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3502. Tissue-infiltrating neutrophils represent the main source of IL-23 in the colon of patients with IBD.
作者: Egle Kvedaraite.;Magda Lourda.;Maja Ideström.;Puran Chen.;Selma Olsson-Åkefeldt.;Marianne Forkel.;Désirée Gavhed.;Ulrik Lindforss.;Jenny Mjösberg.;Jan-Inge Henter.;Mattias Svensson.
来源: Gut. 2016年65卷10期1632-41页
In IBD, interleukin-23 (IL-23) and its receptor (IL-23R) are implicated in disease initiation and progression. Novel insight into which cells produce IL-23 at the site of inflammation at an early stage of IBD will promote the development of new tools for diagnosis, treatment and patient monitoring. We examined the cellular source of IL-23 in colon tissue of untreated newly diagnosed paediatric patients with IBD.
3503. Dual prognostic significance of tumour-associated macrophages in human pancreatic adenocarcinoma treated or untreated with chemotherapy.
作者: Giuseppe Di Caro.;Nina Cortese.;Giovanni Francesco Castino.;Fabio Grizzi.;Francesca Gavazzi.;Cristina Ridolfi.;Giovanni Capretti.;Rossana Mineri.;Jelena Todoric.;Alessandro Zerbi.;Paola Allavena.;Alberto Mantovani.;Federica Marchesi.
来源: Gut. 2016年65卷10期1710-20页
Tumour-associated macrophages (TAMs) play key roles in tumour progression. Recent evidence suggests that TAMs critically modulate the efficacy of anticancer therapies, raising the prospect of their targeting in human cancer.
3504. New Wnt/β-catenin target genes promote experimental metastasis and migration of colorectal cancer cells through different signals.
作者: Jingjing Qi.;Yong Yu.;Özlem Akilli Öztürk.;Jane D Holland.;Daniel Besser.;Johannes Fritzmann.;Annika Wulf-Goldenberg.;Klaus Eckert.;Iduna Fichtner.;Walter Birchmeier.
来源: Gut. 2016年65卷10期1690-701页
We have previously identified a 115-gene signature that characterises the metastatic potential of human primary colon cancers. The signature included the canonical Wnt target gene BAMBI, which promoted experimental metastasis in mice. Here, we identified three new direct Wnt target genes from the signature, and studied their functions in epithelial-mesenchymal transition (EMT), cell migration and experimental metastasis.
3505. Characterisation of liver pathogenesis, human immune responses and drug testing in a humanised mouse model of HCV infection.
作者: Choong Tat Keng.;Ching Wooen Sze.;Dahai Zheng.;Zhiqiang Zheng.;Kylie Su Mei Yong.;Shu Qi Tan.;Jessica Jie Ying Ong.;Sue Yee Tan.;Eva Loh.;Megha Haridas Upadya.;Chik Hong Kuick.;Hak Hotta.;Seng Gee Lim.;Thiam Chye Tan.;Kenneth T E Chang.;Wanjin Hong.;Jianzhu Chen.;Yee-Joo Tan.;Qingfeng Chen.
来源: Gut. 2016年65卷10期1744-53页
HCV infection affects millions of people worldwide, and many patients develop chronic infection leading to liver cancers. For decades, the lack of a small animal model that can recapitulate HCV infection, its immunopathogenesis and disease progression has impeded the development of an effective vaccine and therapeutics. We aim to provide a humanised mouse model for the understanding of HCV-specific human immune responses and HCV-associated disease pathologies.
3507. Ascitic fluid TREM-1 for the diagnosis of spontaneous bacterial peritonitis.
作者: L Ichou.;N Carbonell.;P E Rautou.;L Laurans.;S Bourcier.;C Pichereau.;J L Baudel.;J B Nousbaum.;C Renou.;R Anty.;J Tankovic.;E Maury.;B Guidet.;L Landraud.;H Ait-Oufella.
