402. Iron Deficiency in Adults: A Review.
Absolute iron deficiency, defined as low iron stores with or without anemia, affects approximately 2 billion people worldwide and 14% of adults in the US. Iron-deficiency anemia, defined as low hemoglobin due to low iron stores, affects approximately 1.2 billion people worldwide, including 10 million in the US.
404. Prothrombin Complex Concentrate vs Frozen Plasma for Coagulopathic Bleeding in Cardiac Surgery: The FARES-II Multicenter Randomized Clinical Trial.
作者: Keyvan Karkouti.;Jeannie L Callum.;Justyna Bartoszko.;Kenichi A Tanaka.;Sigurd Knaub.;Sukhpal Brar.;Kamrouz Ghadimi.;Antoine Rochon.;Darren Mullane.;Etienne J Couture.;Yulia Lin.;Christopher Harle.;Michelle Zeller.;Diem T T Tran.;Cristina Solomon.;Vivek Rao.;Michael Law.;Amir L Butt.;Edward P Chen.;Maria Rosal Martins.;Tarit Saha.;Andrew W Shih.;Marie-Claude Vézina.;Fuad Moussa.;Raffael Pereira Cezar Zamper.;Summer Syed.;Hakan Buyukdere.;Sylvia Werner.;Deep Grewal.;Daniel Wong.;Kofi B Vandyck.;Robert Tanzola.;Bevan Hughes.;Olivier Royer.;Sophia Wong.;Jerrold H Levy.; .
来源: JAMA. 2025年333卷20期1781-1792页
Excessive bleeding is a common and prognostically important complication of cardiac surgery. For bleeding related to coagulation factor deficiency, frozen plasma is the most used therapy. Preliminary trials indicate that 4-factor prothrombin complex concentrate (PCC) may be a suitable alternative.
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