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21. Efficient diagnosis for endoscopic remission in Crohn's diseases by the combination of three non-invasive markers.
作者: Kensuke Takei.;Toshihiro Inokuchi.;Sakiko Hiraoka.;Mikako Ishiguro.;Junki Toyosawa.;Yuki Aoyama.;Shoko Igawa.;Keiko Takeuchi.;Yasushi Yamasaki.;Hideaki Kinugasa.;Masahiro Takahara.;Seiji Kawano.;Toshiharu Mitsuhashi.;Motoyuki Otsuka.
来源: BMC Gastroenterol. 2025年25卷1期364页
Serum C-reactive protein (CRP), leucine-rich alpha-2 glycoprotein (LRG), and fecal calprotectin (Fcal) are non-invasive markers used to assess Crohn's disease (CD) severity. However, the accuracy of these markers alone is often limited, and most previous reports have evaluated the efficacy of each marker individually. We aimed to improve the diagnostic performance of endoscopic remission (ER) of CD by combining these 3 markers.
22. Evaluating the diagnostic significance of the R2* value on 3.0T MRI for assessing the severity of warm hepatic ischemia-reperfusion injury.
Magnetic resonance imaging (MRI) may be a non-invasive tool for managing warm hepatic ischemia-reperfusion injury (WHIRI).
23. ERMAP attenuates DSS-induced colitis in mice by regulating macrophage and T cell functions.
作者: Lu Xia.;Yiwen Pan.;Xianbin Wang.;Rong Hu.;Jie Gao.;Wei Chen.;Keke He.;Dongbin Cui.;Youbo Zhao.;Lu Liu.;Laijun Lai.;Min Su.
来源: BMC Gastroenterol. 2025年25卷1期362页
Both macrophages and T cells play a critical role in inflammatory bowel disease (IBD) development. Since our previous studies have shown that a novel immune checkpoint molecule erythrocyte membrane-associated protein (ERMAP) affects macrophage polarization and negatively regulates T cell responses, we investigated the effects of ERMAP on DSS-induced colitis progression in mice.
24. Association of clinicopathological factor with lymph node metastasis in rectal cancer patients: a retrospective cohort study.
作者: Yangfeng Lin.;Zhijie You.;Zhijing Lin.;Siming Wang.;Guohua Yang.
来源: BMC Gastroenterol. 2025年25卷1期358页
Systemic inflammatory response (SIR) indicators serve as predictive factors for lymph node metastasis (LNM) in various cancers. This study aimed to investigate the association of platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) with LNM in rectal cancer and to identify clinicopathological factors linked to LNM.
25. Dual energy CT-derived quantitative parameters and hematological characteristics predict pathological complete response in neoadjuvant chemoradiotherapy esophageal squamous cell carcinoma patients.
作者: Miaomiao Li.;Yongbin Cui.;Yuanyuan Yan.;Junfeng Zhao.;Xinjun Lin.;Qianyu Liu.;Shushan Dong.;Mingming Nie.;Yong Huang.;Baosheng Li.;Yong Yin.
来源: BMC Gastroenterol. 2025年25卷1期357页
There is no gold standard method to predict pathological complete response (pCR) in esophageal squamous cell carcinoma (ESCC) patients before surgery after neoadjuvant chemoradiotherapy (nCRT). This study aims to investigate whether dual layer detector dual energy CT (DECT) quantitative parameters and clinical features could predict pCR for ESCC patients after nCRT.
26. A novel framework for esophageal cancer grading: combining CT imaging, radiomics, reproducibility, and deep learning insights.
作者: Muna Alsallal.;Hanan Hassan Ahmed.;Radhwan Abdul Kareem.;Anupam Yadav.;Subbulakshmi Ganesan.;Aman Shankhyan.;Sofia Gupta.;Kamal Kant Joshi.;Hayder Naji Sameer.;Ahmed Yaseen.;Zainab H Athab.;Mohaned Adil.;Bagher Farhood.
来源: BMC Gastroenterol. 2025年25卷1期356页
This study aims to create a reliable framework for grading esophageal cancer. The framework combines feature extraction, deep learning with attention mechanisms, and radiomics to ensure accuracy, interpretability, and practical use in tumor analysis.
28. Prolonged time to treatment of biologics in inflammatory bowel disease: disparities from a retrospective study in a tertiary referral centre in the UK.