来源: Gut. 2016年65卷3期536-8页 3508. Genome-wide association study of gastric adenocarcinoma in Asia: a comparison of associations between cardia and non-cardia tumours.
作者: Nan Hu.;Zhaoming Wang.;Xin Song.;Lixuan Wei.;Byung Sik Kim.;Neal D Freedman.;Jiwon Baek.;Laurie Burdette.;Jiang Chang.;Charles Chung.;Sanford M Dawsey.;Ti Ding.;Yu-Tang Gao.;Carol Giffen.;Yaling Han.;Myunghee Hong.;Jia Huang.;Hee Sung Kim.;Woon-Puay Koh.;Linda M Liao.;Yi Min Mao.;You-Lin Qiao.;Xiao-Ou Shu.;Wen Tan.;Chaoyu Wang.;Chen Wu.;Min-Jie Wu.;Yong-Bing Xiang.;Meredith Yeager.;Jeong Hwan Yook.;Jian-Min Yuan.;Peng Zhang.;Xue-Ke Zhao.;Wei Zheng.;Kyuyoung Song.;Li-Dong Wang.;Dongxin Lin.;Stephen J Chanock.;Alisa M Goldstein.;Philip R Taylor.;Christian C Abnet.
来源: Gut. 2016年65卷10期1611-8页
Genome-wide association studies (GWAS) of gastric cancer have reported differences in single-nucleotide polymorphism (SNP) associations for tumour subtypes, particularly when divided by location into the gastric cardia versus the non-cardia.
3509. Tablet computer-based multimedia enhanced medical training improves performance in gastroenterology and endoscopy board style exam compared with traditional medical education.3511. Length of Barrett's oesophagus and cancer risk: implications from a large sample of patients with early oesophageal adenocarcinoma.
作者: Heiko Pohl.;Oliver Pech.;Haris Arash.;Manfred Stolte.;Hendrik Manner.;Andrea May.;Klaus Kraywinkel.;Amnon Sonnenberg.;Christian Ell.
来源: Gut. 2016年65卷2期196-201页
Although it is well understood that the risk of oesophageal adenocarcinoma increases with Barrett length, transition risks for cancer associated with different Barrett lengths are unknown. We aimed to estimate annual cancer transition rates for patients with long-segment (≥3 cm), short-segment (≥1 to <3 cm) and ultra-short-segment (<1 cm) Barrett's oesophagus.
3513. The gamma-glutamyl transpeptidase to platelet ratio (GPR) predicts significant liver fibrosis and cirrhosis in patients with chronic HBV infection in West Africa.
作者: Maud Lemoine.;Yusuke Shimakawa.;Shevanthi Nayagam.;Mustapha Khalil.;Penda Suso.;Jo Lloyd.;Robert Goldin.;Harr-Freeya Njai.;Gibril Ndow.;Makie Taal.;Graham Cooke.;Umberto D'Alessandro.;Muriel Vray.;Papa Saliou Mbaye.;Ramou Njie.;Vincent Mallet.;Mark Thursz.
来源: Gut. 2016年65卷8期1369-76页
Simple and inexpensive non-invasive fibrosis tests are highly needed but have been poorly studied in sub-Saharan Africa.
3514. Derivation of genetic biomarkers for cancer risk stratification in Barrett's oesophagus: a prospective cohort study.
作者: Margriet R Timmer.;Pierre Martinez.;Chiu T Lau.;Wytske M Westra.;Silvia Calpe.;Agnieszka M Rygiel.;Wilda D Rosmolen.;Sybren L Meijer.;Fiebo J W Ten Kate.;Marcel G W Dijkgraaf.;Rosalie C Mallant-Hent.;Anton H J Naber.;Arnoud H A M van Oijen.;Lubbertus C Baak.;Pieter Scholten.;Clarisse J M Böhmer.;Paul Fockens.;Carlo C Maley.;Trevor A Graham.;Jacques J G H M Bergman.;Kausilia K Krishnadath.
