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242. Dual GIP/GLP-1 receptor agonist tirzepatide ameliorates hepatic steatosis and inflammatory responses in a MASLD mouse model associated with the CCL2/CCR2 axis.
作者: Yongning Pan.;Fanfan Song.;Xuehua Liu.;Yan Zhang.;Juanjuan Zhang.;Guangyao Song.;Luping Ren.
来源: BMC Gastroenterol. 2026年26卷1期
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a common multisystem chronic progressive liver disease with a rising burden. Tirzepatide (TZP), a dual agonist of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors, has shown beneficial hepatic effects, but the related molecular mechanisms remain unclear. The aim of this study was to investigate the hepatic molecular signatures associated with TZP in MASLD.
243. Training satisfaction, competency gaps and well-being in gastroenterology residency in Spain: results of a national SEPD survey.
作者: Marisa Iborra.;María Dolores Martín-Arranz.;Judith Gómez-Camarero.;Rafael Gómez-Rodríguez.;Julio Iglesias-Garcia.;Aitor Orive-Calzada.;Luis Téllez.;Federico Argüelles-Arias.
来源: BMC Gastroenterol. 2026年26卷1期
To explore the training experience, competency needs and professional wellbeing of Gastroenterology trainees in Spain, with a particular focus on factors associated with burnout.
244. Association of red blood cell distribution width to albumin ratio with all-cause and cardiovascular mortality among adults with MASLD.
作者: Ze-Bin Ni.;Lian-Zhen Huang.;Qi-Rong Yao.;Qian Li.;Ji Li.;Wei-Feng Huang.;Jin-Yan Zhang.;Yan-Qing Wang.
来源: BMC Gastroenterol. 2026年26卷1期
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing global health burden. Identifying robust prognostic biomarkers is crucial for early risk stratification. The red blood cell distribution width to albumin ratio (RAR) has emerged as a potential biomarker reflecting inflammation and nutritional status. This study aimed to evaluate the association between RAR and both all-cause and cardiovascular mortality among adults with MASLD.
245. Post-splenectomy early biochemical trajectories and predictors in 935 patients with Wilson disease: a group-based trajectory modeling study.
作者: Xiuquan Shi.;Sihuan Zhu.;Ning Sang.;Lei Jin.;Hui Peng.;Jie Chen.;Qingsheng Yu.
来源: BMC Gastroenterol. 2026年26卷1期
Splenectomy is commonly used to alleviate portal hypertension-related hypersplenism in patients with Wilson's disease (WD) cirrhosis. However, early post-splenectomy biochemical responses vary substantially among individuals, and objective tools to characterize these dynamic patterns remain limited. This study aimed to identify early postoperative biochemical trajectories after splenectomy in patients with WD and to determine preoperative factors associated with unfavorable trajectory patterns.
246. Risk factors for residual cancer and lymph node metastasis after non-curative endoscopic resection of colorectal cancer: a multicenter retrospective study.
作者: Soo Young Oh.;Hyung-Hoon Oh.;Young Il Kim.;Dong-Hyun Kim.;Young-Eun Joo.;Hyun-Soo Kim.;Won-Kyung Kang.;Jong Lyul Lee.;Yong Sik Yoon.;Chan Wook Kim.;In Ja Park.;Seok-Byung Lim.
来源: BMC Gastroenterol. 2026年26卷1期
Following a non-curative endoscopic resection of T1 colorectal cancer, current guidelines recommend additional surgery based on high-risk pathological features. However, the actual rates of residual disease, such as residual cancer and lymph node metastasis (LNM), remain unclear and risk factors vary significantly across studies. We aimed to determine the true incidence of residual cancer and LNM and identify independent risk factors to guide surgical decision-making.
247. Construction and validation of a machine learning-based prediction model for social isolation in patients with colorectal cancer after stoma surgery.
To investigate the current status and influencing factors of social alienation in patients with enterostomy after colorectal cancer surgery, and to establish a risk prediction model for social alienation in this population.
248. A linear clinical prediction model and nomogram evaluating risk of portal vein thrombosis in liver cirrhosis.
As one of the complications of liver cirrhosis, portal vein thrombosis (PVT) brings a significant clinical challenge. To find the predictive clinical variables evaluating the probability of PVT, a prediction model was established and a nomogram was built for visualization.
249. Association of a novel Fat-Muscle-BMI Index (FMBI) with NAFLD, liver fibrosis, and atherosclerotic cardiovascular disease risk: a cross-sectional study in 1,592 Chinese adults.
