As a rare subtype of primary liver cancer that contains both hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) components, combined hepatocellular carcinoma-cholangiocarcinoma (cHCC-CCA) is characterized by strong invasiveness and poor prognosis. The proportion of HCC and CCA components is closely related to the prognosis of patients. This study aimed to develop a combined model integrating preoperative ultrasound radiomic features and clinical data to non-invasively predict the predominant component in cHCC-CCA.

Early detection of gastric cancer (GC) is crucial for improving prognosis. This study aimed to address the paucity of longitudinal evidence by validating and comparing the long-term predictive efficacy of the serology-based Li's scoring system and the endoscopic Kyoto classification for GC risk stratification in a Chinese population.

This study aimed to investigate the necessity and safety of routinely placing prophylactic hemoclips at the duodenal papilla during endoscopic retrograde cholangiopancreatography to prevent delayed bleeding.

Hepatitis B virus (HBV) infection poses a significant public health challenge, leading to liver cirrhosis and hepatocellular carcinoma (HCC). The clinical course of HBV infection is influenced by viral, environmental, and host genetic variants. Recently, a Cirrhosis Risk Score (CRS) based on seven genetic variants has been developed to identify individuals at risk of developing cirrhosis. This study aimed to assess the predictive value of seven gene signatures in Egyptian patients with HBV infection as molecular biomarkers for cirrhosis.

Hemangioma most commonly occurs in the head and neck, rarely affects the digestive tract, and often presents without any clinical signs. The treatment of esophageal hemangioma has been widely reported internationally. However, reports on the sole application of endoscopic band ligation for the treatment of esophageal hemangioma are relatively rare.

Benign gallbladder disease, including gallstones, gallbladder polyps, and gallbladder adenomyosis, is one of the most common disorders of the digestive system worldwide and poses a substantial clinical and economic burden. Despite its high prevalence, the clinical characteristics and risk profiles of hospitalized patients with benign gallbladder disease are not well defined, especially compared with population-based screening cohorts. This study aimed to analyze the clinical characteristics of hospitalized patients with benign gallbladder disease using a large dataset and to compare these findings with those reported in physical examination populations.

Our study aimed to compare remimazolam, midazolam, and no sedative on postoperative delirium (POD) incidence, cognitive function, inflammation, and recovery in elderly colorectal cancer (CRC) laparoscopic radical resection patients.

One of serious side effects of liver cirrhosis is spontaneous bacterial peritonitis (SBP), which is defined by existence of infected ascites without a discernible secondary source of infection. One possible mechanism for development of SBP is microbial translocation.

The coexistence of metabolic dysfunction-associated steatotic liver disease (MASLD) and chronic hepatitis B (CHB) may influence liver fibrosis, but the relationship between these conditions remains unclear. MASLD may also affect the performance of non-invasive tests (NITs) in CHB. Recently developed NITs, such as FIB-8 and FIB-9, were designed for MASLD patients but have not been assessed in those with both CHB and MASLD. This study aimed to comparatively assess the diagnostic performance of various NITs for predicting significant fibrosis in CHB patients stratified by MASLD status.

The cause of Crohn's disease (CD) remains unclear; however, evidence suggests fiber intake may play a role. We aimed to investigate the association between intake of total fiber and select fermentable fiber subtypes and future risk of CD in an at-risk population.

Inflammatory bowel disease (IBD) has shown a steadily rising prevalence in Asian populations over recent decades, coinciding with rapid industrialization, Westernized dietary habits, and lifestyle changes. This study aimed to report the annual trends and sociodemographic-specific rates of the prevalence and incidence of diagnosed IBD in Taiwan from 2011 to 2021.

Patient-centered care (PCC) and shared decision-making (SDM) are internationally recognized as the preferred approaches to patient care. However, implementation in daily clinical practice remains challenging as sustainable behavioral change requires a multifaceted approach. We developed and evaluated a training program consisting of an e-learning, skills training, deliberate practice and a group reflection session, aimed at improving gastroenterologists' patient-centered attitudes and SDM skills.

Liver hepatocellular carcinoma (LIHC) is a leading cause of cancer-related mortality worldwide, with limited therapeutic options and poor prognosis, particularly at advanced stages. Identifying key molecular drivers involved in LIHC progression is critical for improving diagnosis and treatment strategies. In this study, we performed an integrated bioinformatics analysis using four independent GEO datasets (GSE19665, GSE54236, GSE55092, and GSE84598) to identify differentially expressed genes (DEGs) associated with LIHC. A total of 147 common DEGs were identified, and protein-protein interaction network analysis revealed CCNA2, MAD2L1, AURKA, and PTTG1 as central hub genes. Functional enrichment analyses indicated that these genes are primarily involved in cell cycle regulation, mitosis, and chromosomal stability. Expression analyses using TCGA-based databases demonstrated significant upregulation of these hub genes at both mRNA and protein levels in LIHC tissues compared with normal liver tissues. Elevated expression was associated with advanced tumor stage, poor overall survival, immune cell infiltration, and altered drug sensitivity, highlighting their clinical relevance. Promoter methylation analysis suggested that epigenetic regulation may contribute to gene dysregulation, while genetic alterations were infrequent. Experimental validation using RT-qPCR confirmed overexpression of hub genes in LIHC cell lines. Furthermore, siRNA-mediated knockdown of these genes significantly suppressed proliferation, colony formation, and migration in HepG2 and Huh7 cells. Collectively, these findings identify CCNA2, MAD2L1, AURKA, and PTTG1 as key oncogenic drivers and potential biomarkers and therapeutic targets in LIHC.

Angiotensin-converting enzyme (ACE) inhibitor-induced intestinal angioedema is a rare but clinically significant adverse drug reaction. Isolated visceral involvement, occurring without the cutaneous, oropharyngeal, or laryngeal manifestations classically associated with ACE inhibitor angioedema, is particularly under-recognised and is repeatedly mistaken for common gastrointestinal disorders. Most reported cases describe symptom onset within hours to days of initiation; cases with subacute onset over several weeks-mimicking a functional bowel disorder-are far less well characterised.