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3541. POU2F2-oriented network promotes human gastric cancer metastasis.
作者: Si-Meng Wang.;Jun Tie.;Wen-Lan Wang.;Si-Jun Hu.;Ji-Peng Yin.;Xiao-Fang Yi.;Zu-Hong Tian.;Xiang-Yuan Zhang.;Meng-Bin Li.;Zeng-Shan Li.;Yong-Zhan Nie.;Kai-Chun Wu.;Dai-Ming Fan.
来源: Gut. 2016年65卷9期1427-38页
Aberrant upregulation of POU2F2 expression has been discovered in metastatic gastric cancer (GC). However, the mechanisms underlying the aberrant upregulation and the potential functions of POU2F2 remain uncertain.
3542. Prediction of oesophageal variceal bleeding by measuring spleen stiffness in patients with liver cirrhosis.
作者: Yoshitaka Takuma.;Kazuhiro Nouso.;Youichi Morimoto.;Junko Tomokuni.;Akiko Sahara.;Hiroyuki Takabatake.;Akira Doi.;Kazuhiro Matsueda.;Hiroshi Yamamoto.
来源: Gut. 2016年65卷2期354-5页 3543. Insulin resistance alters hepatic ethanol metabolism: studies in mice and children with non-alcoholic fatty liver disease.
作者: Anna Janina Engstler.;Tobias Aumiller.;Christian Degen.;Marion Dürr.;Eva Weiss.;Ina Barbara Maier.;Jörn Markus Schattenberg.;Cheng Jun Jin.;Cathrin Sellmann.;Ina Bergheim.
来源: Gut. 2016年65卷9期1564-71页
Increased fasting blood ethanol levels, suggested to stem from an increased endogenous ethanol synthesis in the GI tract, are discussed to be critical in the development of non-alcoholic fatty liver disease (NAFLD). The aim of the present study was to further delineate the mechanisms involved in the elevated blood ethanol levels found in patients with NAFLD.
3544. Serum microRNAs explain discordance of non-alcoholic fatty liver disease in monozygotic and dizygotic twins: a prospective study.
作者: Amir Zarrinpar.;Shakti Gupta.;Mano R Maurya.;Shankar Subramaniam.;Rohit Loomba.
来源: Gut. 2016年65卷9期1546-54页
In the setting where two individuals are genetically similar, epigenetic mechanisms could account for discordance in the presence or absence of non-alcoholic fatty liver disease (NAFLD). This study investigated if serum microRNAs (miRs) could explain discordance in NAFLD.
3545. Activating ERBB2/HER2 mutations indicate susceptibility to pan-HER inhibitors in Lynch and Lynch-like colorectal cancer.
作者: Michael Kloth.;Vanessa Ruesseler.;Christoph Engel.;Katharina Koenig.;Martin Peifer.;Erika Mariotti.;Helen Kuenstlinger.;Alexandra Florin.;Ursula Rommerscheidt-Fuss.;Ulrike Koitzsch.;Claudia Wodtke.;Frank Ueckeroth.;Stefanie Holzapfel.;Stefan Aretz.;Peter Propping.;Markus Loeffler.;Sabine Merkelbach-Bruse.;Margarete Odenthal.;Nicolaus Friedrichs.;Lukas Carl Heukamp.;Thomas Zander.;Reinhard Buettner.
来源: Gut. 2016年65卷8期1296-305页
Microsatellite instability (MSI) is detected in approximately 15% of all colorectal cancers (CRC) and virtually in all cases with Lynch syndrome. The MSI phenotype is caused by dysfunctional mismatch repair (MMR) and leads to accumulation of DNA replication errors. Sporadic MSI CRC often harbours BRAF(V600E); however, no consistent data exist regarding targeted treatment approaches in BRAF(wt) MSI CRC.
3546. Novel evidence for an oncogenic role of microRNA-21 in colitis-associated colorectal cancer.
作者: Chenzhang Shi.;Yongzhi Yang.;Yang Xia.;Yoshinaga Okugawa.;Jun Yang.;Yong Liang.;Hongqi Chen.;Peng Zhang.;Feng Wang.;Huazhong Han.;Wen Wu.;Renyuan Gao.;Christoph Gasche.;Huanlong Qin.;Yanlei Ma.;Ajay Goel.
来源: Gut. 2016年65卷9期1470-81页
miR-21 was found to be overexpressed in the colon tissues and serum of patients with UC and colorectal cancer (CRC); however, the exact roles of miR-21 in colitis-associated CRC remain unclear. The aim of our study was to investigate the biological mechanisms of miR-21 in colitis-associated colon cancer (CAC).
3547. Long non-coding RNA CCAL regulates colorectal cancer progression by activating Wnt/β-catenin signalling pathway via suppression of activator protein 2α.
