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221. Preoperative and perioperative predictors of prolonged hospital stay after uncomplicated elective laparoscopic cholecystectomy: a retrospective cohort study.
作者: Ramazan Topcu.;Turker Kaymak.;Mahmut Arif Yüksek.;Orhan Aslan.;Elif Yiğit Kaymak.;İsmail Sezikli.;Kaan Canal.;Aşkın Kadir Perçem.
来源: BMC Gastroenterol. 2026年
Although laparoscopic cholecystectomy is considered the gold standard for benign gallbladder disease and is typically associated with short hospitalization, a subset of patients experience prolonged length of stay (LOS), increasing healthcare costs and resource utilization. Early identification of patients at risk for extended hospitalization may facilitate perioperative optimization and discharge planning. This study aimed to identify perioperative predictors of prolonged hospital stay following uncomplicated elective laparoscopic cholecystectomy and to evaluate the discriminative performance of a multivariable predictive model.
222. Changing etiological spectrum of cirrhosis in China: a systematic review and meta-analysis.
作者: Cong He.;Pengcheng Liu.;Xiaoxiang Liu.;Pingping Cai.;Xinbo Fu.;Jian Li.
来源: BMC Gastroenterol. 2026年
Cirrhosis remains a major public health challenge in China and has historically been driven mainly by chronic viral hepatitis. However, alcohol-related liver disease and metabolic liver disease have received increasing attention in recent decades. Changes in hepatitis B vaccination, antiviral therapy, blood safety, alcohol consumption, and metabolic risk factors may have altered the reported etiological profile of cirrhosis. Existing evidence remains largely region-specific, hospital-based, or limited to particular time periods. This systematic review and meta-analysis aimed to characterize the reported etiological spectrum of cirrhosis in mainland China and to describe temporal and regional patterns.
223. Effectiveness and safety of vedolizumab in real-world studies in Asian patients with inflammatory bowel disease: a systematic review and meta-analysis.
To evaluate the real-world effectiveness and safety of vedolizumab (VDZ) in Asian patients with IBD, including Crohn's disease (CD) and Ulcerative colitis (UC).
224. Associations of bilirubin, albumin, and the ALBI index with gastric cancer risk: a smoking-stratified prospective cohort study in men.
Bilirubin and albumin are endogenous antioxidants, and the ALBI index may reflect systemic oxidative stress. However, their associations with gastric cancer risk, especially by smoking status in healthy populations, remain unclear.
225. Use of medications to treat inflammatory bowel diseases before and during pregnancy in Switzerland between 2012 and 2019: an observational study using the claims-based MAMA cohort.
作者: Eva Gerbier.;Nazanin Abolhassani.;Marc Dupuis.;Byron Oppliger.;Sreemanjari Kandhasamy.;Guillaume Favre.;Emeline Maisonneuve.;Ursula Winterfeld.;Hélène Legardeur.;Michael Ceulemans.;David Baud.;Julia Spoendlin.;Alice Panchaud.
来源: BMC Gastroenterol. 2026年
Effective management of Inflammatory bowel diseases (IBD) before and during pregnancy is crucial as women with well-controlled IBD at conception tend to remain in remission throughout pregnancy, experiencing outcomes similar to women without IBD. Most IBD medications are considered safe during pregnancy, except for methotrexate. Despite reassuring data, previous studies have highlighted that women often have negative perceptions and fears related to IBD medications, leading to poor adherence. There is a lack of data regarding how IBD is treated before and during pregnancy in Switzerland. We aimed to assess the prevalence and usage patterns of various IBD medications in Switzerland before and during pregnancy over time.
228. The influence of self-care-related constructs on medication adherence in inflammatory bowel disease: a scoping review.
作者: Piergiorgio Martella.;Elisa Schiavoni.;Daniele Napolitano.;Antonello Cocchieri.