作者: Charlotte Wong.;Paul Bassett.;Nikolaos Kamperidis.;Ravi Misra.;Lisa Younge.;Lovesh Dyall.;Katie Yeung.;Christy Rejee.;Naila Arebi.
来源: BMC Gastroenterol. 2025年25卷1期352页
Several disparities in healthcare utilisation and delivery are reported in inflammatory bowel disease (IBD). We examined disparities for delays in biologic administration.
29. Diagnostic accuracy and influencing factors of microprobe endoscopic ultrasound for gastrointestinal subepithelial lesions: a multicenter retrospective study.
作者: Jiao Li.;Yongfeng Yan.;Dandan Jiang.;Xiaoxiang Wang.;Li Wang.;Li Liu.;Tao Shu.;Zhengkui Zhou.;Xiaobin Sun.
来源: BMC Gastroenterol. 2025年25卷1期353页
Microprobe endoscopic ultrasonography (MEUS) has been widely adopted in primary hospitals due to its affordability, ease of use, and simple operation. This study aims to assess the diagnostic accuracy of MEUS in classifying gastrointestinal subepithelial lesions (SELs), identify key influencing factors, and explore strategies for improvement.
30. Milligan-Morgan hemorrhoidectomy combined with rubber band ligation and polidocanol foam sclerotherapy for the management of grade III/IV hemorrhoids: a retrospective study.
Hemorrhoids are one of the most common and annoying benign diseases in the field of colorectal surgery. A Milligan-Morgan hemorrhoidectomy (MMH) is the most frequently applied surgical technique due to its clear efficacy and high success rate, but the reported postoperative complications remain a major problem. This study aimed to retrospectively evaluate the efficacy and safety of a MMH combined with rubber band ligation and polidocanol foam sclerotherapy (MMH + RBL + PFS) for the management of grade III/IV hemorrhoids.
31. Association of cardiometabolic index with gallstone disease and insulin resistance based on NHANES data.
Cardiometabolic index (CMI) is an index integrating visceral obesity and dyslipidemia. This study intends to scrutinize the connection between CMI and gallstone disease (GSD) and to elucidate the association between CMI and insulin resistance (IR) in patients with GSD.
32. Care needs profiles of Crohn's disease patients and their associations with symptom clusters, post-traumatic growth, and family function: a latent profile analysis.
作者: Rongfei Duan.;Wan Mei.;Ming Lei.;Danlei Chen.;Ting Pan.;Fang Kong.;Yan Chen.
来源: BMC Gastroenterol. 2025年25卷1期351页
The care needs of patients with Crohn's disease (CD) may be heterogeneous. This study aimed to explore the latent class of care needs of patients with CD and differences in their characteristics and to analyze the factors influencing the different latent classes.
33. Predicting the risk of lymph node metastasis in colon cancer: development and validation of an online dynamic nomogram based on multiple preoperative data.
作者: Longlian Deng.;Lemuge Che.;Haibin Sun.;Riletu En.;Bowen Ha.;Tao Liu.;Tengqi Wang.;Qiang Xu.
来源: BMC Gastroenterol. 2025年25卷1期350页
Predicting lymph node metastasis (LNM) in colon cancer (CC) is crucial to treatment decision-making and prognosis. This study aimed to develop and validate a nomogram that estimates the risk of LNM in patients with CC using multiple clinical data from patients before surgery.
34. The prognostic value of AST-lymphocyte ratio index in liver cancer patients treated with TACE: a systematic review and single-center retrospective study.
作者: Yali Tian.;Lina Ma.;Shuaiwei Liu.;Xiaoyang Bai.;Nawaz Shah.;Le Zhang.;Xia Wang.;Yuxi Zhang.;Xiangchun Ding.
来源: BMC Gastroenterol. 2025年25卷1期348页
AST-lymphocyte ratio index (ALRI) has been proposed as a potentially prognostic indicator of liver cancer patients underwent transcatheter arterial chemoembolization (TACE) in studies, but the numbers were small and the results were controversial. In this study, we systematically assessed the prognostic value of ALRI in liver cancer patients treated with TACE by integrating meta-analysis with single-center clinical analysis.
35. Identification of the "Collagen-Macrophage" sub-category of patients with colorectal cancer as an extension of the CMS4 subtype with THBS2 as a therapeutic target.
