34. Translational social medicine for global health: introducing Cases in Global Social Medicine.
作者: Seth M Holmes.;Mayssa Rekhis.;Scott D Stonington.;Mirko Pasquini.;Luke Messac.;Eugene Raikhel.;Junko Kitanaka.;Valéria Macedo.;Paola Sesia.;Carlos Piñones Rivera.;Tinashe Goronga.;Salmaan Keshavjee.;Benson A Mulemi.;Margareta Matache.;Michael Marmot.
来源: Lancet. 2025年406卷10517期2306-2307页 38. Efficacy and safety of allogeneic CD19 CAR NK-cell therapy in systemic lupus erythematosus: a case series in China.
作者: Jie Gao.;Mengtao Li.;Ming Sun.;Yiyi Yu.;Ruina Kong.;Xia Xu.;Suxuan Liu.;Qian Chen.;Xiaofang Li.;Yang Wu.;Enshun Xu.;Jianmin Yang.;Dongbao Zhao.
来源: Lancet. 2025年
Lately, autologous CD19-targeting chimeric antigen receptor (CAR) T cells have shown excellent efficacy in treatment of autoimmune diseases, but with great safety concerns, such as infections. In this study, we aimed to evaluate the safety, tolerability, and efficacy of allogeneic CD19 CAR natural killer (NK)-cell therapy in patients with relapsed or refractory systemic lupus erythematosus (SLE).
39. Safety and efficacy of weekly pemvidutide versus placebo for metabolic dysfunction-associated steatohepatitis (IMPACT): 24-week results from a multicentre, randomised, double-blind, phase 2b study.
作者: Mazen Noureddin.;Stephen A Harrison.;Rohit Loomba.;Naim Alkhouri.;Naga Chalasani.;Muhammad Y Sheikh.;Shaheen Tomah.;Julio A Gutierrez.;Silvia Urbina.;John J Suschak.;Randy Brown.;Ozioma Odili.;Jay Yang.;Stephine Keeton.;Guy Neff.;Edward Mena.;M Scot Roberts.;Sarah K Browne.;M Scott Harris.
来源: Lancet. 2025年
GLP-1-glucagon dual receptor agonists such as pemvidutide have shown promise in treating metabolic dysfunction-associated steatohepatitis (MASH). The aim of this trial was to assess the effects of pemvidutide on MASH resolution and fibrosis improvement in patients with liver fibrosis stage F2 or F3 MASH at 24 weeks of treatment.
|