作者: Xiaokang Wu.;Xinjiang Hou.;Jiafeng Yin.;Yue Li.;Chaoliang Xiong.;Hailong Liu.;Hao Meng.
来源: BMC Gastroenterol. 2026年26卷1期
Non-alcoholic fatty liver disease (NAFLD) is a global burden with unmet non-invasive biomarker needs; BMI and FMRs have limitations, and their combined index FMBI is unstudied. We aim to explore FMBI's association with NAFLD, associated liver fibrosis and atherosclerotic cardiovascular disease risk (ASCVD) risk.
250. ETV4 as a potential target gene for alleviating proliferation metastasis of HCC.
作者: Yuan Yuan.;Qinglin Tan.;Maolin Zhu.;Long Chen.;Di Sun.;Yun Liang.
来源: BMC Gastroenterol. 2026年26卷1期
Hepatocellular carcinoma (HCC) develops and progresses via the RAF/MERK/ERK signaling pathway. Sorafenib, a first-line therapy for advanced HCC, inhibits the RAF gene. However, RAF dimerization and ERK activation caused by RAF inhibition in HCC, and this paradoxical RAF/MERK/ERK activation is one of the reasons for Sorafenib resistance in liver cell carcinoma. ETV4 is an ERK downstream gene, hence inhibiting it may help to reduce treatment resistance in HCC. The human hepatoma cell line HepG2.2.15 was used as an HCC tumor cell model, while the HL-7702 cell line was used as a human normal hepatocytes cell model. In order to find out the function of ETV4, Small interfering RNA (siRNA) was used to knock down ETV4 gene. Experiments on cell phenotype and function were performed to test the effects of knocking down ETV4.
251. Fusobacterium nucleatum exacerbates chronic atrophic gastritis in rats via mitochondrial dysfunction and inflammatory activation.
作者: Peixun Zhao.;Yiyang Fan.;Haohan Liu.;Yue Jin.;Yizinaer Abula.;Adili Abudourousuli.;Yangyang Zhang.
来源: BMC Gastroenterol. 2026年26卷1期
Chronic atrophic gastritis (CAG) is a premalignant condition with limited therapeutic strategies. The role of the oral pathogen Fusobacterium nucleatum (F. nucleatum), associated with gastrointestinal carcinogenesis, in CAG remains unclear.
252. Applications of machine learning in the diagnosis of non-alcoholic fatty liver disease: a systematic review and meta-analysis.
作者: Luying Qi.;Baiwang Li.;Jingnan Xue.;Xiangpeng Wu.;Hupo Bian.;Jieqiong Chen.;Hongxing Zhao.
来源: BMC Gastroenterol. 2026年26卷1期
To systematically evaluate and quantify the diagnostic accuracy and performance of machine ML techniques for the detection of NAFLD, and to compare the performance of ML when assisting different diagnostic modalities, in order to provide the promising strategy for non-invasive and accurate diagnosis of NAFLD.
253. Early warning value of serum TFF3 combined with pepsinogen ratio for monitoring the progression of gastric precancerous lesions: a retrospective study.
Gastric cancer (GC) has high mortality due to late diagnosis. Identifying which patients with gastric low-grade intraepithelial neoplasia (LGIN) will progress to high-grade intraepithelial neoplasia (HGIN) or early gastric cancer (EGC) remains challenging. This study aimed to develop a non-invasive method combining serum TFF3 (reflecting malignant transformation) and pepsinogen ratio (PGR, indicating gastric atrophy) to predict progression.
254. Bifidobacterium breve207-1 protects against later-life colitis following early-life antibiotic exposure by enhancing intestinal barrier and immune homeostasis.
作者: Xiaolin Xu.;Liang Li.;Xiaoting Li.;Yunyi Wang.;Minghao Huang.;Huajiao Wu.;Huijing Liang.;Xiaolei Ze.;Fang He.;Xi Shen.
来源: BMC Gastroenterol. 2026年26卷1期
The early colonization of bacteria has a significant impact on immune system development. The disruption of gut microbiota by antibiotics in early life is a major risk factor for pediatric inflammatory bowel disease. This study explores how Bifidobacterium breve 207-1 modulates gut microbiota and immune responses after early antibiotic exposure, and whether such intervention mitigates DSS-induced colitis later in life.
255. Selenoprotein P deficiency in MASLD: association with insulin resistance and liver fibrosis: a prospective case-control study.
