey Wagner.;William P Bahnfleth.;Jean Cox-Ganser.;Kenneth R Mead.;Paula Olsiewski.;Cria O Gregory.;Erin Stone.;Joanna Taliano.;David N Weissman.;Lisa Bero.
来源: Ann Intern Med. 2025年178卷9期1314-1325页
Engineering infection controls include a wide range of interventions used indoors to reduce occupants' exposure to respiratory pathogens.
453. Update Alert 3: Nonpharmacologic and Pharmacologic Treatments of Adult Patients With Major Depressive Disorder: A Systematic Review and Network Meta-Analysis for a Clinical Guideline by the American College of Physicians.
作者: Andreea Iulia Dobrescu.;Isabel Moser.;Irma Klerings.;Gerald Gartlehner.
来源: Ann Intern Med. 2025年178卷9期1-3页 456. High Tibial Osteotomy for Medial Compartment Knee Osteoarthritis : A Randomized Trial With Parallel Preference Arm.
作者: Trevor B Birmingham.;Codie A Primeau.;Rebecca F Moyer.;Dianne M Bryant.;Jinhui Ma.;Kristyn M Leitch.;Wolfgang Wirth.;Ryan Degen.;Alan M Getgood.;Robert B Litchfield.;Kevin R Willits.;Felix Eckstein.;J Robert Giffin.
来源: Ann Intern Med. 2025年178卷9期1238-1248页
Medial opening wedge high tibial osteotomy (HTO) is a limb realignment surgery that aims to preserve joint structure and improve clinical outcomes by redistributing ambulatory loads on the knee among patients with knee osteoarthritis and varus alignment.
457. Rituximab Versus Conventional Therapy for Remission Induction in Eosinophilic Granulomatosis With Polyangiitis : A Randomized Controlled Trial.
作者: Benjamin Terrier.;Grégory Pugnet.;Claire de Moreuil.;Bernard Bonnotte.;Ygal Benhamou.;Dominique Chauveau.;Marie-Charlotte Besse.;Pierre Duffau.;Nicolas Limal.;Antoine Néel.;Geoffrey Urbanski.;Noémie Jourde-Chiche.;Nicolas Martin-Silva.;Julien Campagne.;Arsène Mekinian.;Nicolas Schleinitz.;Felix Ackermann.;Anne-Laure Fauchais.;Antoine Froissart.;Thomas Le Gallou.;Yurdagul Uzunhan.;Jean-François Viallard.;Alice Bérezné.;Laurent Chiche.;Camille Taillé.;Guillaume Direz.;Cécile-Audrey Durel.;Pascal Godmer.;Salim Trad.;Marc Lambert.;Mathilde de Menthon.;Thomas Quéméneur.;Jacques Cadranel.;Pierre Charles.;Antoine Dossier.;Léa Jilet.;Loïc Guillevin.;Hendy Abdoul.;Xavier Puéchal.; .
来源: Ann Intern Med. 2025年178卷9期1249-1257页
Eosinophilic granulomatosis with polyangiitis (EGPA) is an eosinophilic antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Rituximab has emerged as the standard of care in other types of ANCA-associated vasculitis, but controlled studies on its use in EGPA are yet lacking.
458. Social Determinants of Health and Risk for Long COVID in the U.S. RECOVER-Adult Cohort.
作者: Candace H Feldman.;Leah Santacroce.;Ingrid V Bassett.;Tanayott Thaweethai.;Radica Alicic.;Rachel Atchley-Challenner.;Alicia Chung.;Mark P Goldberg.;Carol R Horowitz.;Karen B Jacobson.;J Daniel Kelly.;Stacey Knight.;Karen Lutrick.;Praveen Mudumbi.;Sairam Parthasarathy.;Heather Prendergast.;Yuri Quintana.;Nasser Sharareh.;Judd Shellito.;Zaki A Sherif.;Brittany D Taylor.;Emily Taylor.;Joel Tsevat.;Zanthia Wiley.;Natasha J Williams.;Lynn Yee.;Lisa Aponte-Soto.;Jhony Baissary.;Jasmine Berry.;Alexander W Charney.;Maged M Costantine.;Alexandria M Duven.;Nathaniel Erdmann.;Kacey C Ernst.;Elen M Feuerriegel.;Valerie J Flaherman.;Minjoung Go.;Kellie Hawkins.;Vanessa Jacoby.;Janice John.;Sara Kelly.;Elijah Kindred.;Adeyinka Laiyemo.;Emily B Levitan.;Bruce D Levy.;Jennifer K Logue.;Jai G Marathe.;Jeffrey N Martin.;Grace A McComsey.;Torri D Metz.;Tony Minor.;Aoyjai P Montgomery.;Janet M Mullington.;Igho Ofotokun.;Megumi J Okumura.;Michael J Peluso.;Kristen Pogreba-Brown.;Hengameh Raissy.;Johana M Rosas.;Upinder Singh.;Timothy VanWagoner.;Cheryl R Clark.;Elizabeth W Karlson.
来源: Ann Intern Med. 2025年178卷9期1287-1297页
Social determinants of health (SDoH) contribute to disparities in SARS-CoV-2 infection, but their associations with long COVID are unknown.
459. The Risks of Risk Assessment: Causal Blind Spots When Using Prediction Models for Treatment Decisions.
作者: Nan van Geloven.;Ruth H Keogh.;Wouter van Amsterdam.;Giovanni Cinà.;Jesse H Krijthe.;Niels Peek.;Kim Luijken.;Sara Magliacane.;Paweł Morzywołek.;Thijs van Ommen.;Hein Putter.;Matthew Sperrin.;Junfeng Wang.;Daniala L Weir.;Vanessa Didelez.
来源: Ann Intern Med. 2025年178卷9期1326-1333页
Clinicians increasingly rely on prediction models to guide treatment choices. Most prediction models, however, are developed using observational data that include some patients who have already received the treatment the prediction model is meant to inform. Special attention to the causal role of those earlier treatments is required when interpreting the resulting predictions. "Causal blind spots" were identified in 3 common approaches to handling treatment when developing a prediction model: including treatment as a predictor, restricting to persons taking a certain treatment, and ignoring treatment. Through several real examples, this article illustrates how the risks obtained from models developed using such approaches may be misinterpreted and can lead to misinformed decision making. The discussion covers issues attributable to confounding, selection, mediation, and changes in treatment protocols over time. An extension of guidelines for the development, reporting, and evaluation of prediction models is advocated to avoid such misinterpretations. Developers must ensure that the intended target population for the model, and the treatment conditions under which predictions hold, are clearly communicated. When prediction models are intended to inform treatment decisions, they need to provide estimates of risk under the specific treatment (or intervention) options being considered, known as "prediction under interventions." Next to suitable data, this requires causal reasoning and causal inference techniques during model development and evaluation. Being clear about what a given prediction model can and cannot be used for prevents misinformed treatment decisions and thereby prevents potential harm to patients.
460. Cardiovascular Risk Factor and Disease Mortality Among Asian Indian, Chinese, and Filipino Adults in the United States, 2018 to 2023.
作者: Rahul Aggarwal.;Rishi K Wadhera.;Nicholas Chiu.;Michael Szarek.;Deepak L Bhatt.
来源: Ann Intern Med. 2025年178卷10期1523-1525页 |