来源: Minerva Gastroenterol (Torino). 2026年
Self-care is increasingly recognized as a key determinant of outcomes in inflammatory bowel disease (IBD), yet its relationship with medication adherence remains inconsistently mapped. This scoping review aimed to explore how self-care-related constructs, including self-efficacy and patient activation are associated with medication adherence.
229. Machine learning models to predict the recurrence of common bile duct stones after ERCP.
To construct predictive models for the recurrence of common bile duct stones (CBDS) following endoscopic retrograde cholangiopancreatography (ERCP).
230. TACE, lenvatinib, and PD-1 inhibitors in unresectable advanced hepatocellular carcinoma: an exploratory retrospective cohort study.
For patients with unresectable advanced hepatocellular carcinoma (HCC), therapeutic options are limited, and transarterial chemoembolization (TACE) alone often yields suboptimal outcomes. This study aimed to evaluate clinical outcomes and recorded safety events associated with combining TACE, lenvatinib, and programmed cell death protein 1 (PD-1) inhibitors for HCC.
231. Outcomes for a digital prescription mobile application for adults with irritable bowel syndrome: an uncontrolled trial.
作者: Mohsin F Butt.;Maiss Reghefaoui.;Debbie Bush.;Abdulsalam Aliyu.;Ana-Maria Darie.;Aleesha Mohanan.;Alice Sibelli.;Timothy R Card.;Maura Corsetti.
来源: BMC Gastroenterol. 2026年26卷1期
Behavioral therapies are effective in the management of irritable bowel syndrome (IBS). Mahana™ IBS is a mobile phone application designed to deliver 10 sessions (10-12 weeks) of gut-directed cognitive behavioral therapy (CBT) to adults with IBS.
232. Distal Recirculation of Enteral contents Augmented Mechanically (DREAM) Promotes Intestinal Adaptation and Restores Enterohepatic Signaling in Short Bowel Syndrome.
作者: Shaurya Mehta.;Kento Kurashima.;Chandrashekhara Manithody.;Takahiro Ohkura.;Sylvia Morfin.;Ashlesha Bagwe.;Marzena Syn.;Austin Sims.;Sree Kolli.;Connor Whalen.;Aditya Jain.;Miguel Guzman.;Sherri Besmer.;Sonali Jain.;Paula Buchanan.;Keith Pereira.;Chien-Jung Lin.;Bolette Hartmann.;Jens J Holst.;John Long.;Shin Miyata.;Matthew McHale.;Chelsea Hutchinson.;Ajay Kumar Jain.
来源: Gastroenterology. 2026年
Short bowel syndrome (SBS) leads to malabsorption and intestinal failure-associated liver disease. Intestinal adaptation (IA) driven by sustained enteral nutrition (EN) is essential, but EN delivery is limited after major resection. We developed DREAM (Distal Recirculation of Enteral contents Augmented Mechanically), which enables complete EN despite SBS, and enhances IA. We evaluated its efficacy in a translational large-animal model.
233. IBDome: An Integrated Molecular, Histopathological, and Clinical Atlas of Inflammatory Bowel Diseases.
作者: Christina Plattner.;Gregor Sturm.;Anja A Kühl.;Raja Atreya.;Sandro Carollo.;Dietmar Rieder.;Raphael Gronauer.;Michael Günther.;Steffen Ormanns.;Claudia Manzl.;Stefan Wirtz.;Asier Rabasco Meneghetti.;Ahmed N Hegazy.;Jay V Patankar.;Zunamys I Carrero.;Felix Grabherr.;Moritz Meyer.; .;Timon E Adolph.;Herbert Tilg.;Markus F Neurath.;Jakob Nikolas Kather.;Christoph Becker.;Britta Siegmund.;Zlatko Trajanoski.
来源: Gastroenterology. 2026年
Multiomic and multimodal datasets with detailed clinical annotations offer significant potential to advance understanding of inflammatory bowel diseases (IBDs), refine diagnostics, and enable personalized therapeutic strategies.
