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341. Liver stiffness by non-invasive tests predicts hepatocellular carcinoma and liver-related complications following viral eradication with direct-acting antivirals in chronic hepatitis C: a retrospective cohort study.
作者: Prooksa Ananchuensook.;Sombat Treeprasertsuk.;Piyawat Komolmit.;Kessarin Thanapirom.
来源: BMC Gastroenterol. 2026年26卷1期
High sustained virological response (SVR) was achieved after direct-acting antiviral (DAA) treatment in patients with chronic hepatitis C viral (HCV) infection. Nevertheless, the factors predicting hepatocellular carcinoma (HCC) and liver-related complications (LRC) following SVR are required.
342. Development of a CT radiomics nomogram for preoperative prediction of differentiation grading in pancreatic ductal adenocarcinoma: a two-center retrospective study.
To investigate the value of the nomogram based on preoperative enhanced computed tomography (CT) radiomics in predicting the differentiation grade of pancreatic ductal adenocarcinoma (PDAC).
343. Liver CT-based composite biomarkers can identify MASH and steatosis grade in people with obesity prior to bariatric surgery: a retrospective study.
作者: Hailong Zhang.;Zhuoru Jiang.;Huanhuan Zheng.;Haoyao Wang.;Liankun Xia.;Jun Chen.;Bing Zhang.
来源: BMC Gastroenterol. 2026年26卷1期
Hepatic steatosis is a precursor to metabolic dysfunction-associated steatohepatitis (MASH), which is linked to obesity and diabetes and poses a risk for liver cirrhosis and cancer. For detecting MASH and hepatic steatosis, liver biopsy is the reference method, but it is invasive and impractical for repeated monitoring of treatment efficacy. Our goal was to develop a convenient and non-invasive tool for accurately identifying MASH and steatosis grade in people with obesity.
344. ADGRF4 and ADGRL4 as novel prognostic biomarkers and potential therapeutic implications in stomach adenocarcinoma.
作者: Jia-Hui Wang.;Ming-Jun Li.;Dan-Dan Zang.;Xiao-Wei Wang.;Peng Huang.
来源: BMC Gastroenterol. 2026年26卷1期
This study explored the differential expression of adhesion G protein-coupled receptor (ADGR) genes in stomach adenocarcinoma (STAD), evaluated their association with STAD prognosis, and explored their potential therapeutic implications.
345. Effect of preoperative anemia on postoperative outcomes in mixed hemorrhoids: a retrospective observational study.
Anemia is a common complication of long-term hematochezia in patients with mixed hemorrhoids. This study aimed to evaluate the effect of preoperative anemia on the prognosis of mixed hemorrhoids after Milligan-Morgan hemorrhoidectomy.
346. A prospective cohort-based prediction model incorporating acute gastrointestinal injury for 28-day and 90-day outcomes in acute decompensation of cirrhosis.
作者: Jia Lian.;Hao Cui.;Baiguo Xu.;Qing Ye.;Lei Liu.;Fang Liu.;Lixia Sun.;Ying Luo.;Li Sun.;Yue Huang.;Tongyuan Xue.;Tao Han.
来源: BMC Gastroenterol. 2026年26卷1期
This prospective, observational study evaluated the role of acute gastrointestinal injury (AGI) in the 28-day and 90-day prognosis of cirrhotic patients with acute decompensation (AD).
347. CT semantic features of primary gastric cancer: a preoperative predictive model for peritoneal metastasis with superior efficacy to conventional direct CT assessment.
This study aims to evaluate the utility of CT semantic features of primary Gastric Cancer(GC) compared to conventional CT assessments for predicting Peritoneal Metastasis(PM) , and to construct a preoperative predictive model.
349. Hepatitis E virus seroprevalence and infection status among patients with inflammatory bowel disease undergoing advanced therapy: a prospective single-center observational study.
作者: Dimitrije Damjanov.;Jelena Stojčević Maletić.;Tamaš Petrović.;Željka Savić.;Milica Knežević.;Vladimir Gajdov.;Maja Ružić.
来源: BMC Gastroenterol. 2026年26卷1期
Hepatitis E virus (HEV) is a significant cause of acute and chronic hepatitis, especially in immunosuppressed individuals. Patients with inflammatory bowel disease (IBD) undergoing advanced therapy may have an elevated risk of persistent HEV infection; however, evidence in this population is limited. This study evaluated HEV seroprevalence and infection status among IBD patients receiving advanced therapy in an endemic European region.
350. POEM-based endoscopic myotomy for esophageal diverticulum: a case series study.
In recent years, the submucosal tunneling principle underlying Peroral endoscopic myotomy (POEM) has emerged as a minimally invasive endoscopic option for the treatment of esophageal diverticulum (ED). However, evidence regarding its effectiveness across different types of ED remains limited. This study aimed to evaluate the clinical efficacy and safety of endoscopic myotomy for the management of esophageal diverticulum.
351. Mapping the evolution of inflammatory bowel disease care in Brazil: a comparison of cross-sectional surveys from 2017 and 2023.
作者: Marta Brenner Machado.;Andreia Vieira.;Silvana Paiva Orlandi.;Mariana Otero Xavier.;Letícia Becari Cal de Souza.;Maria Izabel Lamounier de Vasconcelos.;Luciana Schuck Guedes.
来源: BMC Gastroenterol. 2026年26卷1期
In Brazil, the epidemiology and care pathways of patients with inflammatory bowel disease (IBD) are poorly documented. Mapping the patient journey is key to identifying gaps and informing health policies. This study explores the Second Journey of IBD patients in Brazil and compares the findings with those from the First Journey.
352. Establishment of prognostic prediction model based on lipid metabolism related genes in esophageal squamous cell carcinoma by machine learning algorithms.