作者: Mona A Hegazy.;Samar Saad Mohamed.;Eman H Saad.;Ahmed Abdelghani.;Dalia Abd El Fattah.;Mohamed Ahmed Elsayed Mekki.;Mona Fathy.;Nora Hassan.;Omar Ashoush.
来源: BMC Gastroenterol. 2026年26卷1期
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a globally escalating health concern. Selenoprotein P (SEPP1) is a hepatokine involved in selenium transport and antioxidant defense, with conflicting data on its role in MASLD. This study investigated serum SEPP1 as a potential non-invasive biomarker for disease severity and fibrosis staging.
256. Pathology-Driven Epithelial Sulfide Loss Reprograms the Redox Proteome and Triggers Barrett's Esophagus.
作者: Edyta Korbut.;Mateusz Wierdak.;Thibaut Vignane.;Dominik Bakalarz.;Katarzyna Magierowska.;Maciej Suski.;Vincent T Janmaat.;Jerzy Hankus.;Urszula Glowacka.;Malgorzata Farbaniec.;Dagmara Wójcik-Grzybek.;Matthew Whiteman.;Michał Kukla.;Ron Smits.;Rhonda F Souza.;Milos R Filipovic.;Marcin Magierowski.
来源: Gastroenterology. 2026年
Barrett's esophagus (BE), a metaplastic transformation driven by gastroesophageal reflux disease (GERD), induces oxidative stress but the underlying redox mechanisms remain poorly understood. Protein persulfidation (PSSH), a redox-sensitive, reversible, and antioxidative post-translational modification regulated by hydrogen sulfide (H2S) metabolism, has not been explored in this context. Here, we identify epithelial PSSH as a key regulator of this premalignant process.
257. Transjugular intrahepatic portosystemic shunt for hepatic sinusoidal obstruction syndrome induced by pyrrolizidine alkaloid.
作者: Tan-Yang Zhou.;Kun Ji.;Guo-Fang Tao.;Hong-Liang Wang.;Tong-Yin Zhu.;Sheng-Qun Chen.;Yue-Lin Zhang.;Guan-Hui Zhou.;Bao-Quan Wang.;Shou-Jin Cao.;Kai-Bing Wang.;Li Jing.;Bin Xiong.
来源: BMC Gastroenterol. 2026年26卷1期
To evaluate the efficacy and outcomes of transjugular intrahepatic portosystemic shunt (TIPS) in treating pyrrolizidine alkaloid-induced hepatic sinusoidal obstruction syndrome (PA-HSOS).
258. A simple scoring system to estimate adenoma detection rate from polyp detection: a two-center observational study.
作者: Zhiyu Dong.;Yanglei Li.;Zili Xiao.;Feng Li.;Shuchang Xu.;Danian Ji.
来源: BMC Gastroenterol. 2026年26卷1期
The calculation of adenoma detection rate (ADR) requires pathological information, which makes it time-consuming. We aimed to develop a scoring system to estimate ADR from polyp detection accurately.
259. An unusual superior mesenteric arteriovenous malformation causing obscure gastrointestinal bleeding: a case report.
作者: Mohammad Alashqar.;Mohammed I Abu Kamesh.;Raneem Alsadi.;Mohammed Khader.;Hala Qasrawi.
来源: BMC Gastroenterol. 2026年26卷1期
Lower gastrointestinal bleeding (LGIB) frequently presents a diagnostic challenge, particularly in liver cirrhosis and portal hypertension patients, as it accounts for about 20-25% of major gastrointestinal bleeding cases. The presence of multiple possible sources of bleeding, among which vascular abnormalities, increases the risk of recurrent bleeding, and clinically significant anemia. Mesenteric arteriovenous malformations (AVMs) are one of the rare high-flow vascular lesions that may lead to gastrointestinal bleeding through arterial blood being diverted to the veins and venous hypertension. As the findings of an endoscopic examination can be unclear, cross-sectional angiographic imaging is indispensable for diagnosis and treatment planning.
260. Pneumatosis cystoides intestinalis mimicking colonic subepithelial tumors with spontaneous resolution after relocation from a high-altitude region: a case report.
Pneumatosis cystoides intestinalis(PCI) is a relatively rare condition with a pathogenesis that remains incompletely understood. It is typically managed through conservative medical treatment, with surgical intervention considered when necessary. We report a case of PCI in which the lesions resolved spontaneously after diagnostic endoscopic submucosal dissection (ESD).
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