作者: Yanlei Ma.;Yongzhi Yang.;Feng Wang.;Mary-Pat Moyer.;Qing Wei.;Peng Zhang.;Zhe Yang.;Weijie Liu.;Huizhen Zhang.;Niwei Chen.;Hua Wang.;Huamin Wang.;Huanlong Qin.
来源: Gut. 2016年65卷9期1494-504页
Long non-coding RNAs (lncRNAs) are emerging as key molecules in cancers, yet their potential molecular mechanisms are not well understood. The objective of this study is to examine the expression and functions of lncRNAs in the development of colorectal cancer (CRC).
3548. Congenital secretory diarrhoea caused by activating germline mutations in GUCY2C.
作者: Thomas Müller.;Insha Rasool.;Peter Heinz-Erian.;Eva Mildenberger.;Christian Hülstrunk.;Andreas Müller.;Laurent Michaud.;Bart G P Koot.;Antje Ballauff.;Julia Vodopiutz.;Stefan Rosipal.;Britt-Sabina Petersen.;Andre Franke.;Irene Fuchs.;Heiko Witt.;Heinz Zoller.;Andreas R Janecke.;Sandhya S Visweswariah.
来源: Gut. 2016年65卷8期1306-13页
Congenital sodium diarrhoea (CSD) refers to a form of secretory diarrhoea with intrauterine onset and high faecal losses of sodium without congenital malformations. The molecular basis for CSD remains unknown. We clinically characterised a cohort of infants with CSD and set out to identify disease-causing mutations by genome-wide genetic testing.
3549. Adolescent body mass index and erythrocyte sedimentation rate in relation to colorectal cancer risk.
作者: Elizabeth D Kantor.;Ruzan Udumyan.;Lisa B Signorello.;Edward L Giovannucci.;Scott Montgomery.;Katja Fall.
来源: Gut. 2016年65卷8期1289-95页
Adult obesity and inflammation have been associated with risk of colorectal cancer (CRC); however, less is known about how adolescent body mass index (BMI) and inflammation, as measured by erythrocyte sedimentation rate (ESR), relate to CRC risk. We sought to evaluate these associations in a cohort of 239 658 Swedish men who underwent compulsory military enlistment examinations in late adolescence (ages 16-20 years).
3550. Beyond endoscopic mucosal healing in UC: histological remission better predicts corticosteroid use and hospitalisation over 6 years of follow-up.
作者: Robert V Bryant.;Daniel C Burger.;Joseph Delo.;Alissa J Walsh.;Sally Thomas.;Axel von Herbay.;Otto C Buchel.;Lydia White.;Oliver Brain.;Satish Keshav.;Bryan F Warren.;Simon P L Travis.
来源: Gut. 2016年65卷3期408-14页
Endoscopic mucosal healing is an established treatment target for UC, yet the value of achieving histological remission remains unclear.
3551. Higher plasma motilin levels in obese patients decrease after Roux-en-Y gastric bypass surgery and regulate hunger.
作者: E Deloose.;P Janssen.;M Lannoo.;B Van der Schueren.;I Depoortere.;J Tack.
来源: Gut. 2016年65卷7期1110-8页
Motilin-induced phase III contractions of the migrating motor complex (MMC) signal hunger in healthy volunteers. The current aim was to study the role of motilin as a hunger-inducing factor in obese patients and to evaluate the effect of Roux-en-Y gastric bypass (RYGB) surgery on plasma motilin levels and hunger scores.
3552. A multicentre comparative prospective blinded analysis of EUS and MRI for screening of pancreatic cancer in high-risk individuals.
作者: F Harinck.;I C A W Konings.;I Kluijt.;J W Poley.;J E van Hooft.;H M van Dullemen.;C Y Nio.;N C Krak.;J J Hermans.;C M Aalfs.;A Wagner.;R H Sijmons.;K Biermann.;C H van Eijck.;D J Gouma.;M G W Dijkgraaf.;P Fockens.;M J Bruno.; .
来源: Gut. 2016年65卷9期1505-13页
Endoscopic ultrasonography (EUS) and MRI are promising tests to detect precursors and early-stage pancreatic ductal adenocarcinoma (PDAC) in high-risk individuals (HRIs). It is unclear which screening technique is to be preferred. We aimed to compare the efficacy of EUS and MRI in their ability to detect clinically relevant lesions in HRI.
3553. A large randomised controlled intervention trial to prevent gastric cancer by eradication of Helicobacter pylori in Linqu County, China: baseline results and factors affecting the eradication.
作者: Kai-feng Pan.;Lian Zhang.;Markus Gerhard.;Jun-ling Ma.;Wei-dong Liu.;Kurt Ulm.;Jian-xi Wang.;Lei Zhang.;Yang Zhang.;Monther Bajbouj.;Lan-fu Zhang.;Ming Li.;Michael Vieth.;Rui-yong Liu.;Michael Quante.;Le-hua Wang.;Stepan Suchanek.;Tong Zhou.;Wei-xiang Guan.;Roland Schmid.;Meinhard Classen.;Wei-cheng You.