来源: Gut. 2016年65卷10期1602-10页
The risk of developing adenocarcinoma in non-dysplastic Barrett's oesophagus is low and difficult to predict. Accurate tools for risk stratification are needed to increase the efficiency of surveillance. We aimed to develop a prediction model for progression using clinical variables and genetic markers.
3515. Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology.
作者: Maria Carlota Dao.;Amandine Everard.;Judith Aron-Wisnewsky.;Nataliya Sokolovska.;Edi Prifti.;Eric O Verger.;Brandon D Kayser.;Florence Levenez.;Julien Chilloux.;Lesley Hoyles.; .;Marc-Emmanuel Dumas.;Salwa W Rizkalla.;Joel Doré.;Patrice D Cani.;Karine Clément.
来源: Gut. 2016年65卷3期426-36页
Individuals with obesity and type 2 diabetes differ from lean and healthy individuals in their abundance of certain gut microbial species and microbial gene richness. Abundance of Akkermansia muciniphila, a mucin-degrading bacterium, has been inversely associated with body fat mass and glucose intolerance in mice, but more evidence is needed in humans. The impact of diet and weight loss on this bacterial species is unknown. Our objective was to evaluate the association between faecal A. muciniphila abundance, faecal microbiome gene richness, diet, host characteristics, and their changes after calorie restriction (CR).
3517. The broad assessment of HCV genotypes 1 and 3 antigenic targets reveals limited cross-reactivity with implications for vaccine design.
作者: Annette von Delft.;Isla S Humphreys.;Anthony Brown.;Katja Pfafferott.;Michaela Lucas.;Paul Klenerman.;Georg M Lauer.;Andrea L Cox.;Silvana Gaudieri.;Eleanor Barnes.
来源: Gut. 2016年65卷1期112-23页
Developing a vaccine that is cross-reactive between HCV genotypes requires data on T cell antigenic targets that extends beyond genotype-1. We characterised T cell immune responses against HCV genotype-3, the most common infecting genotype in the UK and Asia, and assessed within genotype and between genotype cross-reactivity.
3518. Clinical profiles and outcomes in idiopathic duct-centric chronic pancreatitis (type 2 autoimmune pancreatitis): the Mayo Clinic experience.
作者: Phil A Hart.;Michael J Levy.;Thomas C Smyrk.;Naoki Takahashi.;Barham K Abu Dayyeh.;Jonathan E Clain.;Ferga C Gleeson.;Randall K Pearson.;Bret T Petersen.;Mark D Topazian.;Santhi S Vege.;Lizhi Zhang.;Suresh T Chari.
来源: Gut. 2016年65卷10期1702-9页
Idiopathic duct-centric chronic pancreatitis (IDCP), also known as type 2 autoimmune pancreatitis (AIP), is an uncommon subtype of AIP. International Consensus Diagnostic Criteria for IDCP propose that the diagnosis requires pancreatic histology and/or concurrent IBD. We examined our experience with IDCP (type 2 AIP) to assess the appropriateness of these criteria, and identify unique characteristics in patients presenting with acute pancreatitis.
3520. Ribavirin restores IFNα responsiveness in HCV-infected livers by epigenetic remodelling at interferon stimulated genes.
作者: Barbara Testoni.;David Durantel.;Fanny Lebossé.;Judith Fresquet.;François Helle.;Francesco Negro.;Maria Francesca Donato.;Massimo Levrero.;Fabien Zoulim.
来源: Gut. 2016年65卷4期672-82页
Caveats in the understanding of ribavirin (RBV) mechanisms of action has somehow prevented the development of better analogues able to further improve its therapeutic contribution in interferon (IFN)-based and direct antiviral agent-based regimens for chronic HCV or other indications. Here, we describe a new mechanism by which RBV modulates IFN-stimulated genes (ISGs) and contributes to restore hepatic immune responsiveness.
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