To evaluate the technical feasibility, targeting accuracy and short-term safety of a novel integrated system of the robot-navigated, cone-beam CT (CBCT)-guided and transarterial chemoembolization (TACE)-assisted radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) in high-risk locations.

The association between metabolic vulnerability index (MVX), a composite biomarker integrating inflammatory and metabolic pathways, and chronic liver diseases (CLDs) is still unclear.

Gallstone disease is a common clinical condition worldwide, with a global incidence ranging from less than 10% to over 40% and affecting approximately 3-11% of the population in China. This high and increasing prevalence places a significant burden on healthcare resources due to the costs associated with diagnosis, treatment, and long-term follow-up. More importantly, gallstones can lead to severe complications, such as acute cholecystitis, cholangitis, and pancreatitis, establishing the disease as a major public health concern. Although traditionally associated with a higher incidence in middle-aged women, the number of elderly patients with gallstones is rising as Chinese society ages. However, large-scale epidemiological studies covering the entire adult age spectrum and explicitly exploring the relationship between age and gallstone incidence remain scarce. Furthermore, while numerous studies have investigated risk factors for gallstone formation, few have examined the dynamic changes in individual-level data before and after stone formation-an approach that could offer more valuable insights for personalized prevention. Therefore, this study aims to address these gaps through a retrospective analysis of 10 years of health examination data, to explore the incidence trend and preventable risk factors for gallstones, and ultimately to provide a basis for improving clinical management and prevention strategies.

Hepatoid adenocarcinoma of the stomach (HAS) is a rare form of gastric cancer. This study assessed the impact of tumor node metastasis (TNM) stage on survival in HAS compared with non-HAS patients, identified prognostic factors, and developed a predictive nomogram.

This study was designed to evaluate differences in mortality, complication rates, and length of hospital stay between early (≤ 4 weeks) and delayed (> 4 weeks) minimally invasive drainage in patients with necrotizing pancreatitis (NP) through the synthesis of existing evidence.

Neoadjuvant chemotherapy (NAC) and neoadjuvant chemoradiotherapy (nCRT) are increasingly used to treat adenocarcinoma of the esophagogastric junction (AEG). However, there is insufficient clinical evidence to compare surgical safety among the three comprehensive treatment models, including the surgery‑first model, NAC model, and nCRT model. Therefore, this study was designed to compare surgical safety of the three comprehensive treatment models.

A Clutch Cutter is a grasping scissor forceps device used for endoscopic submucosal dissection (ESD). This device can grasp and incise the target tissue similar to the action of a biopsy forceps. Therefore, ESD with a Clutch Cutter may be easier and safer than that performed with non-scissor-type knives. This study verified the usefulness of the Clutch Cutter by nonexpert endoscopists during ESD for superficial esophageal cancer.

The global incidence of early-onset colorectal cancer (EOCRC) is increasing. The prognostic impact of EOCRC remains controversial, as it is largely confounded by hereditary syndromes and mismatch repair deficient (dMMR)/microsatellite instability-high (MSI-H) tumors. We aimed to evaluate the clinicopathological features and stage-adjusted outcomes of sporadic, proficient MMR/microsatellite stable (pMMR/MSS) EOCRC.

Interventional therapies and systemic chemotherapy are the mainstay of treatment for patients with unresectable hepatocellular carcinoma (HCC). This study aimed to generate preliminary evidence regarding the feasibility and safety of transarterial chemoembolization (TACE) combined with hepatic artery infusion chemotherapy (HAIC), targeted therapy, and immunotherapy in patients with unresectable hepatocellular carcinoma (HCC).

Mortality for severe acute cholangitis is significantly reduced after endoscopic biliary drainage. Our institution has utilized endoscopic retrograde cholangiopancreatography (ERCP) without fluoroscopy in the intensive care unit (ICU), termed Biliary Endoscopic Drainage of Septic ICU patients Deemed Emergent (BEDSIDE) ERCP, in rare circumstances for critically ill patients with severe acute cholangitis where timely conventional ERCP was not available and delayed biliary drainage could adversely affect clinical outcomes. The objective of this study is to describe the BEDSIDE technique and its feasibility to provide expedited biliary drainage in critically ill patients in the ICU with severe acute cholangitis where timely conventional ERCP was not available.

Ulcerative colitis (UC) is a chronic inflammatory bowel disease marked by relapsing mucosal inflammation. Recent data indicate that subclinical metabolic disturbances persist even in patients who have achieved remission. However, the temporal evolution of these molecular alterations remains poorly defined. This study examined how disease duration shapes systemic metabolic and lipidomic remodeling in UC.

Abdominal fat area has been reported to be associated with early recurrence (ER) after surgical resection of hepatocellular carcinoma (HCC). This study aimed to compare the predictive value of abdominal fat area and volume for ER after resection of HCC.

Sufficient cleansing of the colonic mucosa is of great importance during colonoscopy emphasizing the need for effective preparation agents. Studies evaluating the efficacy of a novel 1 L polyethylene glycol with ascorbate (1 L-PEG-Asc), Plenvu®, versus standard 2 L polyethylene glycol with ascorbate (2 L-PEG-Asc), Moviprep®, have shown promising results regarding bowel cleansing. Nonetheless superiority of 1 L-PEG-Asc has not been shown.

Acute pancreatitis lacks reliable early predictors of disease severity. Serum phosphate has been shown to be associated with the severity and mortality of acute pancreatitis, but its utility is uncertain.

Fecal microbiota transplantation (FMT) could improve symptoms of irritable bowel syndrome (IBS) in some previous trials. We updated a prior meta-analysis of randomized controlled trials (RCTs) determining this issue.