作者: Shuwen Chen.;Zhaoyan Jiang.;Wanxuan Song.;Chuqiao Lu.;Yanbing Lin.;Shiyao Xu.;Kunxin Xie.;Li Wan.;Xiaoqin Yuan.
来源: BMC Gastroenterol. 2025年25卷1期342页
We identified a subset of patients with colorectal cancer (CRC) enriched with "collagen-TAMs," designated the CM class, using large integrated colon cancer transcriptome and single-cell transcriptome datasets. This classification system could be used as an extension of the traditional CMS classification system for CRC to guide more accurate classification and treatment.We also screened CAF-derived THBS2 as a potential biomarker for CM and found that it plays an important role in CRC disease models in vitro and in vivo, promoting tumor development and metastasis as well as TAM recruitment. Targeting THBS2 combined with PD-1 therapy effectively improved the therapeutic effect of immunotherapy in vivo. The CM classification provides a new perspective for CRC treatment, and THBS2, which is highly expressed in CM cases, can be used as a new potential combined target for immunotherapy.
36. M64HCl, a focal adhesion kinase activator, promotes intestinal mucosal healing in rats.
作者: Guiming Liu.;Ahmed Adham R Elsayed.;Louis Boafo Kwantwi.;Ricardo Gallardo-Macias.;Vadim J Gurvich.;Marc D Basson.
来源: BMC Gastroenterol. 2025年25卷1期347页
Intestinal mucosal injury may arise from various factors. While many drugs target the causative factors, none directly stimulate mucosal wound healing. We found that the specific focal adhesion kinase (FAK) activator, M64HCl, promotes intestinal mucosal healing in mice. This study aims to further validate the therapeutic impact of M64HCl on intestinal mucosal repair in rats as a second species.
37. Association between Dietary Inflammatory Index and Ulcerative Colitis: a case-control study.
作者: Huiyue Pan.;Leilei Zhai.;Min Cui.;Yingying Liu.;Limei Shao.;Ling Liu.;Ping Yao.
来源: BMC Gastroenterol. 2025年25卷1期343页
Diet plays a crucial role in the activity and onset of ulcerative colitis (UC). The aim of this study was to comprehensively explore the association between the dietary inflammatory index (DII) and UC.
38. Formation of non-cholesterol gallstones in populations within clonorchiasis endemic regions is closely related to Clonorchis sinensis infection.
作者: Xiaobing Luo.;Ruihong Ma.;Hongying Cai.;Xiangyu Su.;Sangui Wang.;Tie Qiao.
来源: BMC Gastroenterol. 2025年25卷1期345页
Numerous risk factors are linked to gallbladder stone disease (GBSD). Nonetheless, the relationship between Clonorchis sinensis (C. sinensis) and this condition remains to be clarified.
39. Diagnostic challenges of inflammatory submucosal tumor-like lesions: a multicenter propensity score-matching analysis.
作者: Mengting Yu.;Jiao Li.;Yongfeng Yan.;Xiaoxiang Wang.;Yanhui Mao.;Dandan Jiang.;Zhengkui Zhou.;Yuanyuan Chen.;Xiaobin Sun.
来源: BMC Gastroenterol. 2025年25卷1期346页
Gastrointestinal submucosal tumors (SMTs) are frequently encountered in clinical practice, with diverse etiologies and overlapping endoscopic features. Inflammatory SMT-like lesions (I-SMTLs), though rare and benign, mimic SMTs endoscopically but are fundamentally inflammatory. Limited research exists on their specific diagnostic characteristics.
40. Preoperative immune prognostic index predicts the prognosis and postoperative adjuvant chemotherapy benefits of esophageal squamous cell carcinoma after minimally invasive esophagectomy.
作者: Jin Huang.;Chao Chen.;Yan-Ming Shen.;Yun-Fan Luo.;Zhao-Min Sun.;Jie Chen.;Shao-Jun Xu.;Ji-Hong Lin.;Shu-Chen Chen.
来源: BMC Gastroenterol. 2025年25卷1期344页
The utility of the immune prognostic index (IPI) for esophageal squamous cell carcinoma (ESCC) has yet to be established after minimally invasive esophagectomy (MIE). The purpose of this study was to investigate the value of IPI in predicting the prognosis and postoperative adjuvant chemotherapy (AC) benefits of ESCC patients.
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