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2074. [177Lu]Lu-DOTA-TATE plus long-acting octreotide versus high‑dose long-acting octreotide for the treatment of newly diagnosed, advanced grade 2-3, well-differentiated, gastroenteropancreatic neuroendocrine tumours (NETTER-2): an open-label, randomised, phase 3 study.
作者: Simron Singh.;Daniel Halperin.;Sten Myrehaug.;Ken Herrmann.;Marianne Pavel.;Pamela L Kunz.;Beth Chasen.;Salvatore Tafuto.;Secondo Lastoria.;Jaume Capdevila.;Amparo García-Burillo.;Do-Youn Oh.;Changhoon Yoo.;Thorvardur R Halfdanarson.;Stephen Falk.;Ilya Folitar.;Yufen Zhang.;Paola Aimone.;Wouter W de Herder.;Diego Ferone.; .
来源: Lancet. 2024年403卷10446期2807-2817页
There are currently no standard first-line treatment options for patients with higher grade 2-3, well-differentiated, advanced, gastroenteropancreatic neuroendocrine tumours. We aimed to investigate the efficacy and safety of first-line [177Lu]Lu-DOTA-TATE (177Lu-Dotatate) treatment.
2077. Early versus delayed weight-bearing following operatively treated ankle fracture (WAX): a non-inferiority, multicentre, randomised controlled trial.
作者: Christopher Patrick Bretherton.;Juul Achten.;Vidoushee Jogarah.;Stavros Petrou.;Nicholas Peckham.;Felix Achana.;Duncan Appelbe.;Rebecca Kearney.;Harry Claireux.;Philip Bell.;Xavier L Griffin.; .
来源: Lancet. 2024年403卷10446期2787-2797页
After surgery for a broken ankle, patients are usually instructed to avoid walking for 6 weeks (delayed weight-bearing). Walking 2 weeks after surgery (early weight-bearing) might be a safe and preferable rehabilitation strategy. This study aimed to determine the clinical and cost effectiveness of an early weight-bearing strategy compared with a delayed weight-bearing strategy.
2078. Vimseltinib versus placebo for tenosynovial giant cell tumour (MOTION): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial.
作者: Hans Gelderblom.;Vivek Bhadri.;Silvia Stacchiotti.;Sebastian Bauer.;Andrew J Wagner.;Michiel van de Sande.;Nicholas M Bernthal.;Antonio López Pousa.;Albiruni Abdul Razak.;Antoine Italiano.;Mahbubl Ahmed.;Axel Le Cesne.;Gabriel Tinoco.;Kjetil Boye.;Javier Martín-Broto.;Emanuela Palmerini.;Salvatore Tafuto.;Sarah Pratap.;Benjamin C Powers.;Peter Reichardt.;Antonio Casado Herráez.;Piotr Rutkowski.;Christopher Tait.;Fiona Zarins.;Brooke Harrow.;Maitreyi G Sharma.;Rodrigo Ruiz-Soto.;Matthew L Sherman.;Jean-Yves Blay.;William D Tap.; .
来源: Lancet. 2024年403卷10445期2709-2719页
Tenosynovial giant cell tumour (TGCT) is a locally aggressive neoplasm for which few systemic treatment options exist. This study evaluated the efficacy and safety of vimseltinib, an oral, switch-control, CSF1R inhibitor, in patients with symptomatic TGCT not amenable to surgery.
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