235. The impact of early enteral nutrition on length of hospital stay in adult severe acute pancreatitis: a retrospective cohort study.
To investigate the impact of early enteral nutrition on hospital stay in adults with severe acute pancreatitis (SAP).
236. Validation of the C-WATCH score for predicting severity in patients with upper gastrointestinal bleeding at a tertiary public hospital in Lima, Peru.
作者: Jorge Espinoza-Ríos.;Renatto Ruiz-Cortez.;Brendy Santiago.;Jorge Huerta-Mercado Tenorio.
来源: BMC Gastroenterol. 2026年26卷1期
Upper gastrointestinal bleeding (UGIB) remains one of the most common emergencies in gastroenterology, with mortality rates reaching 14% in some settings. Despite advances in management, mortality has remained relatively unchanged. Several risk stratification tools, including Glasgow-Blatchford, AIMS65, and Rockall scores, are used to predict adverse outcomes. More recently, the C-WATCH score has been proposed as a simplified alternative. We aimed to validate the ability of the C-WATCH score to predict severity in patients with UGIB in a tertiary public hospital in Lima, Peru.
237. Impact of Availability of Computer-Aided Detection Devices on Adenoma Detection During Colonoscopy: A Cluster Randomized Study.
作者: Jason A Dominitz.;Andrew J Gawron.;Grace B McKee.;Katherine J Hoggatt.;Tonya Kaltenbach.
来源: Gastroenterology. 2026年
Endoscopists' colonoscopy adenoma detection rates (ADRs) are inversely associated with their patients' risk of postcolonoscopy colorectal cancer death. Although randomized controlled trials have found that computer-aided detection (CADe) devices significantly improve ADRs, real-world studies have generally failed to demonstrate a benefit.
238. A Subphenotype of Obesity With Reduced Enteroendocrine Glucagon-Like Peptide 1 Synthesis and Enhanced Tirzepatide Response.
作者: Alexander L Ticho.;Alison N McRae.;Lizeth Cifuentes.;Thomas Fredrick.;Diego Anazco.;Maria A Espinosa.;Juan M Garcia Cordova.;Michael Romanos.;Jose Villamarin.;Stephen Johnson.;Ryan Lennon.;Maria D Hurtado Andrade.;Jun Chen.;Michael Camilleri.;Andres J Acosta.
来源: Gastroenterology. 2026年
Obesity is a heterogeneous disease characterized by different pathophysiological and behavioral traits that influence response to glucagon-like peptide 1 (GLP-1)-based therapies. We previously identified an obesity phenotype characterized by fast gastric emptying (GE) and increased postprandial hunger. We aimed to elucidate pathophysiological mechanisms in this phenotype by evaluating plasma enteroendocrine hormones and mucosal gene expression and to evaluate treatment response to tirzepatide across subphenotypes.
239. PRDM9 Deficiency Drives Mosaic Promoter Deletions in Sporadic Hirschsprung Disease and Supports Blood-Based Molecular Stratification.
作者: Yun Zhu.;Xiaoyu Zuo.;Kai Song.;Yongxuan Yao.;Lihua Huang.;Qiuming He.;Zipeng Liu.;Yi Zheng.;Xiaoli Xie.;Xinying Zhao.;Ye He.;Weiyong Zhong.;Tuqun Hu.;Zhihai Liu.;Jiazhang Chen.;Shenwei Huang.;Xingqiang Lai.;Xiaogang Xu.;Wei Zhong.;Jixiao Zeng.;Wenhao Zhou.;Huimin Xia.;Yan Zhang.
来源: Gastroenterology. 2026年
Hirschsprung disease (HSCR) is a congenital enteric neuropathy with distal aganglionosis and dysmotility. Germline mutations explain many familial cases, but most sporadic cases lack a molecular explanation. We sought noncanonical mechanisms and blood-accessible biomarkers.
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