来源: Gut. 2016年65卷1期9-18页
To clarify the full range of benefits and adverse consequences of Helicobacter pylori eradication as a strategy for gastric cancer prevention, the community-based intervention trial was launched in Linqu County, China.
3554. In oesophageal squamous cells, nitric oxide causes S-nitrosylation of Akt and blocks SOX2 (sex determining region Y-box 2) expression.
作者: Kiyotaka Asanuma.;Xiaofang Huo.;Agoston Agoston.;Xi Zhang.;Chunhua Yu.;Edaire Cheng.;Qiuyang Zhang.;Kerry B Dunbar.;Thai H Pham.;David H Wang.;Katsunori Iijima.;Tooru Shimosegawa.;Robert D Odze.;Stuart J Spechler.;Rhonda F Souza.
来源: Gut. 2016年65卷9期1416-26页
Barrett's metaplasia might develop if GORD causes oesophageal squamous cells to convert into columnar cells. Acid and bile exposures upregulate columnar differentiation genes like CDX2 in oesophageal squamous cells, but it is not known if such exposures downregulate squamous differentiation genes like SOX2. In addition to acid and bile, patients with GORD also have high oesophageal concentrations of nitric oxide (NO). This study aims to determine how acid, bile salts and NO affect genes that influence oesophageal cell phenotype.
3555. The composition and differentiation potential of the duodenal intraepithelial innate lymphocyte compartment is altered in coeliac disease.
作者: Frederike Schmitz.;Yvonne Kooy-Winkelaar.;Anna-Sophia Wiekmeijer.;Martijn H Brugman.;M Luisa Mearin.;Chris Mulder.;Susana Chuva de Sousa Lopes.;Christine L Mummery.;Frank Jt Staal.;Jeroen van Bergen.;Frits Koning.
来源: Gut. 2016年65卷8期1269-78页
Coeliac disease (CD), a gluten-induced enteropathy, alters the composition and function of duodenal intraepithelial T cells. The intestine also harbours four types of CD3-negative intraepithelial lymphocytes (IELs) with largely unknown function: CD56(-)CD127(-), CD56(-)CD127(+), CD56(+)CD127(-) and CD56(+)CD127(+). Here we aimed to gain insight into the potential function of these innate IELs in health and disease.
3556. PHLDA3 overexpression in hepatocytes by endoplasmic reticulum stress via IRE1-Xbp1s pathway expedites liver injury.
Endoplasmic reticulum (ER) stress is involved in liver injury, but molecular determinants are largely unknown. This study investigated the role of pleckstrin homology-like domain, family A, member-3 (PHLDA3), in hepatocyte death caused by ER stress and the regulatory basis.
3557. Tailored anti-TNF therapy during pregnancy in patients with IBD: maternal and fetal safety.
作者: A de Lima.;Z Zelinkova.;C van der Ent.;E A P Steegers.;C J van der Woude.
来源: Gut. 2016年65卷8期1261-8页
Antitumour necrosis factor (TNF) during pregnancy in patients with IBD is related to high fetal anti-TNF levels. We evaluated maternal and child safety on discontinuing anti-TNF in the second trimester of pregnancy.
3559. Increased expression of Solute carrier family 12 member 5 via gene amplification contributes to tumour progression and metastasis and associates with poor survival in colorectal cancer.
作者: Lixia Xu.;Xiaoxing Li.;Muyan Cai.;Jinna Chen.;Xiangchun Li.;William K K Wu.;Wei Kang.;Joanna Tong.;Ka-Fai To.;Xin-Yuan Guan.;Joseph J Y Sung.;Francis K L Chan.;Jun Yu.
来源: Gut. 2016年65卷4期635-46页
Using whole genome sequencing, we identified gene amplification of solute carrier family 12 member 5 (SLC12A5) located at 20q13.12 in colorectal cancer (CRC). We analysed its amplification, overexpression, biological effects and prognostic significance in CRC.
3560. Reliability among central readers in the evaluation of endoscopic findings from patients with Crohn's disease.
作者: Reena Khanna.;Guangyong Zou.;Geert D'Haens.;Paul Rutgeerts.;J W D McDonald.;Marco Daperno.;Brian G Feagan.;William J Sandborn.;Elena Dubcenco.;Larry Stitt.;Margaret K Vandervoort.;Allan Donner.;Allison Luo.;Barrett G Levesque.
来源: Gut. 2016年65卷7期1119-25页
The Crohn's Disease Endoscopic Index of Severity (CDEIS) and Simple Endoscopic Score for Crohn's Disease (SES-CD) are commonly used to assess Crohn's disease (CD) activity; however, neither instrument has been fully validated. We assessed intra-rater and inter-rater reliability of these indices.
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