Esophageal squamous cell carcinoma (ESCC) is a major cause of cancer-related mortality worldwide, with a high prevalence and poor prognosis in specific regions. Despite advancements in clinical care, the identification of reliable biomarkers for accurate survival prediction remains a significant challenge, hindering personalized treatment.
353. Electronic nose versus gas chromatography - mass spectrometry for diagnostic discrimination of advanced hepatocellular carcinoma by volatolomic analysis.
作者: Moustafa S Mahmoud.;Mohamed S Mshaly.;Hend N Abdel-Reheim.;Mamdouh M Shawki.;Radwa A Meshref.;Ehab I Mohamed.
来源: BMC Gastroenterol. 2026年26卷1期
Hepatocellular carcinoma (HCC), the third leading cause of cancer-related mortality, is often diagnosed late due to lack of early symptoms. Electronic nose (eNose) technology has been used to detect volatile organic compounds (VOCs) in exhaled breath with moderate accuracy. This study investigated eNose versus gas chromatography-mass spectrometry (GC-MS) for volatolomic analysis of blood and urine headspace to improve HCC diagnosis.
354. Clinical outcomes after deep enteroscopy in patients with obscure gastrointestinal bleeding: a single-center retrospective study.
Double balloon enteroscopy (DBE) is a key diagnostic and therapeutic tool for small bowel pathologies, particularly in patients with obscure gastrointestinal bleeding (OGIB). Although DBE's diagnostic value is well established, long-term quantitative data on hemoglobin recovery and transfusion needs remain limited.
355. Efficacy and safety of dual biologics or combination therapy with JAK inhibitors in refractory inflammatory bowel disease: a retrospective single-center real-world study from China.
作者: Jiao-Jiao Wei.;Yi-Bing Hu.;Ya-Fang Li.;Chong Lu.;Min-Li Hu.;Xiao-Yun Yang.;Jin Ding.;Qun-Ying Wang.
来源: BMC Gastroenterol. 2026年26卷1期
There is limited data on the efficacy and safety of combination therapy of dual biologics or small molecules combined with biologics in inflammatory bowel disease (IBD) patients in China. The present retrospective study determined the efficacy and safety of these combinations in Chinese IBD patients.
356. Predicting biliary complications after liver transplantation: a machine learning and nomogram-based exploratory study.
作者: Han Zhang.;Jinxi Chen.;Minghang Zhang.;Kezhen Zong.;Shanshan Li.;Zuotian Huang.;Zhongjun Wu.
来源: BMC Gastroenterol. 2026年26卷1期
Accurate risk stratification of biliary complications (BCs) after liver transplantation (LT) remains challenging. This study aimed to develop and validate a machine learning (ML) and nomogram framework comprising a ML-based web calculator and a clinically interpretable nomogram for post-LT BCs.
357. Operative, safety and economic outcomes of endoscopic submucosal dissection in older adults: a retrospective real-world analysis.
作者: Xiao-Dong Zhang.;Jin-Hong Tang.;Yu-Ling Chong.;Xiao-Hong Zhang.;Li Feng.
来源: BMC Gastroenterol. 2026年26卷1期
Endoscopic submucosal dissection (ESD) is a cornerstone organ-preserving treatment for colorectal neoplasia; however, the impact of advanced age on procedural efficiency, safety, and economic burden remains controversial. This study aimed to comprehensively evaluate these outcomes in older adults within a real-world clinical setting.
358. Clinical outcomes of transcatheter arterial embolization in patients with angiography-negative duodenal ulcer bleeding after failed endoscopic hemostasis.
作者: Shoulin Zhang.;Zongcai Liu.;Zezhong Gong.;Yanyang Wu.;Yi Wu.;Yunfei Tian.
来源: BMC Gastroenterol. 2026年26卷1期
Duodenal ulcer bleeding is a common cause of non-variceal upper gastrointestinal bleeding. Although endoscopic hemostasis is recommended as the first-line treatment, a subset of patients experience failure of endoscopic therapy and require further intervention, for which transcatheter arterial embolization (TAE) has become a commonly used salvage treatment. In clinical practice, however, angiography may fail to demonstrate definite active bleeding, posing challenges for subsequent therapeutic decision-making. Under such circumstances, empiric embolization is frequently performed, yet its clinical outcomes have not been systematically evaluated.
359. Urban-rural disparities in survival of Chinese esophageal squamous cell carcinoma: a cohort study of 133,064 cases.
作者: Ran Wang.;Zong Min Fan.;Kan Zhong.;Xue Ke Zhao.;Xue Na Han.;Ling Ling Lei.;Yao Wen Zhang.;Ai Li Li.;Fu Qiang Qin.;Bei Li.;Hui Li Gao.;Ji Lin Li.;Hai Jun Yang.;Qi De Bao.;Zhi Qiang Li.;Hong Luo.;Yong Xuan Liu.;Lei Ma.;Rui Fan.;SheGan Gao.;Xin Song.;Li Dong Wang.
来源: BMC Gastroenterol. 2026年26卷1期
To compare urban-rural disparities in overall survival of patients with esophageal squamous cell carcinoma (ESCC) in China and identify independent prognostic factors.
360. Specific alterations in the gut microbiome and metabolome across disease locations of Crohn's disease: a systematic review.
作者: Jieqing Huang.;Zihan Chen.;Mengqi Chen.;Zhirong Zeng.;Xiaojun Zhuang.
来源: BMC Gastroenterol. 2026年26卷1期
Crohn's disease (CD) exhibits substantial heterogeneity in disease behavior and therapeutic outcomes across distinct disease locations. Specific alterations in the gut microbiota and metabolites may drive this variation. This review aims to characterize the distinctive microbial and metabolic signatures across CD phenotypes based on disease location.
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