Idiopathic inflammatory myopathies (IIM) are heterogeneous disorders that often affect the lungs as IIM-associated interstitial lung disease (IIM-ILD). We used Meta-ANalysis of Transethnic Associations (MANTRA) and machine learning methods to evaluate predictors of IIM-ILD.

Pain is a critical symptom to assess in clinical care and trials. This study aimed to explore experiences of pain in adults with myositis.

The objective of this study was to investigate associations between age at SSc onset and serologic, clinical, and proteomic characteristics in the Renji Scleroderma Longitudinal Cohort (Renji-SLOC).

Behçet's disease (BD) is a multisystem vasculitis with variable paediatric presentations. Early diagnosis may be difficult due to heterogeneous manifestations and limited applicability of existing criteria. This study compared clinical characteristics by age at onset and examined factors contributing to diagnostic delay.

To evaluate the effectiveness and safety of rituximab (RTX) compared to cyclophosphamide (CYC) in inducing remission with ANCA-associated vasculitis (AAV).

Despite advances in the treatment of psoriatic arthritis (PsA), a substantial proportion of patients continue to report persistent symptoms and impaired quality of life. However, terminology remains inconsistent for patients who fail to achieve disease control despite treatment, which limits research comparability and contributes to therapeutic inertia. To address this gap, a Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) task force developed consensus definitions for two distinct states: complex-to-manage PsA (C2M-PsA) and treatment-refractory PsA (TR-PsA). C2M-PsA is defined as a state of persistent symptoms despite treatment with at least one biologic or targeted synthetic DMARD (b/tsDMARD), extending beyond biological non-response to include factors such as comorbidities, overlapping conditions, psychosocial burden and treatment-related challenges (for example, non-adherence). TR-PsA, a more specific subset of C2M-PsA, is characterized by failure of at least three therapies with distinct mechanisms of action (including at least two biologic/targeted synthetic DMARDs), persistent symptoms considered problematic by both patient and clinician, and objective evidence of ongoing inflammation - after ruling out alternative explanations for treatment refractoriness. These consensus-derived GRAPPA definitions provide a shared framework to standardize terminology, support individualized care, and improve patient stratification in research and practice. Prospective validation across diverse settings and phenotypes is needed to confirm their reliability, responsiveness and clinical utility.

Rheumatoid arthritis (RA) is a systemic autoimmune disease with articular and extra-articular manifestations. Chronic inflammation may contribute to sarcopenia independently of age. While cross-sectional studies report sarcopenia in 24-30% of RA patients, longitudinal data remain limited. This study aimed to assess long-term changes in sarcopenia and body composition in RA patients and explore their associations with clinical features and health outcomes.

Hip morphology has emerged as an important factor in the development of hip osteoarthritis (OA). Cam morphology is one of the most common hip morphologies, characterized by a bony prominence around the femoral head-neck junction of the hip that alters the normal shape of the femoral head. Cam morphology can contribute to intra-articular joint damage by generating abnormal contact stresses at this junction, initiating femoroacetabular impingement (FAI) syndrome and eventually leading to hip OA. Cam morphology is a causal risk factor for hip OA, but not everybody with this morphology will develop FAI syndrome or OA. The pathogenesis of hip disease is probably driven by the interplay between cam morphology, other coexisting hip morphologies (such as pincer morphology), femoral version, spinopelvic parameters and biomechanical and environmental factors. Early identification of FAI syndrome could enable timely, multidisciplinary intervention and offers the potential to modify the trajectory of disease. Cam morphology can develop during skeletal maturation, particularly in adolescents participating in high-joint-load physical activity, raising important questions about preventative approaches. Management of FAI syndrome includes both surgical and non-surgical approaches. Emerging insights into the pathogenesis and detection of cam morphology are paving the way for more targeted interventions and a deeper understanding of its role in FAI syndrome and hip OA development.

Ankylosing spondylitis (AS) often affects individuals during their most productive working years. However, few studies have investigated factors influencing employment in Japanese AS patients. This study investigates the employment status and related factors in Japanese patients with ankylosing spondylitis.

The objective of this study was to validate the achievement of treat-to-target (T2T) in childhood-onset SLE (cSLE) at Wuhan Children's Hospital.

VEXAS syndrome is a severe systemic haemato-inflammatory disease with heterogeneous clinical presentations. Most patients experience recurrent inflammatory flares despite anti-inflammatory therapy. The lack of accepted definitions of flare in these patients is preventing development of disease activity tools that are essential for conducting clinical trials. We aimed to develop a consensus definition of a VEXAS flare for use in clinical trials.

The increase in biological disease-modifying antirheumatic drugs for psoriatic arthritis (PsA) made it possible to consider different mechanisms of action (MoA) after the failure of the first advanced-line therapy. However, there is still a lack of real-world evidence comparing the cycling (re-administration of a similar MoA) and the swap strategy. This retrospective observational study aims to evaluate the retention rate, as a proxy for effectiveness, of second-line therapeutic options after the failure of a TNF inhibitor (TNFi) by comparing cycling versus swap strategies.