15. Celiac Disease.
Celiac disease, a common autoimmune condition affecting approximately 1% of the population, can develop with exposure to gluten at any age. Diagnosis involves serologic testing, especially for IgA antibodies against tissue transglutaminase, and may include tests to confirm the presence of endomysial antibodies or even duodenal biopsies, although the latter are becoming less necessary. The presence of genes encoding HLA-DQ2 or HLA-DQ8 is a prerequisite for the disease. A gluten-free diet is the mainstay of treatment, but some adults have nonresponsive celiac disease, which warrants closer monitoring because of an increased risk of malignant conditions. Celiac disease also frequently co-occurs with other autoimmune disorders, such as type 1 diabetes mellitus and autoimmune thyroid disease.
16. Immunogenicity and Safety of vYF, a Yellow Fever Vaccine - A Phase 2 Trial.
作者: Emmanuel Feroldi.;Mark J Mulligan.;Kawsar R Talaat.;Chen Sabrina Tan.;Kristopher Paolino.;Srilatha Edupuganti.;Matthew H Collins.;Sarah L George.;Matthew Davis.;Brandon Essink.;Robert Jeanfreau.;James Peterson.;David Fried.;Ada-Maria Minutello.;Sandrine Orlando.;Joanna Korejwo.;Andrey Rojas.;Marine Dufournet.;Tifany Machabert.;Louis Devlin.;Carina Frago.; .
来源: N Engl J Med. 2026年394卷14期1399-1408页
A next-generation, live-attenuated yellow fever vaccine, vYF, was developed in Vero cells to improve vaccine supply and availability. The safety of and immune response to vYF as compared with those of the licensed yellow fever vaccine, YF-VAX, are unclear.
17. A Phase 2 Randomized Trial of Mezagitamab in Primary Immune Thrombocytopenia.
作者: David J Kuter.;Katsuhiro Miura.;Andrea Patriarca.;Dražen Pulanić.;Atanas Radinoff.;Katya Sapunarova.;Antonia Syrigou.;Renchi Yang.;Van Anh Nguyen.;Emily Skelton.;Scarlett Wang.;Donald L Yee.;Parth Patwari.; .
来源: N Engl J Med. 2026年394卷14期1388-1398页
Immune thrombocytopenia (ITP) is a disorder of increased platelet destruction and reduced platelet production and is associated with an increased bleeding risk and a compromised quality of life. Available therapies are ineffective in at least 20% of cases. Mezagitamab is an anti-CD38 antibody that targets plasma cells, plasmablasts, and natural killer cells.
18. Multifaceted Strategies for Hypertension Control in Low-Income Patients.
作者: Katherine T Mills.;Marie Krousel-Wood.;Erin M Peacock.;Jing Chen.;Farah Allouch.;Amy K Carreras.;Siyi Geng.;Alecia Cyprian.;Gerrelda Davis.;Sonja R Fuqua.;Darie Gilliam.;Angelique Greer.;Tammy Mitchell.;Wylea Gray-Winfrey.;Shondra Williams.;Gary M Wiltz.;Keith L Winfrey.;Hua He.;Paul K Whelton.;Jiang He.
来源: N Engl J Med. 2026年394卷14期1376-1387页
Uncontrolled hypertension disproportionately affects populations that have substantial health disparities. Data regarding the effectiveness and implementation of multifaceted, team-based strategies for hypertension control among low-income patients are lacking.
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